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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK PIM1 203
Other CAMKK2 165
CMGC CDK2 4
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CAMK DAPK1 13
CAMK NUAK1 55
CAMK PIM2 132
CAMK PIM3 40
YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRV---------------------PMEVVLLKKV-S----SGFSGVIRLLDWFER--PDSFVLILER-PEPVQDLFDFIT--ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL----KLIDFGSGA--LLKDTVYTDFDGTRVYSPPEWIRYHRY--HGRSAAVWSLGILLYDMVCGDIPFE-HD---------EEIIRGQVFFRQRVS----------------------------------SECQHLIRWCLALRPSDRPTFEEIQNHPWM-
YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL-D----HPN--VVKLVEVLDDPNEDHLYMVFEL-VNQG-PVMEVPT---LKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG-EDGHI----KIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFM-DE---RIMCLHSKIKSQALEFPDQPDIA--------------------------------EDLKDLITRMLDKNPESRIVVPEIKLHPWV-
FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR-------------------------EISLLKEL-N----HPN--IVKLLDVIHT--ENKLYLVFEF-LHQ--DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY--YSTAVDIWSLGCIFAEMVTRRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-
YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR------------------------------EIKILENLRG----GPN--IITLADIVKDPVSRTPALVFEH-VNNT-DFKQLY-----QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF-YHPGQEYNVRVASRYFKGPELLVDYQM--YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF-
YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKR------------------------------EVKILENLRG----GTN--IIKLIDTVKDPVSKTPALVFEY-INNT-DFKQLY-----QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKL----RLIDWGLAEF-YHPAQEYNVRVASRYFKGPELLVDYQM--YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF-
YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDI---------------------EREVSILKEI-Q----HPN--VITLHEVYEN--KTDVILILEL-VAGG-ELFDFLA--EKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK-IDFGNEFKNIFGTPEFVAPEIVN-YEP--LGLEADMWSIGVITYILLSGASPFL-GD---TKQETLANVSAVNYEFEDEYFSNTS------------------------------ALAKDFIRRLLVKDPKKRMTIQDSLQHPWI-
YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIR------------------------REIEIMSSL-N----HPH--IISIYEVFEN--KDKIVIIMEY-ASKG-ELYDYIS--ERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLD-DNCNI----KIADFGLSNL-YQKDKFLQTFCGSPLYASPEIVNGRPY--RGPEVDSWALGVLLYTLVYGTMPFD-GF---DHKNLIRQISSGEYREPTQP-----------------------------------SDARGLIRWMLMVNPDRRATIEDIANHWW-V
YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTC---------------------PLEVALLWKV-GAGGGHPG--VIRLLDWFET--QEGFMLVLERPLPAQ-DLFDYIT--EKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCA----KLIDFGSGA--LLHDEPYTDFDGTRVYSPPEWISRHQY--HALPATVWSLGILLYDMVCGDIPFE-RD---------QEILEAELHFPAHVS----------------------------------PDCCALIRRCLAPKPSSRPSLEEILLDPWM-
YQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATV----------------------PLEVVLLRKV-GAAGGARG--VIRLLDWFER--PDGFLLVLER-PEPAQDLFDFIT--ERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGEL----KLIDFGSGA--LLKDTVYTDFDGTRVYSPPEWIRYHRY--HGRSATVWSLGVLLYDMVCGDIPFE-QD---------EEILRGRLLFRRRVS----------------------------------PECQQLIRWCLSLRPSERPSLDQIAAHPWM-
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