|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK PIM3 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDK9 2.7.11.23
CAMK CHEK1 9
Other EIF2AK2 267
TK FYN 271
CMGC GSK3B 56
TK NTRK3 538
STE PAK4 321
AGC RPS6KA2 59
----YQVGAVLGSGGFGTVYAGSRI-----ADGL---PVAVKHVVKERVTEWG-SLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFER-----------------------------PDGFL--LVLERPEPA-QDLFDFIT----ERG-----------------ALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGA-------LLKDTVY--------------TD---FDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC-GD-IPFEQD---------EEILRGRLLFRRRVS-----------------------------PECQQLIRWCLSLRPSERPS-----LDQIAAHPWM---
----YTKIEKIGEGTYGVVYKGRHK-----TTGQ---VVAMKKIRLESEEEGV-PSTAIR---EISLLKELR----HPNIVSLQDVLMQ-----------------------------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF-----GIPIRVY--------------TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KK-PLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF---
----FQKVEKIGEGTYGVVYKARNK-----LTGE---VVALKKIRLDTETEGV-PSTAIR---EISLLKELN----HPNIVKLLDVIHT-----------------------------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF-----GVPVRTY--------------TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RR-ALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF---
----FQKVEKIGEGTYGVVYKAKNR-----ETGQ---LVALKKIRLDLEMEGV-PSTAIR---EISLLKELK----HPNIVRLLDVVHN-----------------------------ERKLY--LVFEFLSQ---DLKKYMDS--TPGS-----------------ELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLIN-ELGAIKLADFGLARAF-----GVPLRTY--------------TH---EVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVT-RK-ALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR---KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT-----AKTALAHPYF---
----YEKLEKIGEGTYGTVFKAKNR-----ETHE---IVALKRVRLDDDDEGV-PSSALR---EICLLKELK----HKNIVRLHDVLHS-----------------------------DKKLT--LVFEFCDQ---DLKKYFD---SCNG-----------------DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAF-----GIPVRCY--------------SA---EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGR-PLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT---TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF---
----YEKLAKIGQGTFGEVFKARHR-----KTGQ---KVALKKVLMENEKEGF-PITALR---EIKILQLLK----HENVVNLIEICRTKASP---------------------YNRCKGSIY--LVFDFCEH---DLAGLLS---NVLV-----------------KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVLKLADFGLARAFSL-AKNSQPNRY--------------TN---RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RS-PIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF---
---W-DLVQTLGEGAYGEVQLAVNR-----VTEE---AVAVKIVDMKRAVDCP-ENI-KK---EICINKMLN----HENVVKFYGHRRE-----------------------------GNIQY--LFLEYCSGG--ELFDRIE----PDI-----------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNLKISDFGLATVFR---YNNRERLL--------------NK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GE-LPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D-------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y--
---F-KEIELIGSGGFGQVFKAKHR-----IDGK---TYVIKRVKYNNEKAER----------EVKALAKLD----HVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK--RRGE-----------------KLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLV-DTKQVKIGDFGLVTS------LKNDGKR--------------TR---SKGTLRYMSPEQIS-SQDYGKEVDLYALGLILAELLH-VCDTAFET-------SKFFTDLRDGIISDIFDK------------------------------KEKTLLQKLLSKKPEDRPN-----TSEILR----TLT
----LQLIKRLGNGQFGEVWMGTWN------GNT---KVAIKTLK-PGTM-SP-ESFL-E---EAQIMKKLK----HDKLVQLYAVVS------------------------------EEPIY--IVTEYMNKG--SLLDFLK-----DG--------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVG-NGLICKIADFGLARLI-----E--DNEY--------------TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGR-VPYPGMNNREVLEQVERGYRMPCPQDCP-------------------------------ISLHELMIHCWKKDPEERPT-----FEYLQSFL-----
----YTDTKVIGNGSFGVVYQAKLC-----DSGE---LVAIKKVLQDKRFKNR----------ELQIMRKLD----HCNIVRLRYFFYSSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ------LVRGEPN--------------VS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQ-PIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF---
---I-VLKRELGEGAFGKVFLAECYNLSPTKDKM---LVAVKALK-DPTL-AARKDFQ-R---EAELLTNLQ----HEHIVKFYGVCGD-----------------------------GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVG-ANLLVKIGDFGMSRDV--Y--S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGK-QPWFQLSNTEVIECITQGRVLERPRVCP-------------------------------KEVYDVMLGCWQREPQQRLN-----IKEIYKIL-----
DNFI-----KIGEGSTGIVCIATVR-----SSGK---LVAVKKMDLRKQQRRE-L--LFN---EVVIMRDYQ----HENVVEMYNSYLV-----------------------------GDELW--VVMEFLEGG--ALTDIVT-----HT-----------------RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLT-HDGRVKLSDFGFCAQV-----SKEVPRR--------------KS---LVGTPYWMAPELIS-RLPYGPEVDIWSLGIMVIEMVD-GE-PPYFNEPPLKAMKMIRDNLPPRLKNLHKVS-----------------------------PSLKGFLDRLLVRDPAQRAT-----AAELLKHPFL---
----FELLKVLGQGSYGKVFLVRKV-----KGSDAGQLYAMKVLKKATLKVRD-RVRSKM---ERDILAEVN----HPFIVKLHYAFQT-----------------------------EGKLY--LILDFLRGG--DLFTRLS----KEV-----------------MFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD-EEGHIKITDFGLSKEA-----IDHDKRA--------------YS---FCGTIEYMAPEVVN-RRGHTQSADWWSFGVLMFEMLT-GS-LPFQGK---DRKETMALILKAKLGMPQFLS-----------------------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF---
|