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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PKN1 203
TK ABL1 261
TK ABL2 288
TKL ACVR1 208
TK ALK 1116
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK BLK 241
TKL BMPR1B 204
TK BMX 422
CAMK BRSK1 50
TK BTK 402
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
CMGC CDKL2 4
CMGC CDKL3 4
CMGC CDKL5 13
TK CSF1R 582
TK CSK 195
CAMK DAPK3 13
TK EPHA1 624
TK EPHA3 621
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB4 615
TK EPHB6 670
TK ERBB3 709
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FRK 234
TK FYN 271
TK HCK 241
CAMK HUNK 61
TKL IRAK4 186
TK ITK 363
TK JAK2 849
TK JAK3 822
TK KIT 589
TK LCK 245
TKL LIMK1 339
TKL LIMK2 331
TK LTK 510
TK LYN 247
CMGC MAPK14 24
CAMK MARK2 53
CAMK MARK4 59
CAMK MELK 11
Other NEK5 4
CAMK NUAK1 55
CAMK NUAK2 97
TK PDGFRA 593
TK PDGFRB 600
AGC PKN2 657
CAMK PRKAA1 18
CAMK PRKAA2 16
AGC PRKCD 349
AGC PRKCQ 380
TK RET 724
TKL RIPK1 17
TK ROS1 1945
CAMK SIK1 27
CAMK SIK2 20
TK SRC 270
STE STK24 24
TK SYK 371
TK TEC 370
TK TEK 824
TKL TGFBR1 205
TK TIE1 839
TK TNK1 116
TK TNK2 150
TK TXK 271
TK YES1 277
--F-KFLAVLGRGHFGKVLLSEFR-------PSGELFAI-KAL---KKG--D-IVARD---E-VESLM---CEKRILAAV--TSAGHPFLVNLFGCFQ--T------PEHVCFVMEYSAGGDLMLHIH----SD----------------------------------------------------------------------------------------------------VFSEPRAIFYSACVVLGLQFLHEH--------KIVYRDLKLDNLLLDT-----EGYV----KIADFGLCKEG----------------MGYGDRT------------ST---FCGTPEFLAPEVLT------DTS--YTRAVDWWGLGVLLYEMLV-GE--------------SP---------------FPGD--------DEEEVF-DSIVNDE---VRYPRFLS-----------------------------AEAIG-IMRRLLRRNPERRLGSSERDAE-DVKKQPFF---
---ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAV-KTL---K-E--D-TM-EV---E-EFL-K----EAAVMKEI--K---HPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR----EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGE-----NHLV----KVADFGLSRLM----------------T--GDTY------------TAHAGAKFPIKWTAPESLA------YNK--FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYELL-EKDYRME---RPEGCP-------------------------------EKVYE-LMRACWQWNPSDRPS-----FA-EIHQA--F---
---ITMKHKLGGGQYGEVYVGVWK-------KYSLTVAV-KTL---K-E--D-TM-EV---E-EFL-K----EAAVMKEI--K---HPNLVQLLGVCT--L------EPPFYIVTEYMPYGNLLDYLR----EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGE-----NHVV----KVADFGLSRLM----------------T--GDTY------------TAHAGAKFPIKWTAPESLA------YNT--FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYDLL-EKGYRME---QPEGCP-------------------------------PKVYE-LMRACWKWSPADRPS-----FA-ETHQA--F---
--I-TLLECVGKGRYGEVWRGSWQ-------GEN--VAV-KIF---SSR--D-EKSWF---R-ET-------ELYNTVML--R---HENILGFIASDM--TSR--HSSTQLWLITHYHEMGSLYDYLQ----LT----------------------------------------------------------------------------------------------------TLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKK-----NGQC----CIADLGLAVMHSQ------------STNQLDVGN------------NP---RVGTKRYMAPEVLDETIQVDCFD--SYKRVDIWAFGLVLWEVAR-RMVSNGI----VEDYKPP---------------FYDVVPNDPSFEDMRKVV-CVDQQRP---NIPNRWFSDPTL-------------------------TSLAK-LMKECWYQNPSARLT-----AL-RIKK----TL-
--I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAV-KTL---P-E--V-CS-EQD-EL-DFL-M----EALIISKF--N---HQNIVRCIGVSL--Q------SLPRFILLELMAGGDLKSFLR----ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN--------HFIHRDIAARNCLLTCP--GPGRVA----KIGDFGMARDI-------------Y--R--ASYY------------RKGGCAMLPVKWMPPEAFM------EGI--FTSKTDTWSFGVLLWEIFSLGY--------------MP---------------YPSK-----SNQEVLEFV-TSGGRMD---PPKNCP-------------------------------GPVYR-IMTQCWQHQPEDRPN-----FA-IILER--I---
---FEIGRPLGKGKFGNVYLAREK-------QSKFILAL-KVL---FKA--QLEKAGV---E-HQLRR----EVEIQSHL--R---HPNILRLYGYFH--D------ATRVYLILEYAPLGTVYRELQ---KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK--------RVIHRDIKPENLLLGS-----AGEL----KIADFGWSV------------------HAPSSRR------------TT---LCGTLDYLPPEMIE------GRM--HDEKVDLWSLGVLCYEFLV-GK--------------PP---------------FEAN--------TYQETY-KRISRVE---FTFPDFVT-----------------------------EGARD-LISRLLKHNPSQRPM-----LR-EVLEHPWI---
---FEIGRPLGKGKFGNVYLAREK-------KSHFIVAL-KVL---FKS--Q-IEKEG---V-EHQLR---REIEIQAHL--H---HPNILRLYNYFY--D------RRRIYLILEYAPRGELYKELQ---KSC----------------------------------------------------------------------------------------------------TFDEQRTATIMEELADALMYCHGK--------KVIHRDIKPENLLLGL-----KGEL----KIADFGWSV------------------HAPSLRR------------KT---MCGTLDYLPPEMIE------GRM--HNEKVDLWCIGVLCYELLV-GN--------------PP---------------FESA--------SHNETY-RRIVKVD---LKFPASVP-----------------------------MGAQD-LISKLLRHNPSERLP-----LA-QVSAHPWV---
---FEIGRPLGKGKFGNVYLARLK-------ESHFIVAL-KVL---FKS--Q-IEKEG---L-EHQLR---REIEIQAHL--Q---HPNILRLYNYFH--D------ARRVYLILEYAPRGELYKELQ---KSE----------------------------------------------------------------------------------------------------KLDEQRTATIIEELADALTYCHDK--------KVIHRDIKPENLLLGF-----RGEV----KIADFGWSV------------------HTPSLRR------------KT---MCGTLDYLPPEMIE------GRT--YDEKVDLWCIGVLCYELLV-GY--------------PP---------------FESA--------SHSETY-RRILKVD---VRFPLSMP-----------------------------LGARD-LISRLLRYQPLERLP-----LA-QILKHPWV---
--L-RLVRKLGSGQFGEVWMGYYK--------NNMKVAI-KTL---K-E--G-TM-SP---E-AFL-G----EANVMKAL--Q---HERLVRLYAVVT---------KEPIYIVTEYMARGCLLDFLK----TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERM--------NSIHRDLRAANILVSE-----ALCC----KIADFGLARII-------------------DSEY------------TAQEGAKFPIKWTAPEAIH------FGV--FTIKADVWSFGVLLMEVVTYGR--------------VP---------------YPGM-----SNPEVIRNL-ERGYRMP---RPDTCP-------------------------------PELYRGVIAECWRSRPEERPT-----FE-FLQSV--L---
--I-QMVKQIGKGRYGEVWMGKWR-------GEK--VAV-KVF---FTT--E-EASWF---R-ET-------EIYQTVLM--R---HENILGFIAADI--KGT--GSWTQLYLITDYHENGSLYDYLK----ST----------------------------------------------------------------------------------------------------TLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKK-----NGTC----CIADLGLAVKFIS------------DTNEVDIPP------------NT---RVGTKRYMPPEVLDESLNRNHFQ--SYIMADMYSFGLILWEVAR-RCVSGGIVEEYQLPYHD-------------------LVPSDPSYEDMREIV-CIKKLRP---SFPNRWSSDECL-------------------------RQMGK-LMTECWAHNPASRLT-----AL-RVKK----TL-
---ITLLKELGSGQFGVVQLGKWK--------GQYDVAV-KMI---K-E--G-SM-SE---D-EFF-Q----EAQTMMKL--S---HPKLVKFYGVCS--K------EYPIYIVTEYISNGCLLNYLR----SH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESH--------QFIHRDLAARNCLVDR-----DLCV----KVSDFGMTRYV----------------L--DDQY------------VSSVGTKFPVKWSAPEVFH------YFK--YSSKSDVWAFGILMWEVFSLGK--------------QP---------------YDLY-----DNSQVVLKV-SQGHRLY---RPHLAS-------------------------------DTIYQ-IMYSCWHELPEKRPT-----FQ-QLLSS--I---
---YRLEKTLGKGQTGLVKLGVHC-------ITGQKVAI-KIV---NRE--K-LSESV---L-MKVER----EIAILKLI--E---HPHVLKLHDVYE--N------KKYLYLVLEHVSGGELFDYLV---KKG----------------------------------------------------------------------------------------------------RLTPKEARKFFRQIVSALDFCHSY--------SICHRDLKPENLLLDE-----KNNI----RIADFGMASL-----------------QVGDSLL------------ET---SCGSPHYACPEVIK-----GEKY--DGRRADMWSCGVILFALLV-GA--------------LP---------------FDDD--------NLRQLL-EKVKRGV---FHMPHFIP-----------------------------PDCQS-LLRGMIEVEPEKRLS-----LE-QIQKHPW-Y--
---LTFLKELGTGQFGVVKYGKWR--------GQYDVAI-KMI---K-E--G-SM-SE---D-EFI-E----EAKVMMNL--S---HEKLVQLYGVCT--K------QRPIFIITEYMANGCLLNYLR----EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESK--------QFLHRDLAARNCLVND-----QGVV----KVSDFGLSRYV----------------L--DDEY------------TSSVGSKFPVRWSPPEVLM------YSK--FSSKSDIWAFGVLMWEIYSLGK--------------MP---------------YERF-----TNSETAEHI-AQGLRLY---RPHLAS-------------------------------EKVYT-IMYSCWHEKADERPT-----FK-ILLSN--I---
---YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAM-KKI---RLE--S-EEEGV---P-STAIR----EISLLKEL--R---HPNIVSLQDVLM--Q------DSRLYLIFEFLSM-DLKKYLDSIPPGQ----------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSR--------RVLHRDLKPQNLLIDD-----KGTI----KLADFGLARAF----------------GIPIRVY------------TH---EVVTLWYRSPEVLL-----GSAR--YSTPVDIWSIGTIFAELAT-KK--------------PL---------------FHGD-----SEIDQLFRI-FRALGTP---NNEVWPEVESLQDYKNTFPKWKP---GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-----GK-MALNHPYF---
---FQKVEKIGEGTYGVVYKARNK-------LTGEVVAL-KKI---RLD--T-ETEGV---P-STAIR----EISLLKEL--N---HPNIVKLLDVIH--T------ENKLYLVFEFLHQ-DLKKFMDA-SALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH--------RVLHRDLKPQNLLINT-----EGAI----KLADFGLARAF----------------GVPVRTY------------TH---EVVTLWYRAPEILL-----GCKY--YSTAVDIWSLGCIFAEMVT-RR--------------AL---------------FPGD-----SEIDQLFRI-FRTLGTP---DEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-----AK-AALAHPFF---
---YEKLEKIGEGTYGTVFKAKNR-------ETHEIVAL-KRV---RLD--D-DDEGV---P-SSALR----EICLLKEL--K---HKNIVRLHDVLH--S------DKKLTLVFEFCDQ-DLKKYFD--SCNG----------------------------------------------------------------------------------------------------DLDPEIVKSFLFQLLKGLGFCHSR--------NVLHRDLKPQNLLINR-----NGEL----KLADFGLARAF----------------GIPVRCY------------SA---EVVTLWYRPPDVLF-----GAKL--YSTSIDMWSAGCIFAELANAGR--------------PL---------------FPGN-----DVDDQLKRI-FRLLGTP---TEEQWPSMTKLPDYKPYPMYPAT---TSLVNVVPKLNATGRD-LLQNLLKCNPVQRIS-----AE-EALQHPYF---
---YENLGLVGEGSYGMVMKCRNK-------DTGRIVAI-KKF---LES--D-DDKMV---K-KIAMR----EIKLLKQL--R---HENLVNLLEVCK--K------KKRWYLVFEFVDHTILDDLEL---FPN----------------------------------------------------------------------------------------------------GLDYQVVQKYLFQIINGIGFCHSH--------NIIHRDIKPENILVSQ-----SGVV----KLCDFGFARTL----------------AAPGEVY------------TD---YVATRWYRAPELLV-----GDVK--YGKAVDVWAIGCLVTEMFM-GE--------------PL---------------FPGD-----SDIDQLYHI-MMCLGNL---IPRHQELFNKNPVFAGVRLPEIKE-REPLERRYPKLSEVVID-LAKKCLHIDPDKRPF-----CA-ELLHHDFF---
---YETLGKVGEGSYGTVMKCKHK-------NTGQIVAI-KIF---YER--P-EQSVN---K--IAMR----EIKFLKQF--H---HENLVNLIEVFR--Q------KKKIHLVFEFIDHTVLDELQH---YCH----------------------------------------------------------------------------------------------------GLESKRLRKYLFQILRAIDYLHSN--------NIIHRDIKPENILVSQ-----SGIT----KLCDFGFARTL----------------AAPGDIY------------TD---YVATRWYRAPELVL-----KDTS--YGKPVDIWALGCMIIEMAT-GN--------------PY---------------LPSS-----SDLDLLHKI-VLKVGN----LSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLAD-IVHACLQIDPADRIS-----SS-DLLHHEYF---
---FEILGVVGEGAYGVVLKCRHK-------ETHEIVAI-KKF---KDS--E-ENEEV---K-ETTLR----ELKMLRTL--K---QENIVELKEAFR--R------RGKLYLVFEYVEK-NMLELLE--EMPN----------------------------------------------------------------------------------------------------GVPPEKVKSYIYQLIKAIHWCHKN--------DIVHRDIKPENLLISH-----NDVL----KLCDFGFARNL---------------SEGNNANY------------TE---YVATRWYRSPELLL------GAP--YGKSVDMWSVGCILGELSD-GQ--------------PL---------------FPGE-----SEIDQLFTI-QKVLGPL---PSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLD-LMKNLLKLDPADRYL-----TE-QCLNHPTF---
---LQFGKTLGAGAFGKVVEATAFG--LGKEDAVLKVAV-KML---K-S--T-AH-ADE-KE-ALM-S----ELKIMSHLG-Q---HENIVNLLGACT--H------GGPVLVITEYCCYGDLLNFLR----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASK--------NCIHRDVAARNVLLTN-----GHVA----KIGDFGLARDI-------------M--N--DSNY------------IVKGNARLPVKWMAPESIF------DCV--YTVQSDVWSYGILLWEIFSLGL--------------NP---------------YPGI-L---VNSKFYKLV-KDGYQMA---QPAFAP-------------------------------KNIYS-IMQACWALEPTHRPT-----FQ-QICSFL-----
---LKLLQTIGKGEFGDVMLGDYR---------GNKVAV-KCI---K-N--D-AT-AQ-----AFL-A----EASVMTQL--R---HSNLVQLLGVIV-EE------KGGLYIVTEYMAKGSLVDYLR----SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGN--------NFVHRDLAARNVLVSE-----DNVA----KVSDFGLTKEA----------------------S------------STQDTGKLPVKWTAPEALR------EKK--FSTKSDVWSFGILLWEIYSFGR--------------VP---------------YPRI-----PLKDVVPRV-EKGYKMD---APDGCP-------------------------------PAVYE-VMKNCWHLDAAMRPS-----FL-QLREQL-----
---YEMGEELGSGQFAIVRKCRQK-------GTGKEYAA-KFI---KKR--R-LSSSR---R-GVSREEIEREVNILREI--R---HPNIITLHDIFE--N------KTDVVLILELVSGGELFDFLA---EKE----------------------------------------------------------------------------------------------------SLTEDEATQFLKQILDGVHYLHSK--------RIAHFDLKPENIMLLD-----KNVPNPRIKLIDFGIAHK-----------------IEAGNEF------------KN---IFGTPEFVAPEIVN------YEP--LGLEADMWSIGVITYILLS-GA--------------SP---------------FLGE--------TKQETL-TNISAVN---YDFDEEYFSNTS-------------------------ELAKD-FIRRLLVKDPKRRMT-----IA-QSLEHSWI---
-LM--VDTVIGEGEFGEVYRGTLR----LPSQDCKTVAI-KTL---K-D--T-SP-GGQ-WW-NFL-R----EATIMGQF--S---HPHILHLEGVVT--K------RKPIMIITEFMENGALDAFLR----ER--------------------------------------------------------------------------------------------------EDQLVPGQLVAMLQGIASGMNYLSNH--------NYVHRDLAARNILVNQ-----NLCC----KVSDFGLTRLL-------------D--D--FDGT------------YETQGGKIPIRWTAPEAIA------HRI--FTTASDVWSFGIVMWEVLSFGD--------------KP---------------YGEM-----SNQEVMKSI-EDGYRLP---PPVDCP-------------------------------APLYE-LMKNCWAYDRARRPH-----FQ-KLQAHL-----
--I-SIDKVVGAGEFGEVCSGRLK----LPSKKEISVAI-KTL---K-V--G-YT-EKQ-RR-DFL-G----EASIMGQF--D---HPNIIRLEGVVT--K------SKPVMIVTEYMENGSLDSFLR----KH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDM--------GYVHRDLAARNILINS-----NLVC----KVSDFGLSRVL-------------E--D--DPEA-----------AYTTRGGKIPIRWTSPEAIA------YRK--FTSASDVWSYGIVLWEVMSYGE--------------RP---------------YWEM-----SNQDVIKAV-DEGYRLP---PPMDCP-------------------------------AALYQ-LMLDCWQKDRNNRPK-----FE-QIVSIL-----
---IHIEKIIGSGDSGEVCYGRLR----VPGQRDVPVAI-KAL---K-A--G-YT-ERQ-RR-DFL-S----EASIMGQF--D---HPNIIRLEGVVT--R------GRLAMIVTEYMENGSLDTFLR----TH--------------------------------------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSDL--------GYVHRDLAARNVLVDS-----NLVC----KVSDFGLSRVL-------------E--D--DPDA-----------AYTTTGGKIPIRWTAPEAIA------FRT--FSSASDVWSFGVVMWEVLAYGE--------------RP---------------YWNM-----TNRDVISSV-EEGYRLP---APMGCP-------------------------------HALHQ-LMLDCWHKDRAQRPR-----FS-QIVSVL-----
--V-KIEEVIGAGEFGEVYKGRLK----LPGKREIYVAI-KTL---K-A--G-YS-EKQ-RR-DFL-S----EASIMGQF--D---HPNIIRLEGVVT--K------SRPVMIITEFMENGALDSFLR----QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEM--------NYVHRDLAARNILVNS-----NLVC----KVSDFGLSRYLQ----------DDT--S--DPTY------------TSSLGGKIPVRWTAPEAIA------YRK--FTSASDVWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDVINAI-EQDYRLP---PPMDCP-------------------------------AALHQ-LMLDCWQKDRNSRPR-----FA-EIVNTL-----
--V-KIEQVIGAGEFGEVCSGHLK----LPGKREIFVAI-KTL---K-S--G-YT-EKQ-RR-DFL-S----EASIMGQF--D---HPNVIHLEGVVT--K------STPVMIITEFMENGSLDSFLR----QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADM--------NYVHRDLAARNILVNS-----NLVC----KVSDFGLSRFLE----------DDT--S--DPTY------------TSALGGKIPIRWTAPEAIQ------YRK--FTSASDVWSYGIVMWEVMSYGE--------------RP---------------YWDM-----TNQDVINAI-EQDYRLP---PPMDCP-------------------------------SALHQ-LMLDCWQKDRNHRPK-----FG-QIVNTL-----
--V-KIEEVIGAGEFGEVCRGRLK----APGKKESCVAI-KTL---K-G--G-YT-ERQ-RR-EFL-S----EASIMGQF--E---HPNIIRLEGVVT--N------SMPVMILTEFMENGALDSFLR----LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEM--------SYVHRDLAARNILVNS-----NLVC----KVSDFGLSRFLE----------ENS--S--DPTY------------TSSLGGKIPIRWTAPEAIA------FRK--FTSASDAWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDVINAI-EQDYRLP---PPPDCP-------------------------------TSLHQ-LMLDCWQKDRNARPR-----FP-QVVSAL-----
---IKIEEVIGTGSFGEVRQGRLQ----PRGRREQTVAI-QAL---W-A--G-GA-ESL-QM-TFL-G----RAAVLGQF--Q---HPNILRLEGVVT--K------SRPLMVLTEFMELGPLDSFLR----QR--------------------------------------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSF--------AFVHRSLSAHSVLVNS-----HLVC----KVARLGHSPQG----------------------------------------PSCLLRWAAPEVIA------HGK--HTTSSDVWSFGILMWEVMSYGE--------------RP---------------YWDM-----SEQEVLNAI-EQEFRLP---PPPGCP-------------------------------PGLHL-LMLDTWQKDRARRPH-----FD-QLVA---AF--
--L-RKLKVLGSGVFGTVHKGVWIP---EGESIKIPVCI-KVI---E-D--K-SG-RQS-FQ-AVT-D----HMLAIGSL--D---HAHIVRLLGLCP---------GSSLQLVTQYLPLGSLLDHVR----QH--------------------------------------------------------------------------------------------------RGALGPQLLLNWGVQIAKGMYYLEEH--------GMVHRNLAARNVLLKS-----PSQV----QVADFGVADLL-------------P--P--DDKQ------------LLYSEAKTPIKWMALESIH------FGK--YTHQSDVWSYGVTVWELMTFGA--------------EP---------------YAGL-----RLAEVPDLL-EKGERLA---QPQICT-------------------------------IDVYM-VMVKCWMIDENIRPT-----FK-ELANE--F---
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAV-KML---K-S--D-AT-EKD-LS-DLI-S----EMEMMKMIG-K---HKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--------KCIHRDLAARNVLVTE-----DNVM----KIADFGLARDI-------------H--H--IDYY------------KKTTNGRLPVKWMAPEALF------DRI--YTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGV-----PVEELFKLL-KEGHRMD---KPSNCT-------------------------------NELYM-MMRDCWHAVPSQRPT-----FK-QLVEDL-----
---LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAV-KML---K-D--D-AT-EKD-LS-DLV-S----EMEMMKMIG-K---HKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLR----ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ--------KCIHRDLAARNVLVTE-----NNVM----KIADFGLARDI-------------N--N--IDYY------------KKTTNGRLPVKWMAPEALF------DRV--YTHQSDVWSFGVLMWEIFTLGG--------------SP---------------YPGI-----PVEELFKLL-KEGHRMD---KPANCT-------------------------------NELYM-MMRDCWHAVPSQRPT-----FK-QLVEDL-----
---LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAV-KML---K-D--D-AT-DKD-LS-DLV-S----EMEMMKMIG-K---HKNIINLLGACT--Q------GGPLYVLVEYAAKGNLREFLR----ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQ--------KCIHRDLAARNVLVTE-----DNVM----KIADFGLARDV-------------H--N--LDYY------------KKTTNGRLPVKWMAPEALF------DRV--YTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGI-----PVEELFKLL-KEGHRMD---KPANCT-------------------------------HDLYM-IMRECWHAAPSQRPT-----FK-QLVEDL-----
--L-VLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAV-KML---K-D--N-AS-DKD-LA-DLV-S----EMEVMKLIG-R---HKNIINLLGVCT--Q------EGPLYVIVECAAKGNLREFLR----ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESR--------KCIHRDLAARNVLVTE-----DNVM----KIADFGLARGV-------------H--H--IDYY------------KKTSNGRLPVKWMAPEALF------DRV--YTHQSDVWSFGILLWEIFTLGG--------------SP---------------YPGI-----PVEELFSLL-REGHRMD---RPPHCP-------------------------------PELYG-LMRECWHAAPSQRPT-----FK-QLVEAL-----
---ITLERRLGTGCFGDVWLGTWN--------GSTKVAV-KTL---K-P--G-TM-SP---K-AFL-E----EAQVMKLL--R---HDKLVQLYAVVS---------EEPIYIVTEFMCHGSLLDFLK----NP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERM--------NYIHRDLRAANILVGE-----RLAC----KIADFGLARLI----------------K--DDEY------------NPCQGSKFPIKWTAPEAAL------FGR--FTIKSDVWSFGILLTELITKGR--------------IP---------------YPGM-----NKREVLEQV-EQGYHMP---CPPGCP-------------------------------ASLYE-AMEQTWRLDPEERPT-----FE-YLQSFL-----
---IQLLKRLGSGQFGEVWEGLWN--------NTTPVAV-KTL---K-P--G-SM-DP---N-DFL-R----EAQIMKNL--R---HPKLIQLYAVCT--L------EDPIYIITELMRHGSLQEYLQ----ND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESR--------NYIHRDLAARNVLVGE-----HNIY----KVADFGLARVFK-----------VD--N--EDIY------------ESRHEIKLPVKWTAPEAIR------SNK--FSIKSDVWSFGILLYEIITYGK--------------MP---------------YSGM-----TGAQVIQML-AQNYRLP---QPSNCP-------------------------------QQFYN-IMLECWNAEPKERPT-----FE-TLRWK--L---
---LQLIKRLGNGQFGEVWMGTWN--------GNTKVAI-KTL---K-P--G-TM-SP---E-SFL-E----EAQIMKKL--K---HDKLVQLYAVVS---------EEPIYIVTEYMNKGSLLDFLK----DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERM--------NYIHRDLRSANILVGN-----GLIC----KIADFGLARLI----------------E--DNEY------------TARQGAKFPIKWTAPEAAL------YGR--FTIKSDVWSFGILLTELVTKGR--------------VP---------------YPGM-----NNREVLEQV-ERGYRMP---CPQDCP-------------------------------ISLHE-LMIHCWKKDPEERPT-----FE-YLQSFL-----
---LKLEKKLGAGQFGEVWMATYN--------KHTKVAV-KTM---K-P--G-SM-SV---E-AFL-A----EANVMKTL--Q---HDKLVKLHAVVT---------KEPIYIITEFMAKGSLLDFLK----SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR--------NYIHRDLRAANILVSA-----SLVC----KIADFGLARVI----------------E--DNEY------------TAREGAKFPIKWTAPEAIN------FGS--FTIKSDVWSFGILLMEIVTYGR--------------IP---------------YPGM-----SNPEVIRAL-ERGYRMP---RPENCP-------------------------------EELYN-IMMRCWKNRPEERPT-----FE-YIQSV--L---
IGS----RKLGEGSFAKVREGLHV-------LTGEKVAI-KVI---DKK--R-AKKDT---Y-VTKNLR--REGQIQQMI--R---HPNITQLLDILE--T------ENSYYLVMELCPGGNLMHKIY---EKK----------------------------------------------------------------------------------------------------RLEESEARRYIRQLISAVEHLHRA--------GVVHRDLKIENLLLDE-----DNNI----KLIDFGLSNCAG--------------ILGYSDPF------------ST---QCGSPAYAAPELLA------RKK--YGPKIDVWSIGVNMYAMLT-GT--------------LP---------------FTVE------PFSLRALY-QKMVD-K---EMNPLPTQ--LS-------------------------TGAIS-FLRSLLEPDPVKRPN-----IQ-QALANRWL---
VGG----NKMGEGGFGVVYKGYVN-------NTT--VAV-KKL---AAM--V-DITTE---ELKQQFD---QEIKVMAKC--Q---HENLVELLGFSS--D------GDDLCLVYVYMPNGSLLDRLSCLDGTP----------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN--------HHIHRDIKSANILLDE-----AFTA----KISDFGLARASE--------------KFAQTVMT------------SR---IVGTTAYMAPEALR-------GE--ITPKSDIYSFGVVLLEIIT-GL--------------PA---------------VDEH-----REPQLLLDI-KEEIEDE---EKTIEDYIDKKMNDAD-----------------STSVEAMYS-VASQCLHEKKNKRPD-----IK-KVQQ----LLQ
---LTFVQEIGSGQFGLVHLGYWL--------NKDKVAI-KTI---R-E--G-AM-SE---E-DFI-E----EAEVMMKL--S---HPKLVQLYGVCL--E------QAPICLVFEFMEHGCLSDYLR----TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEA--------CVIHRDLAARNCLVGE-----NQVI----KVSDFGMTRFV----------------L--DDQY------------TSSTGTKFPVKWASPEVFS------FSR--YSSKSDVWSFGVLMWEVFSEGK--------------IP---------------YENR-----SNSEVVEDI-STGFRLY---KPRLAS-------------------------------THVYQ-IMNHCWKERPEDRPA-----FS-RLLRQL-----
---LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAV-KKL---Q-H--S-TE--EH-LR-DFE-R----EIEILKSL--Q---HDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ----KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK--------RYIHRDLATRNILVEN-----ENRV----KIGDFGLTKVL------------PQ--D--KEYY------------KVKEPGESPIFWYAPESLT------ESK--FSVASDVWSFGVVLYELFTYIE--------------KSKSPPAEFMRMIGNDKQGQM-----IVFHLIELL-KNNGRLP---RPDGCP-------------------------------DEIYM-IMTECWNNNVNQRPS-----FR-DLA----LRV-
--L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAV-KQL---Q-H--S-GP-DQ--QR-DFQ-R----EIQILKAL--H---SDFIVKYRGVSYGPG------RQSLRLVMEYLPSGCLRDFLQ----RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSR--------RCVHRDLAARNILVES-----EAHV----KIADFGLAKLL------------PL--D--KDYY------------VVREPGQSPIFWYAPESLS------DNI--FSRQSDVWSFGVVLYELFTYCD--------------KSCSPSAE--FLRMMGCERDV-P---ALCRLLELL-EEGQRLP---APPACP-------------------------------AEVHE-LMKLCWAPSPQDRPS-----FS-ALGP---QL--
---LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAV-KML---K-P--S-AH-LTE-RE-ALM-S----ELKVLSYLG-N---HMNIVNLLGACT--I------GGPTLVITEYCCYGDLLNFLR----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK--------NCIHRDLAARNILLTH-----GRIT----KICDFGLARDI-------------K--N--DSNY------------VVKGNARLPVKWMAPESIF------NCV--YTFESDVWSYGIFLWELFSLGS--------------SP---------------YPGM-P---VDSKFYKMI-KEGFRML---SPEHAP-------------------------------AEMYD-IMKTCWDADPLKRPT-----FK-QIVQL--I---
---LKLVERLGAGQFGEVWMGYYN--------GHTKVAV-KSL---K-Q--G-SM-SP---D-AFL-A----EANLMKQL--Q---HQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK----TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVSD-----TLSC----KIADFGLARLI----------------E--DNEY------------TAREGAKFPIKWTAPEAIN------YGT--FTIKSDVWSFGILLTEIVTHGR--------------IP---------------YPGM-----TNPEVIQNL-ERGYRMV---RPDNCP-------------------------------EELYQ-LMRLCWKERPEDRPT-----FD-YLRSV--L---
-LI--HGEVLGKGCFGQAIKVTHR-------ETGEVMVM-KEL---I----R-FD-EET-QR-TFL-K----EVKVMRCL--E---HPNVLKFIGVLY--K------DKRLNFITEYIKGGTLRGIIK----SM--------------------------------------------------------------------------------------------------DSQYPWSQRVSFAKDIASGMAYLHSM--------NIIHRDLNSHNCLVRE-----NKNV----VVADFGLARLM-------------V--D--EKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMIN------GRS--YDEKVDVFSFGIVLCEIIGRVN--------------AD---------------PDYL-P---RTMDFGLNV-RGFLDRY---CPPNCP-------------------------------PSFFP-ITVRCCDLDPEKRPS-----FV-KLEH---WL--
-LI--HGEVLGKGFFGQAIKVTHK--------ATGKVMVMKEL-----I--R-CD-EET-QK-TFL-T----EVKVMRSL--D---HPNVLKFIGVLY--K------DKKLNLLTEYIEGGTLKDFLR----SM---------------------------------------------------------------------------------------------------DPFPWQQKVRFAKGIASGMAYLHSM--------CIIHRDLNSHNCLIKL-----DKTV----VVADFGLSRLIVEERKRAPMEKATT--------KKRTL---RKNDRKKRYTVVGNPYWMAPEMLN------GKS--YDETVDIFSFGIVLCEIIGQVY--------------AD---------------PDCL-P---RTLDFGLNV-KLFWEKF---VPTDCP-------------------------------PAFFP-LAAICCRLEPESRPA-----FS-KLED---SF--
--V-TLLRALGHGAFGEVYEGLVIG--LPGDSSPLQVAI-KTL---P-E--L-CS-PQD-EL-DFL-M----EALIISKF--R---HQNIVRCVGLSL--R------ATPRLILLELMSGGDMKSFLR----HSRP--------------------------------------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEEN--------HFIHRDIAARNCLLSCA--GPSRVA----KIGDFGMARDI-------------Y--R--ASYY------------RRGDRALLPVKWMPPEAFL------EGI--FTSKTDSWSFGVLLWEIFSLGY--------------MP---------------YPGR-----TNQEVLDFV-VGGGRMD---PPRGCP-------------------------------GPVYR-IMTQCWQHEPELRPS-----FA-SILERL-----
---IKLVKRLGAGQFGEVWMGYYN--------NSTKVAV-KTL---K-P--G-TM-SV---Q-AFL-E----EANLMKTL--Q---HDKLVRLYAVVT--R------EEPIYIITEYMAKGSLLDFLK----SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERK--------NYIHRDLRAANVLVSE-----SLMC----KIADFGLARVI----------------E--DNEY------------TAREGAKFPIKWTAPEAIN------FGC--FTIKSDVWSFGILLYEIVTYGK--------------IP---------------YPGR-----TNADVMTAL-SQGYRMP---RVENCP-------------------------------DELYD-IMKMCWKEKAEERPT-----FD-YLQSV--L---
---YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAV-KKL---SRP--F-QSIIH---A-KRTYR----ELRLLKHM--K---HENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK----CQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSA--------DIIHRDLKPSNLAVNE-----DCEL----KILDFGLAR-------------------HTDDEM------------TG---YVATRWYRAPEIML-----NWMH--YNQTVDIWSVGCIMAELLT-GR--------------TL---------------FPGT-----DHIDQLKLI-LRLVGTP---GAELLKKISSESARNYIQSLTQMP-KMNFANVFIGANPLAVD-LLEKMLVLDSDKRIT-----AA-QALAHAYF---
---YRLLKTIGKGNFAKVKLARHI-------LTGKEVAV-KII---DKT--Q-LNSSS---L-QKLFR----EVRIMKVL--N---HPNIVKLFEVIE--T------EKTLYLVMEYASGGEVFDYLV---AHG----------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVQYCHQK--------FIVHRDLKAENLLLDA-----DMNI----KIADFGFSNE-----------------FTFGNKL------------DT---FCGSPPYAAPELFQ-----GKKY--DGPEVDVWSLGVILYTLVS-GS--------------LP---------------FDGQ--------NLKELR-ERVLRGK---YRIPFYMS-----------------------------TDCEN-LLKKFLILNPSKRGT-----LE-QIMKDRWM---
---YRLLRTIGKGNFAKVKLARHI-------LTGREVAI-KII---DKT--Q-LNPSS---L-QKLFR----EVRIMKGL--N---HPNIVKLFEVIE--T------EKTLYLVMEYASAGEVFDYLV---SHG----------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVHYCHQK--------NIVHRDLKAENLLLDA-----EANI----KIADFGFSNE-----------------FTLGSKL------------DT---FCGSPPYAAPELFQ-----GKKY--DGPEVDIWSLGVILYTLVS-GS--------------LP---------------FDGH--------NLKELR-ERVLRGK---YRVPFYMS-----------------------------TDCES-ILRRFLVLNPAKRCT-----LE-QIMKDKWI---
---YELHETIGTGGFAKVKLACHI-------LTGEMVAI-KIM---DKN--T-LGSDL---P-RIKT-----EIEALKNL--R---HQHICQLYHVLE--T------ANKIFMVLEYCPGGELFDYII---SQD----------------------------------------------------------------------------------------------------RLSEEETRVVFRQIVSAVAYVHSQ--------GYAHRDLKPENLLFDE-----YHKL----KLIDFGLCAKP---------------KGNKDYHL------------QT---CCGSLAYAAPELIQ-----GKSY--LGSEADVWSMGILLYVLMC-GF--------------LP---------------FDDD--------NVMALY-KKIMRGK---YDVPKWLS-----------------------------PSSIL-LLQQMLQVDPKKRIS-----MK-NLLNHPWI---
---YDVIKAIGQGAFGKAYLAKGK-------SDSKHCVI-KEI---NFE--K-MPIQE---K-EASKK----EVILLEKM--K---HPNIVAFFNSFQ--E------NGRLFIVMEYCDGGDLMKRINR-QRGV----------------------------------------------------------------------------------------------------LFSEDQILGWFVQISLGLKHIHDR--------KILHRDIKAQNIFLSK-----NGMV---AKLGDFGIARVL----------------NNSMELA------------RT---CIGTPYYLSPEICQ------NKP--YNNKTDIWSLGCVLYELCT-LK--------------HP---------------FEGN--------NLQQLV-LKICQAH---FAPISPGF---S-------------------------RELHS-LISQLFQVSPRDRPS-----IN-SILKRPFL---
---YELQETLGKGTYGKVKRATER-------FSGRVVAI-KSI---RKD--K-IKDEQ---D-MVHIR---REIEIMSSL--N---HPHIISIYEVFE--N------KDKIVIIMEYASKGELYDYIS---ERR----------------------------------------------------------------------------------------------------RLSERETRHFFRQIVSAVHYCHKN--------GVVHRDLKLENILLDD-----NCNI----KIADFGLSNL-----------------YQKDKFL------------QT---FCGSPLYASPEIVN-----GRPY--RGPEVDSWALGVLLYTLVY-GT--------------MP---------------FDGF--------DHKNLI-RQISSGE---YREPTQP------------------------------SDARG-LIRWMLMVNPDRRAT-----IE-DIANHWW-V--
---YEFLETLGKGTYGKVKKARES-------SGR-LVAI-KSI---RKD--K-IKDEQ---D-LMHIR---REIEIMSSL--N---HPHIIAIHEVFE--N------SSKIVIVMEYASRGDLYDYIS---ERQ----------------------------------------------------------------------------------------------------QLSEREARHFFRQIVSAVHYCHQN--------RVVHRDLKLENILLDA-----NGNI----KIADFGLSNL-----------------YHQGKFL------------QT---FCGSPLYASPEIVN-----GKPY--TGPEVDSWSLGVLLYILVH-GT--------------MP---------------FDGH--------DHKILV-KQISNGA---YREPPK-----P-------------------------SDACG-LIRWLLMVNPTRRAT-----LE-DVASHWW-V--
--L-VLGRVLGSGAFGKVVEGTAYG--LSRSQPVMKVAV-KML---K-P--T-AR-SSE-KQ-ALM-S----ELKIMTHLG-P---HLNIVNLLGACT--K------SGPIYIITEYCFYGDLVNYLH----KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASK--------NCVHRDLAARNVLLAQ-----GKIV----KICDFGLARDI-------------M--H--DSNY------------VSKGSTFLPVKWMAPESIF------DNL--YTTLSDVWSYGILLWEIFSLGG--------------TP---------------YPGM-M---VDSTFYNKI-KSGYRMA---KPDHAT-------------------------------SEVYE-IMVKCWNSEPEKRPS-----FY-HLSE---IV--
--L-VLGRTLGSGAFGQVVEATAHG--LSHSQATMKVAV-KML---K-S--T-AR-SSE-KQ-ALM-S----ELKIMSHLG-P---HLNVVNLLGACT--K------GGPIYIITEYCRYGDLVDYLH----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASK--------NCVHRDLAARNVLICE-----GKLV----KICDFGLARDI-------------M--R--DSNY------------ISKGSTFLPLKWMAPESIF------NSL--YTTLSDVWSFGILLWEIFTLGG--------------TP---------------YPEL-P---MNEQFYNAI-KRGYRMA---QPAHAS-------------------------------DEIYE-IMQKCWEEKFEIRPP-----FS-QLVL---LL--
-FR--CCAVLGRGHFGKVLLAEYK-------NTNEMFAI-KAL---KKG--D-IVARD---E-VDSLM---CEKRIFETV--NSVRHPFLVNLFACFQ--T------KEHVCFVMEYAAGGDLMMHIH----TD----------------------------------------------------------------------------------------------------VFSEPRAVFYAACVVLGLQYLHEH--------KIVYRDLKLDNLLLDT-----EGFV----KIADFGLCKEG----------------MGYGDRT------------ST---FCGTPEFLAPEVLT------ETS--YTRAVDWWGLGVLIYEMLV-GE--------------SP---------------FPGD--------DEEEVF-DSIVNDE---VRYPRFLS-----------------------------TEAIS-IMRRLLRRNPERRLGASEKDAE-DVKKHPFF---
--Y-ILGDTLGVGTFGKVKVGKHE-------LTGHKVAV-KIL---NRQ--K-IRSLD---V-VGKIR---REIQNLKLF--R---HPHIIKLYQVIS--T------PSDIFMVMEYVSGGELFDYIC---KNG----------------------------------------------------------------------------------------------------RLDEKESRRLFQQILSGVDYCHRH--------MVVHRDLKPENVLLDA-----HMNA----KIADFGLSNM-----------------MSDGEFL------------RT---SCGSPNYAAPEVIS-----GRLY--AGPEVDIWSSGVILYALLC-GT--------------LP---------------FDDD--------HVPTLF-KKICDGI---FYTPQYLN-----------------------------PSVIS-LLKHMLQVDPMKRAT-----IK-DIREHEWF---
---YVLGDTLGVGTFGKVKIGEHQ-------LTGHKVAV-KIL---NRQ--K-IRSLD---V-VGKIK---REIQNLKLF--R---HPHIIKLYQVIS--T------PTDFFMVMEYVSGGELFDYIC---KHG----------------------------------------------------------------------------------------------------RVEEMEARRLFQQILSAVDYCHRH--------MVVHRDLKPENVLLDA-----HMNA----KIADFGLSNM-----------------MSDGEFL------------RT---SCGSPNYAAPEVIS-----GRLY--AGPEVDIWSCGVILYALLC-GT--------------LP---------------FDDE--------HVPTLF-KKIRGGV---FYIPEYLN-----------------------------RSVAT-LLMHMLQVDPLKRAT-----IK-DIREHEWF---
-FI--FHKVLGKGSFGKVLLGELK-------GRGEYFAI-KAL---KKD--V-VLIDD---D-VECTM---VEKRVLTLA-AE---NPFLTHLICTFQ--T------KDHLFFVMEFLNGGDLMYHIQ---DKG----------------------------------------------------------------------------------------------------RFELYRATFYAAEIMCGLQFLHSK--------GIIYRDLKLDNVLLDR-----DGHI----KIADFGMCKEN----------------IFGESRA------------ST---FCGTPDYIAPEILQ------GLK--YTFSVDWWSFGVLLYEMLI-GQ--------------SP---------------FHGD--------DEDELF-ESIRVDT---PHYPRWIT-----------------------------KESKD-ILEKLFEREPTKRLG----VTG-NIKIHPFF---
-FI--LHKMLGKGSFGKVFLAEFK-------KTNQFFAI-KAL---KKD--V-VLMDD---D-VECTM---VEKRVLSLA-WE---HPFLTHMFCTFQ--T------KENLFFVMEYLNGGDLMYHIQ---SCH----------------------------------------------------------------------------------------------------KFDLSRATFYAAEIILGLQFLHSK--------GIVYRDLKLDNILLDK-----DGHI----KIADFGMCKEN----------------MLGDAKT------------NT---FCGTPDYIAPEILL------GQK--YNHSVDWWSFGVLLYEMLI-GQ--------------SP---------------FHGQ--------DEEELF-HSIRMDN---PFYPRWLE-----------------------------KEAKD-LLVKLFVREPEKRLG-----VRGDIRQHPLF---
--L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAV-KML---K-E--N-AS-PSE-LR-DLL-S----EFNVLKQV--N---HPHVIKLYGACS--Q------DGPLLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM--------KLVHRDLAARNILVAE-----GRKM----KISDFGLSRDV-------------Y--E--EDSY------------VKRSQGRIPVKWMAIESLF------DHI--YTTQSDVWSFGVLLWEIVTLGG--------------NP---------------YPGI-----PPERLFNLL-KTGHRME---RPDNCS-------------------------------EEMYR-LMLQCWKQEPDKRPV-----FA-DISKDL-----
LES----AELDSGGFGKVSLCFHR--------TQGLMIM-KTV--YK-G--P-NC-IEH-NE-ALL-E----EAKMMNRL--R---HSRVVKLLGVII--E------EGKYSLVMEYMEKGNLMHVLK----AE---------------------------------------------------------------------------------------------------MSTPLSVKGRIILEIIEGMCYLHGK--------GVIHKDLKPENILVDN-----DFHI----KIADLGLASFKMWS------KLNNE------EHNELR------EVDGTAKKNGGTLYYMAPEHLN------DVNAKPTEKSDVYSFAVVLWAIFA-NK--------------EP---------------YENA-I---CEQQLIMCI-KSGNRPDVDDITEYCP-------------------------------REIIS-LMKLCWEANPEARPT-----FP-GIEEK--F---
-LT--LRLLLGSGAFGEVYEGTAVDI-LGVGSGEIKVAV-KTL---K-K--G-ST-DQE-KI-EFL-K----EAHLMSKF--N---HPNILKQLGVCL--L------NEPQYIILELMEGGDLLTYLR----KARM--------------------------------------------------------------------------------------------ATFYGPLLTLVDLVDLCVDISKGCVYLERM--------HFIHRDLAARNCLVSVKDYTSPRIV----KIGDFGLARDI-------------Y--K--NDYY------------RKRGEGLLPVRWMAPESLM------DGI--FTTQSDVWSFGILIWEILTLGH--------------QP---------------YPAH-----SNLDVLNYV-QTGGRLE---PPRNCP-------------------------------DDLWN-LMTQCWAQEPDQRPT-----FH-RIQDQL-----
---YDIERTLGKGNFAVVKLARHR-------VTKTQVAI-KII---DKT--R-LDSSN---L-EKIYR----EVQLMKLL--N---HPHIIKLYQVME--T------KDMLYIVTEFAKNGEMFDYLT---SNG----------------------------------------------------------------------------------------------------HLSENEARKKFWQILSAVEYCHDH--------HIVHRDLKTENLLLDG-----NMDI----KLADFGFGNF-----------------YKSGEPL------------ST---WCGSPPYAAPEVFE-----GKEY--EGPQLDIWSLGVVLYVLVC-GS--------------LP---------------FDGP--------NLPTLR-QRVLEGR---FRIPFFMS-----------------------------QDCES-LIRRMLVVDPARRIT-----IA-QIRQHRWM---
---YDIEGTLGKGNFAVVKLGRHR-------ITKTEVAI-KII---DKS--Q-LDAVN---L-EKIYR----EVQIMKML--D---HPHIIKLYQVME--T------KSMLYLVTEYAKNGEIFDYLA---NHG----------------------------------------------------------------------------------------------------RLNESEARRKFWQILSAVDYCHGR--------KIVHRDLKAENLLLDN-----NMNI----KIADFGFGNF-----------------FKSGELL------------AT---WCGSPPYAAPEVFE-----GQQY--EGPQLDIWSMGVVLYVLVC-GA--------------LP---------------FDGP--------TLPILR-QRVLEGR---FRIPYFMS-----------------------------EDCEH-LIRRMLVLDPSKRLT-----IA-QIKEHKWM---
--L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAI-KTL---K-P--G-TM-SP---E-AFL-Q----EAQVMKKL--R---HEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK----GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVGE-----NLVC----KVADFGLARLI----------------E--DNEY------------TARQGAKFPIKWTAPEAAL------YGR--FTIKSDVWSFGILLTELTTKGR--------------VP---------------YPGM-----VNREVLDQV-ERGYRMP---CPPECP-------------------------------ESLHD-LMCQCWRKEPEERPT-----FE-YLQAF--L---
---FTKLEKIGKGSFGEVFKGIDN-------RTQKVVAI-KII---DLE--E-AEDEI---E-DIQ-Q----EITVLSQC--D---SPYVTKYYGSYL--K------DTKLWIIMEYLGGGSALDLLE----PG----------------------------------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSE--------KKIHRDIKAANVLLSE-----HGEV----KLADFGVAGQL----------------TDTQIKR------------NT---FVGTPFWMAPEVIK------QSA--YDSKADIWSLGITAIELAR-GE--------------PP---------------HSEL-----HPMKVLFLI-PKNNPPT---LEGNYS-------------------------------KPLKE-FVEACLNKEPSFRPT-----AK-ELLKHKFI---
TLE---DKELGSGNFGTVKKGYYQ-----MKKVVKTVAV-KIL---K-N--E-AN-DPALKD-ELL-A----EANVMQQL--D---NPYIVRMIGICE---------AESWMLVMEMAELGPLNKYLQ----QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEES--------NFVHRDLAARNVLLVT-----QHYA----KISDFGLSKAL-------------R--A--DENY-----------YKAQTHGKWPVKWYAPECIN------YYK--FSSKSDVWSFGVLMWEAFSYGQ--------------KP---------------YRGM-----KGSEVTAML-EKGERMG---CPAGCP-------------------------------REMYD-LMNLCWTYDVENRPG-----FA-AVE----LRL-
---LTFMRELGSGLFGVVRLGKWR--------AQYKVAI-KAI---R-E--G-AM-CE---E-DFI-E----EAKVMMKL--T---HPKLVQLYGVCT--Q------QKPIYIVTEFMERGCLLNFLR----QR--------------------------------------------------------------------------------------------------QGHFSRDVLLSMCQDVCEGMEYLERN--------SFIHRDLAARNCLVSE-----AGVV----KVSDFGMARYV----------------L--DDQY------------TSSSGAKFPVKWCPPEVFN------YSR--FSSKSDVWSFGVLMWEVFTEGR--------------MP---------------FEKY-----TNYEVVTMV-TRGHRLY---QPKLAS-------------------------------NYVYE-VMLRCWQEKPEGRPS-----FE-DLLRT--I---
---IKFQDVIGEGNFGQVLKARIK-----KDGLRMDAAI-KRM---K-E--Y-AS-KDD-HR-DFA-G----ELEVLCKLG-H---HPNIINLLGACE--H------RGYLYLAIEYAPHGNLLDFLR----KSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQK--------QFIHRDLAARNILVGE-----NYVA----KIADFGLSRGQ--------------------EVY------------VKKTMGRLPVRWMAIESLN------YSV--YTTNSDVWSYGVLLWEIVSLGG--------------TP---------------YCGM-----TCAELYEKL-PQGYRLE---KPLNCD-------------------------------DEVYD-LMRQCWREKPYERPS-----FA-QILV---SL--
-IV--LQESIGKGRFGEVWRGKWR-------GEE--VAV-KIF---SSR--E-ERSWF---R-EA-------EIYQTVML--R---HENILGFIAADN--KDN--GTWTQLWLVSDYHEHGSLFDYLN----RY----------------------------------------------------------------------------------------------------TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKK-----NGTC----CIADLGLAVRHDS------------ATDTIDIAP------------NH---RVGTKRYMAPEVLDDSINMKHFE--SFKRADIYAMGLVFWEIAR-RCSIGGI----HEDYQLP---------------YYDLVPSDPSVEEMRKVV-CEQKLRP---NIPNRWQSCEAL-------------------------RVMAK-IMRECWYANGAARLT-----AL-RIKK----TL-
---ITFEDLIGEGNFGQVIRAMIK-----KDGLKMNAAI-KML---K-E--Y-AS-END-HR-DFA-G----ELEVLCKLG-H---HPNIINLLGACK--N------RGYLYIAIEYAPYGNLLDFLR----KSRVLETDP-----------------------------------------------------------------------------------AFAREHGTASTLSSRQLLRFASDAANGMQYLSEK--------QFIHRDLAARNVLVGE-----NLAS----KIADFGLSRGE--------------------EVY------------VKKTMGRLPVRWMAIESLN------YSV--YTTKSDVWSFGVLLWEIVSLGG--------------TP---------------YCGM-----TCAELYEKL-PQGYRME---QPRNCD-------------------------------DEVYE-LMRQCWRDRPYERPP-----FA-QIALQ--L---
VCR---GELLGSGCFGVVHRGLWT----LPSGKSVPVAV-KSLRVGP-E--G-PM-GTE-LG-DFL-R----EVSVMMNL--E---HPHVLRLHGLVL---------GQPLQMVMELAPLGSLHARLT----AP------------------------------------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGAR--------GLVHRDLATRNLLLAS-----PRTI----KVADFGLVRPL------------GG--A--RGRY------------VMGGPRPIPYAWCAPESLR------HGA--FSSASDVWMFGVTLWEMFSGGE--------------EP---------------WAGV-----PPYLILQRL-EDRARLP---RPPLCS-------------------------------RALYS-LALRCWAPHPADRPS-----FS-HLE----GLL-
--L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAV-KCL---K-PDVL-SQ-PEA-MD-DFI-R----EVNAMHSL--D---HRNLIRLYGVVL---------TPPMKMVTELAPLGSLLDRLR----KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK--------RFIHRDLAARNLLLAT-----RDLV----KIGDFGLMRAL------------PQ--N--DDHY------------VMQEHRKVPFAWCAPESLK------TRT--FSHASDTWMFGVTLWEMFTYGQ--------------EP---------------WIGL-----NGSQILHKIDKEGERLP---RPEDCP-------------------------------QDIYN-VMVQCWAHKPEDRPT-----FV-ALRDF--L---
--L-AFIKEIGSGQFGVVHLGEWR--------SHIQVAI-KAI---N-E--G-SM-SE---E-DFI-E----EAKVMMKL--S---HSKLVQLYGVCI--Q------RKPLYIVTEFMENGCLLNYLR----EN--------------------------------------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLERN--------GYIHRDLAARNCLVSS-----TCIV----KISDFGMTRYV----------------L--DDEY------------VSSFGAKFPIKWSPPEVFL------FNK--YSSKSDVWSFGVLMWEVFTEGK--------------MP---------------FENK-----SNLQVVEAI-SEGFRLY---RPHLAP-------------------------------MSIYE-VMYSCWHEKPEGRPT-----FA-ELLR---AV--
--L-RLEVKLGQGCFGEVWMGTWN--------GTTKVAI-KTL---K-P--G-TM-MP---E-AFL-Q----EAQIMKKL--R---HDKLVPLYAVVS---------EEPIYIVTEFMSKGSLLDFLK----EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERM--------NYIHRDLRAANILVGE-----NLVC----KIADFGLARLI----------------E--DNEY------------TARQGAKFPIKWTAPEAAL------YGR--FTIKSDVWSFGILQTELVTKGR--------------VP---------------YPGM-----VNREVLEQV-ERGYRMP---CPQGCP-------------------------------ESLHE-LMNLCWKKDPDERPT-----FE-YIQSFL-----
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