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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PKN1 203
TK ABL1 261
TK ABL2 288
AGC AKT1 150
Other AURKA 133
Other AURKB 77
TK BLK 241
Other CAMKK2 165
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
CMGC CDK6 13
CMGC CDK9 2.7.11.23
CAMK CHEK1 9
CMGC CLK1 161
CMGC CLK2 163
CMGC CLK4 159
CMGC CSNK2A2 40
CMGC DYRK1A 150
CMGC DYRK1B 111
CMGC DYRK2 222
TK EPHB1 619
TK FGFR1 478
TK FGR 263
TK FYN 271
CMGC GSK3B 56
TKL IRAK4 186
TK ITK 363
TK JAK2 849
TK JAK3 822
TK LCK 245
TK LYN 247
STE MAP2K1 68
TKL MAP3K7 36
CMGC MAPK10 64
CMGC MAPK8 26
CMGC MAPK9 26
CAMK MARK4 59
TK MET 1078
TK MUSK 575
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
AGC PDPK1 82
CAMK PHKG1 20
CAMK PHKG2 24
Other PLK1 53
AGC PRKCA 339
AGC PRKCD 349
AGC PRKCQ 380
TK PTK6 191
AGC RPS6KA1 62
AGC RPS6KB1 91
CAMK SIK2 20
TK SRC 270
STE STK10 36
CAMK STK17A 61
CAMK STK33 116
TK TNK2 150
TK YES1 277
TKL ZAK 16
TK ZAP70 338
---F-KFLAVLGRGHFGKV---LLSEF---R-------P-S-GE-LFAIKALKKG--D-IVA---RD--E-V-ESLM------------------------CEKRILAAV--TS---AGHPF-----LVNLFGCFQ--T--------PEHVC--FVMEYSAGG--DLMLHIH-----SD--------------------------VF---SEPRAIFYSACVVLGLQFLHE--H---K---IVYRDLKLDNLLLD--TEG-YV-------------------KIADFGLCKEG-------MGYGDRT--------------ST---FCGTPEFLAPEVLT------DTS--YTRAVDWWGLGVLLYEMLV-GESP---------------FP-GD-----DEEEVF-DSIVNDEVRYPRFLS-------------------------------------------------------------AEAIG-IMRRLLRRNPERRLGSSERDAE-DVKKQPFF--------------
----ITMKHKLGGGQYGEV---YEGVW---K-------K-Y-SL-TVAVKTLK-E--D-TM----EV--E-E-FL-K-------------------------EAAVMKEI--K------HPN-----LVQLLGVCT--R--------EPPFY--IITEFMTYG--NLLDYLR-----EC----------------------NR-QEV---NAVVLLYMATQISSAMEYLEK--K---N---FIHRDLAARNCLVG--ENH-LV-------------------KVADFGLSRLM-------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNK--FSIKSDVWAFGVLLWEIATYGMSP---------------YP-GI--DLSQVYELL-EKDYRMERPEGCP---------------------------------------------------------------EKVYE-LMRACWQWNPSDRPS-----FA-EIHQA--F--------------
----ITMKHKLGGGQYGEV---YVGVW---K-------K-Y-SL-TVAVKTLK-E--D-TM----EV--E-E-FL-K-------------------------EAAVMKEI--K------HPN-----LVQLLGVCT--L--------EPPFY--IVTEYMPYG--NLLDYLR-----EC----------------------NR-EEV---TAVVLLYMATQISSAMEYLEK--K---N---FIHRDLAARNCLVG--ENH-VV-------------------KVADFGLSRLM-------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNT--FSIKSDVWAFGVLLWEIATYGMSP---------------YP-GI--DLSQVYDLL-EKGYRMEQPEGCP---------------------------------------------------------------PKVYE-LMRACWKWSPADRPS-----FA-ETHQA--F--------------
---F-EYLKLLGKGTFGKV---ILVKE---K-------A-T-GR-YYAMKILKKE--V-IVA---KD--E-V-AHTL------------------------TENRVLQNS--R------HPF-----LTALKYSFQ--T--------HDRLC--FVMEYANGG--ELFFHLS----RER--------------------------VF---SEDRARFYGAEIVSALDYLHS-EK---N---VVYRDLKLENLMLD--KDG-HI-------------------KITDFGLCKEG-------IKDGATM--------------KT---FCGTPEYLAPEVLE------DND--YGRAVDWWGLGVVMYEMMC-GRLP---------------FY-NQ-----DHEKLF-ELILMEEIRFPRTLG-------------------------------------------------------------PEAKS-LLSGLLKKDPKQRLGGGSEDAK-EIMQHRFF--------------
----FEIGRPLGKGKFGNV---YLARE---K-------Q-S-KF-ILALKVLFKA--QLEKA---GV--E-H-QLRR-------------------------EVEIQSHL--R------HPN-----ILRLYGYFH--D--------ATRVY--LILEYAPLG--TVYRELQ----KLS--------------------------KF---DEQRTATYITELANALSYCHS--K---R---VIHRDIKPENLLLG--SAG-EL-------------------KIADFGWSV---------HAPSSRR--------------TT---LCGTLDYLPPEMIE------GRM--HDEKVDLWSLGVLCYEFLV-GKPP---------------FE-AN-----TYQETY-KRISRVEFTFPDFVT-------------------------------------------------------------EGARD-LISRLLKHNPSQRPM-----LR-EVLEHPWI--------------
----FEIGRPLGKGKFGNV---YLARE---K-------K-S-HF-IVALKVLFKS--Q-IEK---EG--V-E-HQLR------------------------REIEIQAHL--H------HPN-----ILRLYNYFY--D--------RRRIY--LILEYAPRG--ELYKELQ----KSC--------------------------TF---DEQRTATIMEELADALMYCHG--K---K---VIHRDIKPENLLLG--LKG-EL-------------------KIADFGWSV---------HAPSLRR--------------KT---MCGTLDYLPPEMIE------GRM--HNEKVDLWCIGVLCYELLV-GNPP---------------FE-SA-----SHNETY-RRIVKVDLKFPASVP-------------------------------------------------------------MGAQD-LISKLLRHNPSERLP-----LA-QVSAHPWV--------------
---L-RLVRKLGSGQFGEV---WMGYY---K---------N-NM-KVAIKTLK-E--G-TM----SP--E-A-FL-G-------------------------EANVMKAL--Q------HER-----LVRLYAVVT-----------KEPIY--IVTEYMARG--CLLDFLK-----TD----------------------EG-SRL---SLPRLIDMSAQIAEGMAYIER--M---N---SIHRDLRAANILVS--EAL-CC-------------------KIADFGLARII----------DSEY--------------TAQEGAKFPIKWTAPEAIH------FGV--FTIKADVWSFGVLLMEVVTYGRVP---------------YP-GM--SNPEVIRNL-ERGYRMPRPDTCP---------------------------------------------------------------PELYRGVIAECWRSRPEERPT-----FE-FLQSV--L--------------
----YTLKDEIGKGSYGVV---KLAYN---E-------N-D-NT-YYAMKVLSKK--K-LIR---QA--G-F-PR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL--D------HPN-----VVKLVEVLD--DP------NEDHLY--MVFELVNQG--PVMEVPT-----LK--------------------------PL---SEDQARFYFQDLIKGIEYLHY--Q---K---IIHRDIKPSNLLVG--EDG-HI-------------------KIADFGVSNEF-------KGSDALL--------------SN---TVGTPAFMAPESLS-----ETRKIFSGKALDVWAMGVTLYCFVF-GQCP---------------FM-DE-----RIMCLH-SKIKSQALEFPDQPDIA-----------------------------------------------------------EDLKD-LITRMLDKNPESRIV-----VP-EIKLHPWV--------------
----YTKIEKIGEGTYGVV---YKGRH---K-------T-T-GQ-VVAMKKIRLE--S-EEE---GV--P-S-TAIR-------------------------EISLLKEL--R------HPN-----IVSLQDVLM--Q--------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ--------------------------YM---DSSLVKSYLYQILQGIVFCHS--R---R---VLHRDLKPQNLLID--DKG-TI-------------------KLADFGLARAF-------GIPIRVY--------------TH---EVVTLWYRSPEVLL-----GSAR--YSTPVDIWSIGTIFAELAT-KKPL---------------FH-GD--SEIDQLFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-----GK-MALNHPYF--------------
----FQKVEKIGEGTYGVV---YKARN---K-------L-T-GE-VVALKKIRLD--T-ETE---GV--P-S-TAIR-------------------------EISLLKEL--N------HPN-----IVKLLDVIH--T--------ENKLY--LVFEFLHQ---DLKKFMDA--SALT--------------------------GI---PLPLIKSYLFQLLQGLAFCHS--H---R---VLHRDLKPQNLLIN--TEG-AI-------------------KLADFGLARAF-------GVPVRTY--------------TH---EVVTLWYRAPEILL-----GCKY--YSTAVDIWSLGCIFAEMVT-RRAL---------------FP-GD--SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-----AK-AALAHPFF--------------
---Y-EPVAEIGVGAYGTV---YKARD---P-------H-S-GH-FVALKSVRVP--N-GGGGGGGL--P-I-STVR-------------------------EVALLRRL--EA---FEHPN-----VVRLMDVCA--TSR---TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP--------------------------GL---PAETIKDLMRQFLRGLDFLHA--N---C---IVHRDLKPENILVT--SGG-TV-------------------KLADFGLARI--------YSYQMAL--------------TP---VVVTLWYRAPEVLL------QST--YATPVDMWSVGCIFAEMFR-RKPL---------------FC-GN--SEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPR-------------------------------------PVQSVVPEMEESGAQ-LLLEMLTFNPHKRIS-----AF-RALQHSYL--------------
----YECVAEIGEGAYGKV---FKARD---L-------K-N-GGRFVALKRVRVQ--T-GEE---GM--P-L-STIR-------------------------EVAVLRHL--ET---FEHPN-----VVRLFDVCT--VSR---TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEP--------------------------GV---PTETIKDMMFQLLRGLDFLHS--H---R---VVHRDLKPQNILVT--SSG-QI-------------------KLADFGLARI--------YSFQMAL--------------TS---VVVTLWYRAPEVLL------QSS--YATPVDLWSVGCIFAEMFR-RKPL---------------FR-GS--SDVDQLGKI-LDVIGLPGEEDWPRDVALPRQAFHSKSAQ-------------------------------------PIEKFVTDIDELGKD-LLLKCLTFNPAKRIS-----AY-SALSHPYF--------------
----YEKLAKIGQGTFGEV---FKARH---R-------K-T-GQ-KVALKKVLME--N-EKE---GF--P-I-TALR-------------------------EIKILQLL--K------HEN-----VVNLIEICR--TKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLV--------------------------KF---TLSEIKRVMQMLLNGLYYIHR--N---K---ILHRDMKAANVLIT--RDG-VL-------------------KLADFGLARAFSL---AKNSQPNRY--------------TN---RVVTLWYRPPELLL-----GERD--YGPPIDLWGAGCIMAEMWT-RSPI---------------MQ-GN--TEQHQLALI-SQLCGSITPEVWPNVDNYELYEKLELVKGQK--------------------------------RKVKDRLKAYVRDPYALD-LIDKLLVLDPAQRID-----SD-DALNHDFF--------------
---W-DLVQTLGEGAYGEV---QLAVN---R-------V-T-EE-AVAVKIVDMK--R-AVD---CP--E-N-I-KK-------------------------EICINKML--N------HEN-----VVKFYGHRR--E--------GNIQY--LFLEYCSGG--ELFDRIE----PDI--------------------------GM---PEPDAQRFFHQLMAGVVYLHG--I---G---ITHRDIKPENLLLD--ERD-NL-------------------KISDFGLATVFR-----YNNRERLL--------------NK---MCGTLPYVAPELLK-----RREF--HAEPVDVWSCGIVLTAMLA-GELP---------------WD-QP----SDSCQEY-SDWKEKKTYLNPWKKI--D---------------------------------------------------------SAPLA-LLHKILVENPSARIT-----IP-DIKKDRW-Y-------------
----YEIVDTLGEGAFGKV---VECID---H-------K-AGGR-HVAVKIVKNV--D-RYC---EA--A-R-S----------------------------EIQVLEHL--NT----TDPNST-FRCVQMLEWFE--H--------HGHIC--IVFELLGL---STYDFIK----ENG--------------------------FLP-FRLDHIRKMAYQICKSVNFLHS--N---K---LTHTDLKPENILFV--QSD-YTEAYNPKIKRDERTLINPDIKVVDFGSA----------TYDDEHH--------------ST---LVSTRHYRAPEVIL------ALG--WSQPCDVWSIGCILIEYYL-GFTV---------------FP-TH--DSKEHLAMM-ERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRY--------------------VSRRCKPLKEFMLSQDVEHERLFD-LIQKMLEYDPAKRIT-----LR-EALKHPFF--------------
----YEIVSTLGEGTFGRV---VQCVD---H-------R-R-GGARVALKIIKNV--E-KYK---EA--A-R----L-------------------------EINVLEKI--NEK-DPDNKN----LCVQMFDWFD--Y--------HGHMC--ISFELLGL---STFDFLK----DNN--------------------------YLP-YPIHQVRHMAFQLCQAVKFLHD--N---K---LTHTDLKPENILFV--NSD-YELTYNLEKKRDERSVKSTAVRVVDFGSAT----------FDHEHH--------------ST---IVSTRHYRAPEVIL------ELG--WSQPCDVWSIGCIIFEYYV-GFTL---------------FQ-TH--DNREHLAMM-ERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY--------------------VRENCKPLRRYLTSEAEEHHQLFD-LIESMLEYEPAKRLT-----LG-EALQHPFF--------------
----YEIVDTLGEGAFGKV---VECID---H-------GMD-GM-HVAVKIVKNV--G-RYR---EA--A-R-S----------------------------EIQVLEHL--NS----TDPNSV-FRCVQMLEWFD--H--------HGHVC--IVFELLGL---STYDFIK----ENS--------------------------FLP-FQIDHIRQMAYQICQSINFLHH--N---K---LTHTDLKPENILFV--KSD-YVVKYNSKMKRDERTLKNTDIKVVDFGSA----------TYDDEHH--------------ST---LVSTRHYRAPEVIL------ALG--WSQPCDVWSIGCILIEYYL-GFTV---------------FQ-TH--DSKEHLAMM-ERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRY--------------------VRRRCKPLKEFMLCHDEEHEKLFD-LVRRMLEYDPTQRIT-----LD-EALQHPFF--------------
----YQLVRKLGRGKYSEV---FEAIN---I-------T-N-NE-RVVVKILKPV--K-KKK---IK--R--------------------------------EVKILENL-RG------GTN-----IIKLIDTVK--DP------VSKTPA--LVFEYINNT--DFKQLY-------Q--------------------------IL---TDFDIRFYMYELLKALDYCHS--K---G---IMHRDVKPHNVMID-HQQK-KL-------------------RLIDWGLAEF--------YHPAQEY--------------NV---RVASRYFKGPELLV-----DYQM--YDYSLDMWSLGCMLASMIF-RREP---------------FFHGQ--DNYDQLVRI-AKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRK---------------------------RWENFIHSENRHLVSPEALD-LLDKLLRYDHQQRLT-----AK-EAMEHPYF--------------
----YEIDSLIGKGSFGQV---VKAYD---R-------V-E-QE-WVAIKIIKNK--K-AFL---NQ--A-Q-I----------------------------EVRLLELM-NK------HDTEMKYYIVHLKRHFM--F--------RNHLC--LVFEMLSY---NLYDLLR-----NT--------------------------NFRGVSLNLTRKFAQQMCTALLFLATPEL---S---IIHCDLKPENILLCNPKRS-AI-------------------KIVDFGSSCQ----------LGQRI--------------YQ---YIQSRFYRSPEVLL------GMP--YDLAIDMWSLGCILVEMHT-GEPL---------------FS-GA--NEVDQMNKI-VEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKD-LILRMLDYDPKTRIQ-----PY-YALQHSFF--------------
----YEIDSLIGKGSFGQV---VKAYD---H-------Q-T-QE-LVAIKIIKNK--K-AFL---NQ--A-Q-I----------------------------ELRLLELM-NQ------HDTEMKYYIVHLKRHFM--F--------RNHLC--LVFELLSY---NLYDLLR-----NT--------------------------HFRGVSLNLTRKLAQQLCTALLFLATPEL---S---IIHCDLKPENILLCNPKRS-AI-------------------KIVDFGSSCQ----------LGQRI--------------YQ---YIQSRFYRSPEVLL------GTP--YDLAIDMWSLGCILVEMHT-GEPL---------------FS-GS--NEVDQMNRI-VEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQD-LVLRMLEYEPAARIS-----PL-GALQHGFF--------------
----YEVLKVIGKGSFGQV---VKAYD---H-------K-V-HQ-HVALKMVRNE--K-RFH---RQ--A-A-E----------------------------EIRILEHL--RKQDKDNTMN-----VIHMLENFT--F--------RNHIC--MTFELLSM---NLYELIKK--NKFQ--------------------------GF---SLPLVRKFAHSILQCLDALHK--N---R---IIHCDLKPENILLK--QQG-RSG-----------------IKVIDFGSSC----------YEHQRV--------------YT---YIQSRFYRAPEVIL------GAR--YGMPIDMWSLGCILAELLT-GYPL---------------LP-GE--DEGDQLACM-IELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNG-----GRSRRGKLRGPPESREWGNALKGCDDPLFLD-FLKQCLEWDPAVRMT-----PG-QALRHPWL--------------
---V-KIEEVIGAGEFGEV---YKGRL---K----LPGK-R-EI-YVAIKTLK-A--G-YS----EKQRR-D-FL-S-------------------------EASIMGQF--D------HPN-----IIRLEGVVT--K--------SRPVM--IITEFMENG--ALDSFLR-----QN-----------------------D-GQF---TVIQLVGMLRGIAAGMKYLAE--M---N---YVHRDLAARNILVN--SNL-VC-------------------KVSDFGLSRYLQ-DDT--S--DPTY--------------TSSLGGKIPVRWTAPEAIA------YRK--FTSASDVWSYGIVMWEVMSFGERP---------------YW-DM--SNQDVINAI-EQDYRLPPPMDCP---------------------------------------------------------------AALHQ-LMLDCWQKDRNSRPR-----FA-EIVNTL----------------
---L-VLGKPLGEGCFGQV---VLAEA---IGLDKDKPN-R-VT-KVAVKMLK-S--D-AT----EKDLS-D-LI-S-------------------------EMEMMKMIG-K------HKN-----IINLLGACT--Q--------DGPLY--VIVEYASKG--NLREYLQ-----ARRPPGLEY--------CYNPSHNPE-EQL---SSKDLVSCAYQVARGMEYLAS--K---K---CIHRDLAARNVLVT--EDN-VM-------------------KIADFGLARDI----H--H--IDYY--------------KKTTNGRLPVKWMAPEALF------DRI--YTHQSDVWSFGVLLWEIFTLGGSP---------------YP-GV--PVEELFKLL-KEGHRMDKPSNCT---------------------------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FK-QLVEDL----------------
----ITLERRLGTGCFGDV---WLGTW---N---------G-ST-KVAVKTLK-P--G-TM----SP--K-A-FL-E-------------------------EAQVMKLL--R------HDK-----LVQLYAVVS-----------EEPIY--IVTEFMCHG--SLLDFLK-----NP----------------------EG-QDL---RLPQLVDMAAQVAEGMAYMER--M---N---YIHRDLRAANILVG--ERL-AC-------------------KIADFGLARLI-------K--DDEY--------------NPCQGSKFPIKWTAPEAAL------FGR--FTIKSDVWSFGILLTELITKGRIP---------------YP-GM--NKREVLEQV-EQGYHMPCPPGCP---------------------------------------------------------------ASLYE-AMEQTWRLDPEERPT-----FE-YLQSFL----------------
----LQLIKRLGNGQFGEV---WMGTW---N---------G-NT-KVAIKTLK-P--G-TM----SP--E-S-FL-E-------------------------EAQIMKKL--K------HDK-----LVQLYAVVS-----------EEPIY--IVTEYMNKG--SLLDFLK-----DG----------------------EG-RAL---KLPNLVDMAAQVAAGMAYIER--M---N---YIHRDLRSANILVG--NGL-IC-------------------KIADFGLARLI-------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR--FTIKSDVWSFGILLTELVTKGRVP---------------YP-GM--NNREVLEQV-ERGYRMPCPQDCP---------------------------------------------------------------ISLHE-LMIHCWKKDPEERPT-----FE-YLQSFL----------------
----YTDTKVIGNGSFGVV---YQAKL---C-------D-S-GE-LVAIKKVLQD--K-RFK---NR-----------------------------------ELQIMRKL--D------HCN-----IVRLRYFFY--SSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ--------------------------TL---PVIYVKLYMYQLFRSLAYIHS--F---G---ICHRDIKPQNLLLD-PDTA-VL-------------------KLCDFGSAKQ--------LVRGEPN--------------VS---YICSRYYRAPELIF-----GATD--YTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD--SGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIA-LCSRLLEYTPTARLT-----PL-EACAHSFF--------------
-VGG----NKMGEGGFGVV---YKGYV---N-------N-T-T---VAVKKLAAM--V-DIT---TE--ELK-QQFD------------------------QEIKVMAKC--Q------HEN-----LVELLGFSS--D--------GDDLC--LVYVYMPNG--SLLDRLSC-LDGTP--------------------------PL---SWHMRCKIAQGAANGINFLHE--N---H---HIHRDIKSANILLD--EAF-TA-------------------KISDFGLARASE-----KFAQTVMT--------------SR---IVGTTAYMAPEALR-------GE--ITPKSDIYSFGVVLLEIIT-GLPA---------------VD-EH--REPQLLLDI-KEEIEDEEKTIEDYIDKKMNDAD-------------------------------------------------STSVEAMYS-VASQCLHEKKNKRPD-----IK-KVQQ----LLQ-----------
----LTFVQEIGSGQFGLV---HLGYW---L---------N-KD-KVAIKTIR-E--G-AM----SE--E-D-FI-E-------------------------EAEVMMKL--S------HPK-----LVQLYGVCL--E--------QAPIC--LVFEFMEHG--CLSDYLR-----TQ-----------------------R-GLF---AAETLLGMCLDVCEGMAYLEE--A---C---VIHRDLAARNCLVG--ENQ-VI-------------------KVSDFGMTRFV-------L--DDQY--------------TSSTGTKFPVKWASPEVFS------FSR--YSSKSDVWSFGVLMWEVFSEGKIP---------------YE-NR--SNSEVVEDI-STGFRLYKPRLAS---------------------------------------------------------------THVYQ-IMNHCWKERPEDRPA-----FS-RLLRQL----------------
----LKFLQQLGKGNFGSV---EMCRY---DP---LQDN-T-GE-VVAVKKLQ-H--S-TE-----EHLR-D-FE-R-------------------------EIEILKSL--Q------HDN-----IVKYKGVCYSAG--------RRNLK--LIMEYLPYG--SLRDYLQ-----KH-----------------------K-ERI---DHIKLLQYTSQICKGMEYLGT--K---R---YIHRDLATRNILVE--NEN-RV-------------------KIGDFGLTKVL---PQ--D--KEYY--------------KVKEPGESPIFWYAPESLT------ESK--FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG-QM--IVFHLIELL-KNNGRLPRPDGCP---------------------------------------------------------------DEIYM-IMTECWNNNVNQRPS-----FR-DLA----LRV------------
---L-KYISQLGKGNFGSV---ELCRY---DP---LGDN-T-GA-LVAVKQLQ-H--S-GP----DQ-QR-D-FQ-R-------------------------EIQILKAL--H------SDF-----IVKYRGVSYGPG--------RQSLR--LVMEYLPSG--CLRDFLQ-----RH-----------------------R-ARL---DASRLLLYSSQICKGMEYLGS--R---R---CVHRDLAARNILVE--SEA-HV-------------------KIADFGLAKLL---PL--D--KDYY--------------VVREPGQSPIFWYAPESLS------DNI--FSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCER-DV-PALCRLLELL-EEGQRLPAPPACP---------------------------------------------------------------AEVHE-LMKLCWAPSPQDRPS-----FS-ALGP---QL-------------
----LKLVERLGAGQFGEV---WMGYY---N---------G-HT-KVAVKSLK-Q--G-SM----SP--D-A-FL-A-------------------------EANLMKQL--Q------HQR-----LVRLYAVVT-----------QEPIY--IITEYMENG--SLVDFLK-----TP----------------------SG-IKL---TINKLLDMAAQIAEGMAFIEE--R---N---YIHRDLRAANILVS--DTL-SC-------------------KIADFGLARLI-------E--DNEY--------------TAREGAKFPIKWTAPEAIN------YGT--FTIKSDVWSFGILLTEIVTHGRIP---------------YP-GM--TNPEVIQNL-ERGYRMVRPDNCP---------------------------------------------------------------EELYQ-LMRLCWKERPEDRPT-----FD-YLRSV--L--------------
----IKLVKRLGAGQFGEV---WMGYY---N---------N-ST-KVAVKTLK-P--G-TM----SV--Q-A-FL-E-------------------------EANLMKTL--Q------HDK-----LVRLYAVVT--R--------EEPIY--IITEYMAKG--SLLDFLK-----SD----------------------EG-GKV---LLPKLIDFSAQIAEGMAYIER--K---N---YIHRDLRAANVLVS--ESL-MC-------------------KIADFGLARVI-------E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGC--FTIKSDVWSFGILLYEIVTYGKIP---------------YP-GR--TNADVMTAL-SQGYRMPRVENCP---------------------------------------------------------------DELYD-IMKMCWKEKAEERPT-----FD-YLQSV--L--------------
----FEKISELGAGNGGVV---FKVSH---K-------P-S-GL--VMARKLIHL--E-IKP---AI--R-N-QIIR-------------------------ELQVLHEC--N------SPY-----IVGFYGAFY--S--------DGEIS--ICMEHMDGG--SLDQVLK----KAG--------------------------RI---PEQILGKVSIAVIKGLTYLRE-KH---K---IMHRDVKPSNILVN--SRG-EI-------------------KLCDFGVSG---------QLIDSMA--------------NS---FVGTRSYMSPERLQ------GTH--YSVQSDIWSMGLSLVEMAV-GRYP---------------IP-PP--DAKELELMF-GCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE--------------------LLDYIVNEPPPKLPSGVFSLEFQD-FVNKCLIKNPAERAD-----LK-QLMVHAFI--------------
----IEVEEVVGRGAFGVV---CKAKW---R-----------AK-DVAIKQIE-------S----ESERK-A-FI-V-------------------------ELRQLSRV--N------HPN-----IVKLYGACL------------NPVC--LVMEYAEGG--SLYNVLH-----GA----------------------EPLPYY---TAAHAMSWCLQCSQGVAYLHS--M---QPKALIHRDLKPPNLLLV--AGGTVL-------------------KICDFGTACDI-------------Q--------------THMTNNKGSAAWMAPEVFE------GSN--YSEKCDVFSWGIILWEVITR-RKP---------------FD-EIGGPAFRIMWAV-HNGTRPPLIKNLP---------------------------------------------------------------KPIES-LMTRCWSKDPSQRPS-----ME-EIVKI--M--------------
----YQNLKPIGSGAQGIV---CAAYD---A-------V-L-DR-NVAIKKLSRP--F-QNQ---TH--A-K-RAYR-------------------------ELVLMKCV--N------HKN-----IISLLNVFT--PQKT--LEEFQDVY--LVMELMDA---NLCQVIQ------M--------------------------EL---DHERMSYLLYQMLCGIKHLHS--A---G---IIHRDLKPSNIVVK--SDC-TL-------------------KILDFGLART--------AGTSFMM--------------TP---YVVTRYYRAPEVIL------GMG--YKENVDIWSVGCIMGEMVR-HKIL---------------FP-GR--DYIDQWNKV-IEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK----------------------LFPDSLFPADSEHNKLKASQARD-LLSKMLVIDPAKRIS-----VD-DALQHPYI--------------
----YQNLKPIGSGAQGIV---CAAYD---A-------I-L-ER-NVAIKKLSRP--F-QNQ---TH--A-K-RAYR-------------------------ELVLMKCV--N------HKN-----IIGLLNVFT--PQKS--LEEFQDVY--IVMELMDA---NLCQVIQ------M--------------------------EL---DHERMSYLLYQMLCGIKHLHS--A---G---IIHRDLKPSNIVVK--SDC-TL-------------------KILDFGLART--------AGTSFMM--------------TP---YVVTRYYRAPEVIL------GMG--YKENVDLWSVGCIMGEMVC-HKIL---------------FP-GR--DYIDQWNKV-IEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK----------------------LFPDVLFPADSEHNKLKASQARD-LLSKMLVIDASKRIS-----VD-EALQHPYI--------------
----YQQLKPIGSGAQGIV---CAAFD---T-------V-L-GI-NVAVKKLSRP--F-QNQ---TH--A-K-RAYR-------------------------ELVLLKCV--N------HKN-----IISLLNVFT--PQKT--LEEFQDVY--LVMELMDA---NLCQVIH------M--------------------------EL---DHERMSYLLYQMLCGIKHLHS--A---G---IIHRDLKPSNIVVK--SDC-TL-------------------KILDFGLART--------ACTNFMM--------------TP---YVVTRYYRAPEVIL------GMG--YKENVDIWSVGCIMGELVK-GCVI---------------FQ-GT--DHIDQWNKV-IEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEE----------------------LFPDWIFPSESERDKIKTSQARD-LLSKMLVIDPDKRIS-----VD-EALRHPYI--------------
----YRLLRTIGKGNFAKV---KLARH---I-------L-T-GR-EVAIKIIDKT--Q-LNP---SS--L-Q-KLFR-------------------------EVRIMKGL--N------HPN-----IVKLFEVIE--T--------EKTLY--LVMEYASAG--EVFDYLV----SHG--------------------------RM---KEKEARAKFRQIVSAVHYCHQ--K---N---IVHRDLKAENLLLD--AEA-NI-------------------KIADFGFSNE--------FTLGSKL--------------DT---FCGSPPYAAPELFQ-----GKKY--DGPEVDIWSLGVILYTLVS-GSLP---------------FD-GH-----NLKELR-ERVLRGKYRVPFYMS-------------------------------------------------------------TDCES-ILRRFLVLNPAKRCT-----LE-QIMKDKWI--------------
----VHFNEVIGRGHFGCV---YHGTL---L----DNDG-K-KI-HCAVKSLN-R--I-TD----IGEVS-Q-FL-T-------------------------EGIIMKDF--S------HPN-----VLSLLGICL-RS--------EGSPL--VVLPYMKHG--DLRNFIR-----NE-----------------------T-HNP---TVKDLIGFGLQVAKGMKYLAS--K---K---FVHRDLAARNCMLD--EKF-TV-------------------KVADFGLARDM----Y--D--KEYYS------------VHNKTGAKLPVKWMALESLQ------TQK--FTTKSDVWSFGVLLWELMTRGAPP---------------YP-DV--NTFDITVYL-LQGRRLLQPEYCP---------------------------------------------------------------DPLYE-VMLKCWHPKAEMRPS-----FS-ELVSR--I--------------
---I-EYVRDIGEGAFGRV---FQARA---PG--LLPYE-P-FT-MVAVKMLK-E--E-AS----ADMQA-D-FQ-R-------------------------EAALMAEF--D------NPN-----IVKLLGVCA--V--------GKPMC--LLFEYMAYG--DLNEFLR-----SMSPHTVCSLSHSDLSMRAQVSSPGP-PPL---SCAEQLCIARQVAAGMAYLSE--R---K---FVHRDLATRNCLVG--ENM-VV-------------------KIADFGLSRNI----Y--S--ADYY--------------KANENDAIPIRWMPPESIF------YNR--YTTESDVWAYGVVLWEIFSYGLQP---------------YY-GM--AHEEVIYYV-RDGNILSCPENCP---------------------------------------------------------------VELYN-LMRLCWSKLPADRPS-----FT-SIHRIL----------------
---I-VLKRELGEGAFGKV---FLAEC---YN--LCPEQ-D-KI-LVAVKTLK-D--A-SD----NA-RK-D-FH-R-------------------------EAELLTNL--Q------HEH-----IVKFYGVCV--E--------GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAV-----------LMAEGNPP-TEL---TQSQMLHIAQQIAAGMVYLAS--Q---H---FVHRDLATRNCLVG--ENL-LV-------------------KIGDFGMSRDV----Y--S--TDYY--------------RVGGHTMLPIRWMPPESIM------YRK--FTTESDVWSLGVVLWEIFTYGKQP---------------WY-QL--SNNEVIECI-TQGRVLQRPRTCP---------------------------------------------------------------QEVYE-LMLGCWQREPHMRKN-----IK-GIHTL--L--------------
---I-VLKRELGEGAFGKV---FLAEC---YN--LSPTK-D-KM-LVAVKALK-D--P-TL----AA-RK-D-FQ-R-------------------------EAELLTNL--Q------HEH-----IVKFYGVCG--D--------GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAMIL--------VDGQPRQAK-GEL---GLSQMLHIASQIASGMVYLAS--Q---H---FVHRDLATRNCLVG--ANL-LV-------------------KIGDFGMSRDV----Y--S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM------YRK--FTTESDVWSFGVILWEIFTYGKQP---------------WF-QL--SNTEVIECI-TQGRVLERPRVCP---------------------------------------------------------------KEVYD-VMLGCWQREPQQRLN-----IK-EIYKIL----------------
----YELQETLGKGTYGKV---KRATE---R-------F-S-GR-VVAIKSIRKD--K-IKD---EQ--D-M-VHIR------------------------REIEIMSSL--N------HPH-----IISIYEVFE--N--------KDKIV--IIMEYASKG--ELYDYIS----ERR--------------------------RL---SERETRHFFRQIVSAVHYCHK--N---G---VVHRDLKLENILLD--DNC-NI-------------------KIADFGLSNL--------YQKDKFL--------------QT---FCGSPLYASPEIVN-----GRPY--RGPEVDSWALGVLLYTLVY-GTMP---------------FD-GF-----DHKNLI-RQISSGEYREPTQP--------------------------------------------------------------SDARG-LIRWMLMVNPDRRAT-----IE-DIANHWW-V-------------
---F-KFGKILGEGSFSTV---VLARE---L-------A-T-SR-EYAIKILEKR--H-IIK---EN--K-VPYVTR-------------------------ERDVMSRL--D------HPF-----FVKLYFTFQ--D--------DEKLY--FGLSYAKNG--ELLKYIR----KIG--------------------------SF---DETCTRFYTAEIVSALEYLHG--K---G---IIHRDLKPENILLN--EDM-HI-------------------QITDFGTAKVLS-----PESKQARA--------------NS---FVGTAQYVSPELLT------EKS--ACKSSDLWALGCIIYQLVA-GLPP---------------FR-AG-----NEYLIF-QKIIKLEYDFPEKFF-------------------------------------------------------------PKARD-LVEKLLVLDATKRLG-----CE-EM------EGYGPLKAHPF---
----YEPKEILGRGVSSVV---RRCIH---K-------P-T-SQ-EYAVKVIDVT--G-GGS---FS--P-E-EVRELRE------------------ATLKEVDILRKV-SG------HPN-----IIQLKDTYE--T--------NTFFF--LVFDLMKRG--ELFDYLT----EKV--------------------------TL---SEKETRKIMRALLEVICTLHK--L---N---IVHRDLKPENILLD--DNM-NI-------------------KLTDFGFSCQ--------LEPGERL--------------RE---VCGTPSYLAPEIIECSMNEDHPG--YGKEVDMWSTGVIMYTLLA-GSPP---------------FW-HR-----KQMLML-RMIMSGNYQFGSPEWDDYS---------------------------------------------------------DTVKD-LVSRFLVVQPQNRYT-----AE-EALAHPFF--------------
-YDP---KDVIGRGVSSVV---RRCVH---R-------A-T-GH-EFAVKIMEVT--A-ERL---SP--E-Q-LEEVREA-------------------TRRETHILRQV-AG------HPH-----IITLIDSYE--S--------SSFMF--LVFDLMRKG--ELFDYLT----EKV--------------------------AL---SEKETRSIMRSLLEAVSFLHA--N---N---IVHRDLKPENILLD--DNM-QI-------------------RLSDFGFSCH--------LEPGEKL--------------RE---LCGTPGYLAPEILKCSMDETHPG--YGKEVDLWACGVILFTLLA-GSPP---------------FW-HR-----RQILML-RMIMEGQYQFSSPEWDDRS---------------------------------------------------------STVKD-LISRLLQVDPEARLT-----AE-QALQHPFF--------------
--YV--RGRFLGKGGFAKC---FEISD---A-------D-T-KE-VFAGKIVPKS--L-LLK---PH--Q-R-EKMS------------------------MEISIHRSL--A------HQH-----VVGFHGFFE--D--------NDFVF--VVLELCRRR--SLLELHK----RRK--------------------------AL---TEPEARYYLRQIVLGCQYLHR--N---R---VIHRDLKLGNLFLN--EDL-EV-------------------KIGDFGLATKV-------EYDGERK--------------KT---LCGTPNYIAPEVLS------KKG--HSFEVDVWSIGCIMYTLLV-GKPP---------------FE-TS-----CLKETY-LRIKKNEYSIPKHIN-------------------------------------------------------------PVAAS-LIQKMLQTDPTARPT-----IN-ELLNDEFF--------------
---F-NFLMVLGKGSFGKV---MLADR---K-------G-T-EE-LYAIKILKKD--V-VIQ---DD--D-V-ECTM------------------------VEKRVLALL-DK------PPF-----LTQLHSCFQ--T--------VDRLY--FVMEYVNGG--DLMYHIQ----QVG--------------------------KF---KEPQAVFYAAEISIGLFFLHK--R---G---IIYRDLKLDNVMLD--SEG-HI-------------------KIADFGMCKEH-------MMDGVTT--------------RT---FCGTPDYIAPEIIA------YQP--YGKSVDWWAYGVLLYEMLA-GQPP---------------FD-GE-----DEDELF-QSIMEHNVSYPKSLS-------------------------------------------------------------KEAVS-VCKGLMTKHPAKRLG-----C----------GPEGERDVREHAFF
--FI--FHKVLGKGSFGKV---LLGEL---K-------G-R-GE-YFAIKALKKD--V-VLI---DD--D-V-ECTM------------------------VEKRVLTLA-AE------NPF-----LTHLICTFQ--T--------KDHLF--FVMEFLNGG--DLMYHIQ----DKG--------------------------RF---ELYRATFYAAEIMCGLQFLHS--K---G---IIYRDLKLDNVLLD--RDG-HI-------------------KIADFGMCKEN-------IFGESRA--------------ST---FCGTPDYIAPEILQ------GLK--YTFSVDWWSFGVLLYEMLI-GQSP---------------FH-GD-----DEDELF-ESIRVDTPHYPRWIT-------------------------------------------------------------KESKD-ILEKLFEREPTKRLG----VTG-NIKIHPFF--------------
--FI--LHKMLGKGSFGKV---FLAEF---K-------K-T-NQ-FFAIKALKKD--V-VLM---DD--D-V-ECTM------------------------VEKRVLSLA-WE------HPF-----LTHMFCTFQ--T--------KENLF--FVMEYLNGG--DLMYHIQ----SCH--------------------------KF---DLSRATFYAAEIILGLQFLHS--K---G---IVYRDLKLDNILLD--KDG-HI-------------------KIADFGMCKEN-------MLGDAKT--------------NT---FCGTPDYIAPEILL------GQK--YNHSVDWWSFGVLLYEMLI-GQSP---------------FH-GQ-----DEEELF-HSIRMDNPFYPRWLE-------------------------------------------------------------KEAKD-LLVKLFVREPEKRLG-----VRGDIRQHPLF--------------
---F-TLCRKLGSGYFGEV---FEGLW---K---------D-RV-QVAIKVIS-R--D-NL----LH-QQ-M-LQ-S-------------------------EIQAMKKL--R------HKH-----ILALYAVVS--V--------GDPVY--IITELMAKG--SLLELLR-----DS----------------------DE-KVL---PVSELLDIAWQVAEGMCYLES--Q---N---YIHRDLAARNILVG--ENT-LC-------------------KVGDFGLARLI----------KEDV--------------YLSHDHNIPYKWTAPEALS------RGH--YSTKSDVWSFGILLHEMFSRGQVP---------------YP-GM--SNHEAFLRV-DAGYRMPCPLECP---------------------------------------------------------------PSVHK-LMLTCWCRDPEQRPC-----FK-ALRERL----------------
----FELLKVLGQGSFGKVFLVRKVTR---P-------D-S-GH-LYAMKVLKKA--T-LKV---RD--R-V-RTKM-------------------------ERDILADV--N------HPF-----VVKLHYAFQ--T--------EGKLY--LILDFLRGG--DLFTRLS----KEV--------------------------MF---TEEDVKFYLAELALGLDHLHS--L---G---IIYRDLKPENILLD--EEG-HI-------------------KLTDFGLSKEA-------IDHEKKA--------------YS---FCGTVEYMAPEVVN------RQG--HSHSADWWSYGVLMFEMLT-GSLP---------------FQ-GK-----DRKETM-TLILKAKLGMPQFLS-------------------------------------------------------------TEAQS-LLRALFKRNPANRLGSGPDGAE-EIKRHV--FY------------
----FELLRVLGKGGYGKV---FQVRKVTGA-------N-T-GK-IFAMKVLKKA--M-IVR---NA--K-D-TAHTK-----------------------AERNILEEV--K------HPF-----IVDLIYAFQ--T--------GGKLY--LILEYLSGG--ELFMQLE----REG--------------------------IF---MEDTACFYLAEISMALGHLHQ--K---G---IIYRDLKPENIMLN--HQG-HV-------------------KLTDFGLCKES-------IHDGTVT--------------HT---FCGTIEYMAPEILM------RSG--HNRAVDWWSLGALMYDMLT-GAPP---------------FT-GE-----NRKKTI-DKILKCKLNLPPYLT-------------------------------------------------------------QEARD-LLKKLLKRNAASRLGAGPGDAG-EVQAHPFF--------------
----YDIEGTLGKGNFAVV---KLGRH---R-------I-T-KT-EVAIKIIDKS--Q-LDA---VN--L-E-KIYR-------------------------EVQIMKML--D------HPH-----IIKLYQVME--T--------KSMLY--LVTEYAKNG--EIFDYLA----NHG--------------------------RL---NESEARRKFWQILSAVDYCHG--R---K---IVHRDLKAENLLLD--NNM-NI-------------------KIADFGFGNF--------FKSGELL--------------AT---WCGSPPYAAPEVFE-----GQQY--EGPQLDIWSMGVVLYVLVC-GALP---------------FD-GP-----TLPILR-QRVLEGRFRIPYFMS-------------------------------------------------------------EDCEH-LIRRMLVLDPSKRLT-----IA-QIKEHKWM--------------
---L-RLEVKLGQGCFGEV---WMGTW---N---------G-TT-RVAIKTLK-P--G-TM----SP--E-A-FL-Q-------------------------EAQVMKKL--R------HEK-----LVQLYAVVS-----------EEPIY--IVTEYMSKG--SLLDFLK-----GE----------------------TG-KYL---RLPQLVDMAAQIASGMAYVER--M---N---YVHRDLRAANILVG--ENL-VC-------------------KVADFGLARLI-------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR--FTIKSDVWSFGILLTELTTKGRVP---------------YP-GM--VNREVLDQV-ERGYRMPCPPECP---------------------------------------------------------------ESLHD-LMCQCWRKEPEERPT-----FE-YLQAF--L--------------
----WEIVGELGDGAFGKV---YKAKN---K-------E-T-GA-LAAAKVIETK--S-EEE---LE--D-Y-I--V-------------------------EIEILATC--D------HPY-----IVKLLGAYY--H--------DGKLW--IMIEFCPGG--AVDAIML---ELDR--------------------------GL---TEPQIQVVCRQMLEALNFLHS--K---R---IIHRDLKAGNVLMT--LEG-DI-------------------RLADFGVSAKN-------LKTLQKR--------------DS---FIGTPYWMAPEVVMCE-TMKDTP--YDYKADIWSLGITLIEMAQ-IEPP---------------HH-EL--NPMRVLLKI-AKSDPPTLLTPSKWS-------------------------------------------------------------VEFRD-FLKIALDKNPETRPS-----AA-QLLEHPFV--------------
-LCP---GRELGRGKFAVV---RKCIK---K-------D-S-GK-EFAAKFMRKR--R-KGQ---DC--R-M-EIIH-------------------------EIAVLELA-QD------NPW-----VINLHEVYE--T--------ASEMI--LVLEYAAGG--EIFDQCVA--DREE--------------------------AF---KEKDVQRLMRQILEGVHFLHT--R---D---VVHLDLKPQNILLT--SES-PLG----------------DIKIVDFGLSRI--------LKNSEEL--------------RE---IMGTPEYVAPEILS------YDP--ISMATDMWSIGVLTYVMLT-GISP---------------FL-GN-----DKQETF-LNISQMNLSYSEEEFDVLS---------------------------------------------------------ESAVD-FIRTLLVKKPEDRAT-----AE-ECLKHPWL--------------
----YTFGRILGKGSFGIV---IEATD---K-------E-T-ET-KWAIKKVNKE--K-AGS---SA--V-K-LLER-------------------------EVNILKSV--K------HEH-----IIHLEQVFE--T--------PKKMY--LVMELCEDG--ELKEILD----RKG--------------------------HF---SENETRWIIQSLASAIAYLHN--N---D---IVHRDLKLENIMVK--SSL-IDDNNE----------INLNIKVTDFGLAVKK------QSRSEAML--------------QA---TCGTPIYMAPEVIS------AHD--YSQQCDIWSIGVVMYMLLR-GEPP---------------FL-AS-----SEEKLF-ELIRKGELHFENAVWNSIS---------------------------------------------------------DCAKS-VLKQLMKVDPAHRIT-----AK-ELLDNQWL--------------
---L-RLLEKLGDGSFGVV---RRGEW---D----APSG-K-TV-SVAVKCLK-PDVL-SQ----PEAMD-D-FI-R-------------------------EVNAMHSL--D------HRN-----LIRLYGVVL-----------TPPMK--MVTELAPLG--SLLDRLR-----KH-----------------------Q-GHF---LLGTLSRYAVQVAEGMGYLES--K---R---FIHRDLAARNLLLA--TRD-LV-------------------KIGDFGLMRAL---PQ--N--DDHY--------------VMQEHRKVPFAWCAPESLK------TRT--FSHASDTWMFGVTLWEMFTYGQEP---------------WI-GL--NGSQILHKIDKEGERLPRPEDCP---------------------------------------------------------------QDIYN-VMVQCWAHKPEDRPT-----FV-ALRDF--L--------------
---L-RLEVKLGQGCFGEV---WMGTW---N---------G-TT-KVAIKTLK-P--G-TM----MP--E-A-FL-Q-------------------------EAQIMKKL--R------HDK-----LVPLYAVVS-----------EEPIY--IVTEFMSKG--SLLDFLK-----EG----------------------DG-KYL---KLPQLVDMAAQIADGMAYIER--M---N---YIHRDLRAANILVG--ENL-VC-------------------KIADFGLARLI-------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR--FTIKSDVWSFGILQTELVTKGRVP---------------YP-GM--VNREVLEQV-ERGYRMPCPQGCP---------------------------------------------------------------ESLHE-LMNLCWKKDPDERPT-----FE-YIQSFL----------------
---L-QFFENCGGGSFGSV---YRAKW---I-------S-Q-DK-EVAVKKL-----------------L-K-IE-K-------------------------EAEILSVL--S------HRN-----IIQFYGVIL--E--------PPNYG--IVTEYASLG--SLYDYIN-----SN----------------------RS-EEM---DMDHIMTWATDVAKGMHYLHM--EAPVK---VIHRDLKSRNVVIA--ADG-VL-------------------KICDFGASRFH------------NH--------------TTHMSLVGTFPWMAPEVIQ------SLP--VSETCDTYSYGVVLWEMLTR-EVP---------------FK-GL--EGLQVAWLVVEKNERLTIPSSCP---------------------------------------------------------------RSFAE-LLHQCWEADAKKRPS-----FK-QIISIL----------------
LIAD----IELGCGNFGSV---RQGVY---R-----MRK-K-QI-DVAIKVLK-Q--G-TE----KADTE-E-MM-R-------------------------EAQIMHQL--D------NPY-----IVRLIGVCQ-----------AEALM--LVMEMAGGG--PLHKFLV-----GK-----------------------R-EEI---PVSNVAELLHQVSMGMKYLEE--K---N---FVHRDLAARNVLLV--NRH-YA-------------------KISDFGLSKAL---GA--D--DSYY--------------TARSAGKWPLKWYAPECIN------FRK--FSSRSDVWSYGVTMWEALSYGQKP---------------YK-KM--KGPEVMAFI-EQGKRMECPPECP---------------------------------------------------------------PELYA-LMSDCWIYKWEDRPD-----FL-TVEQR--M--------------
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