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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK3 203
Other AURKA 133
Other AURKB 77
TK CSK 195
TK EPHB4 615
TK FGFR1 478
TK IGF1R 999
Other PLK1 53
TK PTK2 422
TK RET 724
YL--KGRLLGKGGFARCYEATDT-------ETGSAYAVKVIPQSR-VAKPH--QREKILNEIELHRDL-QHRHIVRFSHHFE-DADNIYIFLELCSRKSLAHIWKARH-------------------------TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARL----EPPEQRKKT---ICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLC-GSPPFETA---DLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFF
--FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKAGV--EHQLRR-EVEIQSHL-RHPNILRLYGYFH-DATRVYLILEYAPLGTVYRELQKLS-------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI
--FEIGRPLGKGKFGNVYLAREK-------KSHFIVALKVLFKSQ-IEKEG--VEHQLRREIEIQAHL-HHPNILRLYNYFY-DRRRIYLILEYAPRGELYKELQKSC-------------------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSV------HAPSLRRKT---MCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWV
--LKLLQTIGKGEFGDVMLGDYR---------GNKVAVKCIK-ND-AT-AQ---AFL-A-EASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR-SR----------------------GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA----------SSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP--PAVYEVMKNCWHLDAAMRPSFLQLREQL--
-V-KIEEVIGAGEFGEVCRGRLK----APGKKESCVAIKTLK-GG-YT-ERQRREFL-S-EASIMGQF-EHPNIIRLEGVVT-NSMPVMILTEFMENGALDSFLR-LN-----------------------DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSS--DPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCP--TSLHQLMLDCWQKDRNARPRFPQVVSAL--
-L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SD-AT-EKDLSDLI-S-EMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNLREYLQ-ARRPPGLEY--------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI---HH--IDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT--NELYMMMRDCWHAVPSQRPTFKQLVEDL--
--ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-EA-AS-MRERIEFL-N-EASVMKEF-NCHHVVRLLGVVS-QGQPTLVIMELMTRGDLKSYLR-SLRPEM--------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI---YE--TDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCP--DMLFELMRMCWQYNPKMRPSFLEIISS--I
YV--RGRFLGKGGFAKCFEISDA-------DTKEVFAGKIVPKSL-LLKPH--QREKMSMEISIHRSL-AHQHVVGFHGFFE-DNDFVFVVLELCRRRSLLELHKRRK-------------------------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV----EYDGERKKT---LCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLV-GKPPFETS---CLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFF
--IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-NC-TS-DSVREKFL-Q-EALTMRQF-DHPHIVKLIGVIT--ENPVWIIMELCTLGELRSFLQ-VR-----------------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM----E--DSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCP--PTLYSLMTKCWAYDPSRRPRFTELKAQL--
-L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-EN-AS-PSELRDLL-S-EFNVLKQV-NHPHVIKLYGACS-QDGPLLLIVEYAKYGSLRGFLR-ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV---YE--EDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCS--EEMYRLMLQCWKQEPDKRPVFADISKDL--
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