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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK3 203
TK ABL1 261
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
CAMK CHEK1 9
Other CHUK 15
CMGC CSNK2A1 39
TK FGFR1 478
CMGC GSK3A 119
CMGC GSK3B 56
TK HCK 241
TK LCK 245
TK LYN 247
CMGC MAPK1 13
CMGC MAPK11 24
CMGC MAPK14 24
CMGC MAPK8 26
AGC PDPK1 82
Other PLK1 53
Other PLK2 82
AGC PRKACA 44
TK PTK6 191
TK SRC 270
-YL--KGRLLGKGGFARCYEATDT-------ETGSAYAVKVIPQSRVAKPH--QR-EKILNEIELHRDL--QHRHIVRFSHHFED------ADNIY--IFLELCSRK--SLAHIWK----ARH-----------------TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT-ENMEL---KVGDFGLAARL----EPPEQRKKT---ICGTPNYVAPEVLL-RQGHGPEADVWSLGCVMYTLLC-GSPPFE-TA--------------DLKETYRCIKQVHYTLPASLS---------------------------------------LPARQLLAAILRASPRDRPS-----IDQILRHDFF-----------
---ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-EDTM-EV--EE-FL-K-EAAVMKEI--KHPNLVQLLGVCTR------EPPFY--IITEFMTYG--NLLDYLR-----EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLV---KVADFGLSRLM----T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYP-GI-----------DLSQVYELLEKDYRMERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F-----------
---YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLESEEEGV--PS-TAIR-EISLLKEL--RHPNIVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFH-GD-----------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF-----------
---FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDTETEGV--PS-TAIR-EISLLKEL--NHPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GD-----------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-----------
---YEKLEKIGEGTYGTVFKAKNR-------ETHEIVALKRVRLDDDDEGV--PS-SALR-EICLLKEL--KHKNIVRLHDVLHS------DKKLT--LVFEFCDQ---DLKKYFD---SCNG-----------------DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL---KLADFGLARAF----GIPVRCYSA---EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFP-GN-----------DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF-----------
--W-DLVQTLGEGAYGEVQLAVNR-------VTEEAVAVKIVDMKRAVDCP--EN-I-KK-EICINKML--NHENVVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE----PDI-----------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFR--YNNRERLLNK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELPWD-QP-------------SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y----------
--W-EMRERLGTGGFGNVCLYQHR-------ELDLKIAIKSCRLELSTKNR--ER--WCH-EIQIMKKL--NHANVVKACDVPEELN-ILIHDVPL--LAMEYCSGG--DLRKLLNK-PENCC-----------------GLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQ-DVGGKIIHKIIDLGYAKD-----VDQGSLCTS---FVGTLQYLAPELFE-NKPYTATVDYWSFGTMVFECIA-GYRPFL-HHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCS-----------------------------LVVEPMENWLQLMLNWDPQQRG----------------GPVDLTLKQ--
---YQLVRKLGRGKYSEVFEAINI-------TNNEKVVVKILKPVKKKKIK--R-------EIKILENL-RGGPNIITLADIVKDP----VSRTPA--LVFEHVNNT--DFKQLY-------Q-----------------TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL---RLIDWGLAEF-----YHPGQEYNV---RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGH-----------DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAMEHPYF-----------
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SDAT-EKDLSD-LI-S-EMEMMKMIG-KHKNIINLLGACTQ------DGPLY--VIVEYASKG--NLREYLQ-----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVM---KIADFGLARDI-H--H--IDYYKKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYP-GV-----------PVEELFKLLKEGHRMDKPSNCT-----------------------------------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL-------------
---YTDIKVIGNGSFGVVYQARLA-------ETRELVAIKKVLQDKRFKNR----------ELQIMRKL--DHCNIVRLRYFFYSSG--EKKDELYLNLVLEYVPETVYRVARHFT---KAKL-----------------TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVL---KLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFP-GD-----------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-----PLEACAHSFF-----------
---YTDTKVIGNGSFGVVYQAKLC-------DSGELVAIKKVLQDKRFKNR----------ELQIMRKL--DHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFP-GD-----------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF-----------
---LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-PGSM-SV--EA-FL-A-EANVMKTL--QHDKLVKLHAVVT-------KEPIY--IITEFMAKG--SLLDFLK-----SD--------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVS-ASLVC---KIADFGLARVI----E--DNEYTAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIPYP-GM-----------SNPEVIRALERGYRMPRPENCP-----------------------------------------EELYNIMMRCWKNRPEERPT-----FEYIQSV--L-----------
---LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QGSM-SP--DA-FL-A-EANLMKQL--QHQRLVRLYAVVT-------QEPIY--IITEYMENG--SLVDFLK-----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC---KIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYP-GM-----------TNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L-----------
---IKLVKRLGAGQFGEVWMGYYN--------NSTKVAVKTLK-PGTM-SV--QA-FL-E-EANLMKTL--QHDKLVRLYAVVTR------EEPIY--IITEYMAKG--SLLDFLK-----SD--------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVS-ESLMC---KIADFGLARVI----E--DNEYTAREGAKFPIKWTAPEAIN-FGCFTIKSDVWSFGILLYEIVTYGKIPYP-GR-----------TNADVMTALSQGYRMPRVENCP-----------------------------------------DELYDIMKMCWKEKAEERPT-----FDYLQSV--L-----------
---YTNLSYIGEGAYGMVCSAYDN-------VNKVRVAIKKISPFEHQTYC--QR-T-LR-EIKILLRF--RHENIIGINDIIRAPT-IEQMKDVY--IVQDLMET---DLYKLLK-----TQ-----------------HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDL---KICDFGLARVAD-PDHDHTGFLTE---YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFP-GK-----------HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIE-----VEQALAHPYL-----------
LQG---LRPVGSGAYGSVCSAYDA-------RLRQKVAVKKLSRPFQSLIH--AR-RTYR-ELRLLKHL--KHENVIGLLDVFTPATSIEDFSEVY--LVTTLMGA---DLNNIVK-----CQ-----------------ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCEL---RILDFGLAR-------QADEEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFP-GS-----------DYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-----------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS-----AAEALAHAYF-----------
---YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRPFQSIIH--AK-RTYR-ELRLLKHM--KHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-----------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR-------HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFP-GT-----------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF-----------
---YQNLKPIGSGAQGIVCAAYDA-------ILERNVAIKKLSRPFQNQTH--AK-RAYR-ELVLMKCV--NHKNIIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART-----AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVC-HKILFP-GR-----------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VDEALQHPYI-----------
--F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKILEKRHIIKEN--KVPYVTR-ERDVMSRL--DHPFFVKLYFTFQD------DEKLY--FGLSYAKNG--ELLKYIR----KIG-----------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI---QITDFGTAKVLS--PESKQARANS---FVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GLPPFR-AG--------------NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
-YV--RGRFLGKGGFAKCFEISDA-------DTKEVFAGKIVPKSLLLKPH--QR-EKMSMEISIHRSL--AHQHVVGFHGFFED------NDFVF--VVLELCRRR--SLLELHK----RRK-----------------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEV---KIGDFGLATKV----EYDGERKKT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPPFE-TS--------------CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPT-----INELLNDEFF-----------
--Y-CRGKVLGKGGFAKCYEMTDL-------TNNKVYAAKIIPHSRVAKPH--QR-EKIDKEIELHRIL--HHKHVVQFYHYFED------KENIY--ILLEYCSRR--SMAHILK----ARK-----------------VLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFIN-EAMEL---KVGDFGLAARL----EPLEHRRRT---ICGTPNYLSPEVLN-KQGHGCESDIWALGCVMYTMLL-GRPPFE-TT--------------NLKETYRCIREARYTMPSSLL---------------------------------------APAKHLIASMLSKNPEDRPS-----LDDIIRHDFF-----------
--F-ERIKTLGTGSFGRVMLVKHK-------ETGNHYAMKILDKQKVVKLK--QI-EHTLNEKRILQAV--NFPFLVKLEFSFKD------NSNLY--MVMEYVPGG--EMFSHLR----RIG-----------------RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYI---QVTDFGFAK-------RVKGRTWT---LCGTPEYLAPEIIL-SKGYNKAVDWWALGVLIYEMAA-GYPPFF-AD--------------QPIQIYEKIVSGKVRFPSHFS---------------------------------------SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF-----------
--F-TLCRKLGSGYFGEVFEGLWK--------DRVQVAIKVIS-RDNL-LH-QQM-LQ-S-EIQAMKKL--RHKHILALYAVVSV------GDPVY--IITELMAKG--SLLELLR-----DS--------------DEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVG-ENTLC---KVGDFGLARLI-------KEDVYLSHDHNIPYKWTAPEALS-RGHYSTKSDVWSFGILLHEMFSRGQVPYP-GM-----------SNHEAFLRVDAGYRMPCPLECP-----------------------------------------PSVHKLMLTCWCRDPEQRPC-----FKALRERL-------------
--L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PGTM-SP--EA-FL-Q-EAQVMKKL--RHEKLVQLYAVVS-------EEPIY--IVTEYMSKG--SLLDFLK-----GE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVC---KVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYP-GM-----------VNREVLDQVERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L-----------
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