|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PRKCD 203
Other AURKA 133
Other AURKB 77
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
CMGC GSK3B 56
CMGC MAPK10 64
CMGC MAPK11 24
CMGC MAPK8 26
AGC PRKCQ 380
-FI--FHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDV-VLI---DDDVECTMVEKRVLTLAAE---NPFLTHLICTFQT------KDHLF--FVMEFLNGG--DLMYHIQ----DKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLD-RDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQ-GLKYTFSVDWWSFGVLLYEMLIGQSPFHGD---DEDELFESIRVDTPHYPRWIT---------------------------------------KESKDILEKLFEREPTKRLGVTG-NIKIHPFF
---FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKA---GVEHQLRR-EVEIQSHL-R---HPNILRLYGYFHD------ATRVY--LILEYAPLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKIADFGWSV--HAPSSRRTTLCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLVGKPPFEAN---TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPM-LR-EVLEHPWI
---FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ-IEK---EGVEHQLRREIEIQAHL-H---HPNILRLYNYFYD------RRRIY--LILEYAPRG--ELYKELQ----KSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGELKIADFGWSV--HAPSLRRKTMCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLVGNPPFESA---SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSERLP-LA-QVSAHPWV
---YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEE---GVPSTAIR-EISLLKEL-R---HPNIVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-GK-MALNHPYF
---FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETE---GVPSTAIR-EISLLKEL-N---HPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-AK-AALAHPFF
--Y-EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPN-GGGGGGGLPISTVR-EVALLRRL-EAFEHPNVVRLMDVCATSR-TDREIKVT--LVFEHVDQ---DLRTYLDK--APPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARI-YSYQMALTPVVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRIS-AF-RALQHSYL
---YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-RFK---NR-------ELQIMRKL-D---HCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-PL-EACAHSFF
---YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF-QNQ---THAKRAYR-ELVLMKCV-N---HKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART-AGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-VD-DALQHPYI
LQG---LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPF-QSL---IHARRTYR-ELRLLKHL-K---HENVIGLLDVFTPATSIEDFSEVY--LVTTLMGA---DLNNIVK-----CQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLAR---QADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-----------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS-AA-EALAHAYF
---YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPF-QNQ---THAKRAYR-ELVLMKCV-N---HKNIIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ------MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART-AGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-VD-EALQHPYI
-FI--LHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDV-VLM---DDDVECTMVEKRVLSLAWE---HPFLTHMFCTFQT------KENLF--FVMEYLNGG--DLMYHIQ----SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLD-KDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILL-GQKYNHSVDWWSFGVLLYEMLIGQSPFHGQ---DEEELFHSIRMDNPFYPRWLE---------------------------------------KEAKDLLVKLFVREPEKRLG-VRGDIRQHPLF
|