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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PRKCZ 203
Other AURKA 133
Other AURKB 77
TKL BRAF 456
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK6 13
CAMK CHEK1 9
CMGC GSK3B 56
CMGC MAPK14 24
CAMK MKNK2 84
Other NEK2 8
TK NTRK3 538
AGC PDPK1 82
TK SRC 270
---F-DLIRVIGRGSYAKVLLVRLK-----KNDQ-IYAMKVVKKE-L-VHDDE--DI-DWVQTEKHVFEQASS---NPFLVGLHSCFQT------TSRLF--LVIEYVNGG--DLMFHMQ----RQR-----------------KLPEEHARFYAAEICIALNFLHER-----GIIYRDLKLDNVLLD-ADGHI---KLTDYGMCKEG--------LGPGDTT--------------ST---FCGTPNYIAPEILR-----GEE---YGFSVDWWALGVLMFEMMA-GRSPFDIITD--------NPDMNTEDYLFQVILE----KPIRIPRFLS----------------------------VKASHVLKGFLNKDPKERLGCRPQTGF---------SDIKSHAFF--
----FEIGRPLGKGKFGNVYLAREK-----QSKF-ILALKVLFKA-QLEKAGV--EH-QLRR-EVEIQSHL-R---HPNILRLYGYFHD------ATRVY--LILEYAPLG--TVYRELQ----KLS-----------------KFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLG-SAGEL---KIADFGWSV----------HAPSSRR--------------TT---LCGTLDYLPPEMIE-----GRM---HDEKVDLWSLGVLCYEFLV-GKPPFEAN---------------TYQETYKRISR----VEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPM------LREVLEHPWI-----------
----FEIGRPLGKGKFGNVYLAREK-----KSHF-IVALKVLFKS-Q-IEKEG--VE-HQLRREIEIQAHL-H---HPNILRLYNYFYD------RRRIY--LILEYAPRG--ELYKELQ----KSC-----------------TFDEQRTATIMEELADALMYCHGK-----KVIHRDIKPENLLLG-LKGEL---KIADFGWSV----------HAPSLRR--------------KT---MCGTLDYLPPEMIE-----GRM---HNEKVDLWCIGVLCYELLV-GNPPFESA---------------SHNETYRRIVK----VDLKFPASVP----------------------------MGAQDLISKLLRHNPSERLP------LAQVSAHPWV-----------
----ITVGQRIGSGSFGTVYKGKWH--------G-DVAVKMLN-VTA-PT-PQQLQA-FK-N-EVGVLRKT-R---HVNILLFMGYST-------KPQLA--IVTQWCEGS--SLYHHLH-----II---------------ETKFEMIKLIDIARQTAQGMDYLHAK-----SIIHRDLKSNNIFLH-EDLTV---KIGDFGLATVK---S----R--WSGS--------------HQFEQLSGSILWMAPEVIR-----MQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNI-N----------NRDQIIFMVGRGYLSPDLSKVRSNCP------------------------------KAMKRLMAECLKKKRDERPL------FPQILA---SI----------
----YTKIEKIGEGTYGVVYKGRHK-----TTGQ-VVAMKKIRLE-S-EEEGV--PS-TAIR-EISLLKEL-R---HPNIVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSR-----RVLHRDLKPQNLLID-DKGTI---KLADFGLARAF--------GIPIRVY--------------TH---EVVTLWYRSPEVLL----GSAR---YSTPVDIWSIGTIFAELAT-KKPLFHGD------------SEIDQLFRIFRALG----TPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRIS------GKMALNHPYF-----------
----FQKVEKIGEGTYGVVYKARNK-----LTGE-VVALKKIRLD-T-ETEGV--PS-TAIR-EISLLKEL-N---HPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF--------GVPVRTY--------------TH---EVVTLWYRAPEILL----GCKY---YSTAVDIWSLGCIFAEMVT-RRALFPGD------------SEIDQLFRIFRTLG----TPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS------AKAALAHPFF-----------
----YECVAEIGEGAYGKVFKARDL-----KNGGRFVALKRVRVQ-T-GEEGM--PL-STIR-EVAVLRHL-ETFEHPNVVRLFDVCTVSR-TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEP-----------------GVPTETIKDMMFQLLRGLDFLHSH-----RVVHRDLKPQNILVT-SSGQI---KLADFGLARI---------YSFQMAL--------------TS---VVVTLWYRAPEVLL-----QSS---YATPVDLWSVGCIFAEMFR-RKPLFRGS------------SDVDQLGKILDVIG----LPGEEDWPRDVALPRQAFHSKSAQ----PIEKFVTDIDELGKDLLLKCLTFNPAKRIS------AYSALSHPYF-----------
---W-DLVQTLGEGAYGEVQLAVNR-----VTEE-AVAVKIVDMK-R-AVDCP--EN-I-KK-EICINKML-N---HENVVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE----PDI-----------------GMPEPDAQRFFHQLMAGVVYLHGI-----GITHRDIKPENLLLD-ERDNL---KISDFGLATVFR------YNNRERLL--------------NK---MCGTLPYVAPELLK----RREF---HAEPVDVWSCGIVLTAMLA-GELPWDQP--------------SDSCQEYSDWKE----KKTYLNPWKKI--D------------------------SAPLALLHKILVENPSARIT------IPDIKKDRW-Y----------
----YTDTKVIGNGSFGVVYQAKLC-----DSGE-LVAIKKVLQD-K-RFKNR----------ELQIMRKL-D---HCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TLPVIYVKLYMYQLFRSLAYIHSF-----GICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ---------LVRGEPN--------------VS---YICSRYYRAPELIF----GATD---YTSSIDVWSAGCVLAELLL-GQPIFPGD------------SGVDQLVEIIKVLG----TPTREQIREMNPNYTEFKFPQIKAH--PWTKVFRPRTPPEAIALCSRLLEYTPTARLT------PLEACAHSFF-----------
----YQNLSPVGSGAYGSVCAAFDT-----KTGL-RVAVKKLSRP-F-QSIIH--AK-RTYR-ELRLLKHM-K---HENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-----------------KLTDDHVQFLIYQILRGLKYIHSA-----DIIHRDLKPSNLAVN-EDCEL---KILDFGLAR-----------HTDDEM--------------TG---YVATRWYRAPEIML----NWMH---YNQTVDIWSVGCIMAELLT-GRTLFPGT------------DHIDQLKLILRLVG----TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT------AAQALAHAYF-----------
QLQE----DVLGEGAHARVQTCINL-----ITSQ-EYAVKIIEKQ-P-GHIRS--R---VFR-EVEMLYQCQG---HRNVLELIEFFEE------EDRFY--LVFEKMRGG--SILSHIH----KRR-----------------HFNELEASVVVQDVASALDFLHNK-----GIAHRDLKPENILCE-HPNQVSPVKICDFDLGSGIKLN-GDCSPISTPEL--------------LT---PCGSAEYMAPEVVEAFSEEASI---YDKRCDLWSLGVILYILLS-GYPPFVGRCGSDCGWDRGEACPACQNMLFESIQE----GKYEFPDKDWAHIS------------------------CAAKDLISKLLVRDAKQRLS------AAQVLQHPWV-----------
----YEVLYTIGTGSYGRCQKIRRK-----SDGK-ILVWKELDYG-S-MTEAE--KQ-MLVS-EVNLLREL-K---HPNIVRYYDRIIDR----TNTTLY--IVMEYCEGG--DLASVITKGTKERQ-----------------YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNV---KLGDFGLARIL--------NHDTSFA--------------KT---FVGTPYYMSPEQMN-----RMS---YNEKSDIWSLGCLLYELCA-LMPPFTAF---------------SQKELAGKIRE----GKFRRIPYRY---S------------------------DELNEIITRMLNLKDYHRPS------VEEILENPL-I----------
---I-VLKRELGEGAFGKVFLAECYNLSPTKDKM-LVAVKALK-D-P-TL-AA-RKD-FQ-R-EAELLTNL-Q---HEHIVKFYGVCGD------GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQ-----HFVHRDLATRNCLVG-ANLLV---KIGDFGMSRDV---Y----S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----YRK---FTTESDVWSFGVILWEIFTYGKQPWFQL------------SNTEVIECITQGRV----LERPRVCP------------------------------KEVYDVMLGCWQREPQQRLN------IKEIYKIL-------------
---F-KFGKILGEGSFSTVVLAREL-----ATSR-EYAIKILEKR-H-IIKEN--KVPYVTR-ERDVMSRL-D---HPFFVKLYFTFQD------DEKLY--FGLSYAKNG--ELLKYIR----KIG-----------------SFDETCTRFYTAEIVSALEYLHGK-----GIIHRDLKPENILLN-EDMHI---QITDFGTAKVLS------PESKQARA--------------NS---FVGTAQYVSPELLT-----EKS---ACKSSDLWALGCIIYQLVA-GLPPFRAG---------------NEYLIFQKIIK----LEYDFPEKFF----------------------------PKARDLVEKLLVLDATKRLG------CEEM------EGYGPLKAHPF
---L-RLEVKLGQGCFGEVWMGTWN------GTT-RVAIKTLK-P-G-TM-SP--EA-FL-Q-EAQVMKKL-R---HEKLVQLYAVVS-------EEPIY--IVTEYMSKG--SLLDFLK-----GE--------------TGKYLRLPQLVDMAAQIASGMAYVERM-----NYVHRDLRAANILVG-ENLVC---KVADFGLARLI--------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILLTELTTKGRVPYPGM------------VNREVLDQVERGYR----MPCPPECP------------------------------ESLHDLMCQCWRKEPEERPT------FEYLQAF--L-----------
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