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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PRKCZ 203
AGC AKT1 150
TKL BRAF 456
Other CAMKK2 165
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
CMGC CDK6 13
CMGC CDK9 2.7.11.23
CAMK CHEK1 9
CMGC CSNK2A2 40
TK FYN 271
TK HCK 241
TK LYN 247
CMGC MAPK14 24
CAMK MARK4 59
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
CAMK PHKG1 20
CAMK PHKG2 24
AGC PKN1 615
AGC PRKCA 339
AGC PRKCB 342
AGC PRKCD 349
AGC PRKCQ 380
AGC RPS6KA1 62
CAMK SIK2 20
TK SRC 270
STE STK10 36
CAMK STK17A 61
CAMK STK33 116
--F-DLIRVIGRGSYAKV---LLVRLK-----KNDQ-IYAMKVVKKE-LVHD---DE--DIDWVQ------------------------TEKHVFEQASS---NPFLVGLHSCFQT--------TSRLFLVIEYVNGGDLMFHMQ---RQR-----------------KLPEEHARFYAAEICIALNFLHE-RGIIYRDLKLDNVLLD-ADGHI---------KLTDYGMCKEG-----LGPGDTT--------------ST---FCGTPNYIAPEILR------GEE----YGFSVDWWALGVLMFEMMA-GRSPFD-IITDNPDMNTEDYLFQVILE----KPIRIPRFLS----------------------------------VKASHVLKGFLNKDPKERLGCRPQTGF----------SDIKSHAFF-----
--F-EYLKLLGKGTFGKV---ILVKEK-----ATGR-YYAMKILKKE-VIVA---KD--EVAHTL------------------------TENRVLQNS-R---HPFLTALKYSFQT--------HDRLCFVMEYANGGELFFHLS---RER-----------------VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGHI---------KITDFGLCKEG-----IKDGATM--------------KT---FCGTPEYLAPEVLE------DND----YGRAVDWWGLGVVMYEMMC-GRLPFY-NQ-------DHEKLFELILM----EEIRFPRTLG----------------------------------PEAKSLLSGLLKKDPKQRLGGG-SEDAK-EIMQHRFF--------------
---ITVGQRIGSGSFGTV---YKGKWH--------G-DVAVKMLN-VTAPT----PQQLQAFK-N-------------------------EVGVLRKT-R---HVNILLFMGYST---------KPQLAIVTQWCEGSSLYHHLH----II---------------ETKFEMIKLIDIARQTAQGMDYLHA-KSIIHRDLKSNNIFLH-EDLTV---------KIGDFGLATVK--S--R--WSGS--------------HQFEQLSGSILWMAPEVIR------MQDK-NPYSFQSDVYAFGIVLYELMT-GQLPYS-NI-N--NRDQIIFMVGRGYLSPDLSKVRSNCP------------------------------------KAMKRLMAECLKKKRDERPL------FP-QILA---SI-------------
---YTLKDEIGKGSYGVV---KLAYNE-----NDNT-YYAMKVLSKK-KLIR---QA--GFPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL-D---HPNVVKLVEVLDDP------NEDHLYMVFELVNQGPVMEVPT----LK-----------------PLSEDQARFYFQDLIKGIEYLHY-QKIIHRDIKPSNLLVG-EDGHI---------KIADFGVSNEF-----KGSDALL--------------SN---TVGTPAFMAPESLS-----ETRKIF--SGKALDVWAMGVTLYCFVF-GQCPFM-DE-------RIMCLHSKIKS----QALEFPDQPDIA--------------------------------EDLKDLITRMLDKNPESRIV------VP-EIKLHPWV--------------
---YTKIEKIGEGTYGVV---YKGRHK-----TTGQ-VVAMKKIRLE-SEEE---GV--PSTAIR-------------------------EISLLKEL-R---HPNIVSLQDVLMQ--------DSRLYLIFEFLSM-DLKKYLDSIPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHS-RRVLHRDLKPQNLLID-DKGTI---------KLADFGLARAF-----GIPIRVY--------------TH---EVVTLWYRSPEVLL-----GSAR----YSTPVDIWSIGTIFAELAT-KKPLFH-GD----SEIDQLFRIFRALG----TPNNEVWPEVESLQDYKNTFPKWKP--------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS------GK-MALNHPYF--------------
---FQKVEKIGEGTYGVV---YKARNK-----LTGE-VVALKKIRLD-TETE---GV--PSTAIR-------------------------EISLLKEL-N---HPNIVKLLDVIHT--------ENKLYLVFEFLHQ-DLKKFMDA-SALT-----------------GIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLIN-TEGAI---------KLADFGLARAF-----GVPVRTY--------------TH---EVVTLWYRAPEILL-----GCKY----YSTAVDIWSLGCIFAEMVT-RRALFP-GD----SEIDQLFRIFRTLG----TPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS------AK-AALAHPFF--------------
--Y-EPVAEIGVGAYGTV---YKARDP-----HSGH-FVALKSVRVP-NGGGGGGGL--PISTVR-------------------------EVALLRRL-EAFEHPNVVRLMDVCATSR---TDREIKVTLVFEHVDQ-DLRTYLDK-APPP-----------------GLPAETIKDLMRQFLRGLDFLHA-NCIVHRDLKPENILVT-SGGTV---------KLADFGLARI------YSYQMAL--------------TP---VVVTLWYRAPEVLL------QST----YATPVDMWSVGCIFAEMFR-RKPLFC-GN----SEADQLGKIFDLIG----LPPEDDWPRDVSLPRGAFPPRGPR----------PVQSVVPEMEESGAQLLLEMLTFNPHKRIS------AF-RALQHSYL--------------
---YECVAEIGEGAYGKV---FKARDL-----KNGGRFVALKRVRVQ-TGEE---GM--PLSTIR-------------------------EVAVLRHL-ETFEHPNVVRLFDVCTVSR---TDRETKLTLVFEHVDQ-DLTTYLDK-VPEP-----------------GVPTETIKDMMFQLLRGLDFLHS-HRVVHRDLKPQNILVT-SSGQI---------KLADFGLARI------YSFQMAL--------------TS---VVVTLWYRAPEVLL------QSS----YATPVDLWSVGCIFAEMFR-RKPLFR-GS----SDVDQLGKILDVIG----LPGEEDWPRDVALPRQAFHSKSAQ----------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS------AY-SALSHPYF--------------
---YEKLAKIGQGTFGEV---FKARHR-----KTGQ-KVALKKVLME-NEKE---GF--PITALR-------------------------EIKILQLL-K---HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLS--NVLV-----------------KFTLSEIKRVMQMLLNGLYYIHR-NKILHRDMKAANVLIT-RDGVL---------KLADFGLARAFSL-AKNSQPNRY--------------TN---RVVTLWYRPPELLL-----GERD----YGPPIDLWGAGCIMAEMWT-RSPIMQ-GN----TEQHQLALISQLCG----SITPEVWPNVDNYELYEKLELVKGQK-----RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID------SD-DALNHDFF--------------
--W-DLVQTLGEGAYGEV---QLAVNR-----VTEE-AVAVKIVDMK-RAVD---CP--ENI-KK-------------------------EICINKML-N---HENVVKFYGHRRE--------GNIQYLFLEYCSGGELFDRIE---PDI-----------------GMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLLLD-ERDNL---------KISDFGLATVFR---YNNRERLL--------------NK---MCGTLPYVAPELLK-----RREF----HAEPVDVWSCGIVLTAMLA-GELPWD-QP------SDSCQEYSDWKE----KKTYLNPWKKI--D------------------------------SAPLALLHKILVENPSARIT------IP-DIKKDRW-Y-------------
---YQLVRKLGRGKYSEV---FEAINI-----TNNE-RVVVKILKPV-KKKK---IK--R------------------------------EVKILENLRG---GTNIIKLIDTVKDP------VSKTPALVFEYINNTDFKQLY------Q-----------------ILTDFDIRFYMYELLKALDYCHS-KGIMHRDVKPHNVMIDHQQKKL---------RLIDWGLAEF------YHPAQEY--------------NV---RVASRYFKGPELLV-----DYQM----YDYSLDMWSLGCMLASMIF-RREPFFHGQ----DNYDQLVRIAKVLG----TEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT------AK-EAMEHPYF--------------
---LQLIKRLGNGQFGEV---WMGTWN------GNT-KVAIKTLK-P-GTM----SP--ESFL-E-------------------------EAQIMKKL-K---HDKLVQLYAVVS---------EEPIYIVTEYMNKGSLLDFLK----DG--------------EGRALKLPNLVDMAAQVAAGMAYIER-MNYIHRDLRSANILVG-NGLIC---------KIADFGLARLI-----E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR----FTIKSDVWSFGILLTELVTKGRVPYP-GM----NNREVLEQVERGYR----MPCPQDCP------------------------------------ISLHELMIHCWKKDPEERPT------FE-YLQSFL----------------
---LKLEKKLGAGQFGEV---WMATYN------KHT-KVAVKTMK-P-GSM----SV--EAFL-A-------------------------EANVMKTL-Q---HDKLVKLHAVVT---------KEPIYIITEFMAKGSLLDFLK----SD--------------EGSKQPLPKLIDFSAQIAEGMAFIEQ-RNYIHRDLRAANILVS-ASLVC---------KIADFGLARVI-----E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGS----FTIKSDVWSFGILLMEIVTYGRIPYP-GM----SNPEVIRALERGYR----MPRPENCP------------------------------------EELYNIMMRCWKNRPEERPT------FE-YIQSV--L--------------
---IKLVKRLGAGQFGEV---WMGYYN------NST-KVAVKTLK-P-GTM----SV--QAFL-E-------------------------EANLMKTL-Q---HDKLVRLYAVVTR--------EEPIYIITEYMAKGSLLDFLK----SD--------------EGGKVLLPKLIDFSAQIAEGMAYIER-KNYIHRDLRAANVLVS-ESLMC---------KIADFGLARVI-----E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGC----FTIKSDVWSFGILLYEIVTYGKIPYP-GR----TNADVMTALSQGYR----MPRVENCP------------------------------------DELYDIMKMCWKEKAEERPT------FD-YLQSV--L--------------
---YQNLSPVGSGAYGSV---CAAFDT-----KTGL-RVAVKKLSRP-FQSI---IH--AKRTYR-------------------------ELRLLKHM-K---HENVIGLLDVFTPARS--LEEFNDVYLVTHLMGA-DLNNIVK----CQ-----------------KLTDDHVQFLIYQILRGLKYIHS-ADIIHRDLKPSNLAVN-EDCEL---------KILDFGLAR--------HTDDEM--------------TG---YVATRWYRAPEIML-----NWMH----YNQTVDIWSVGCIMAELLT-GRTLFP-GT----DHIDQLKLILRLVG----TPGAELLKKISSESARNYIQSLTQMP------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT------AA-QALAHAYF--------------
---YRLLRTIGKGNFAKV---KLARHI-----LTGR-EVAIKIIDKT-QLNP---SS--LQKLFR-------------------------EVRIMKGL-N---HPNIVKLFEVIET--------EKTLYLVMEYASAGEVFDYLV---SHG-----------------RMKEKEARAKFRQIVSAVHYCHQ-KNIVHRDLKAENLLLD-AEANI---------KIADFGFSNE------FTLGSKL--------------DT---FCGSPPYAAPELFQ-----GKKY----DGPEVDIWSLGVILYTLVS-GSLPFD-GH-------NLKELRERVLR----GKYRVPFYMS----------------------------------TDCESILRRFLVLNPAKRCT------LE-QIMKDKWI--------------
--I-VLKRELGEGAFGKV---FLAECYNLCPEQDKI-LVAVKTLK-D-ASD----NA-RKDFH-R-------------------------EAELLTNL-Q---HEHIVKFYGVCVE--------GDPLIMVFEYMKHGDLNKFLR----AHGPDAV---LMAEGNPPTELTQSQMLHIAQQIAAGMVYLAS-QHFVHRDLATRNCLVG-ENLLV---------KIGDFGMSRDV--Y--S--TDYY--------------RVGGHTMLPIRWMPPESIM------YRK----FTTESDVWSLGVVLWEIFTYGKQPWY-QL----SNNEVIECITQGRV----LQRPRTCP------------------------------------QEVYELMLGCWQREPHMRKN------IK-GIHTL--L--------------
--I-VLKRELGEGAFGKV---FLAECYNLSPTKDKM-LVAVKALK-D-PTL----AA-RKDFQ-R-------------------------EAELLTNL-Q---HEHIVKFYGVCGD--------GDPLIMVFEYMKHGDLNKFLR----AHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLAS-QHFVHRDLATRNCLVG-ANLLV---------KIGDFGMSRDV--Y--S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM------YRK----FTTESDVWSFGVILWEIFTYGKQPWF-QL----SNTEVIECITQGRV----LERPRVCP------------------------------------KEVYDVMLGCWQREPQQRLN------IK-EIYKIL----------------
---YELQETLGKGTYGKV---KRATER-----FSGR-VVAIKSIRKD-KIKD---EQ--DMVHIR------------------------REIEIMSSL-N---HPHIISIYEVFEN--------KDKIVIIMEYASKGELYDYIS---ERR-----------------RLSERETRHFFRQIVSAVHYCHK-NGVVHRDLKLENILLD-DNCNI---------KIADFGLSNL------YQKDKFL--------------QT---FCGSPLYASPEIVN-----GRPY----RGPEVDSWALGVLLYTLVY-GTMPFD-GF-------DHKNLIRQISS----GEYREPTQP-----------------------------------SDARGLIRWMLMVNPDRRAT------IE-DIANHWW-V-------------
---YEPKEILGRGVSSVV---RRCIHK-----PTSQ-EYAVKVIDVT-GGGS---FS--PEEVRELRE------------------ATLKEVDILRKVSG---HPNIIQLKDTYET--------NTFFFLVFDLMKRGELFDYLT---EKV-----------------TLSEKETRKIMRALLEVICTLHK-LNIVHRDLKPENILLD-DNMNI---------KLTDFGFSCQ------LEPGERL--------------RE---VCGTPSYLAPEIIECSMNEDHPG----YGKEVDMWSTGVIMYTLLA-GSPPFW-HR-------KQMLMLRMIMS----GNYQFGSPEWDDYS------------------------------DTVKDLVSRFLVVQPQNRYT------AE-EALAHPFF--------------
YDP---KDVIGRGVSSVV---RRCVHR-----ATGH-EFAVKIMEVT-AERL---SP--EQLEEVREA-------------------TRRETHILRQVAG---HPHIITLIDSYES--------SSFMFLVFDLMRKGELFDYLT---EKV-----------------ALSEKETRSIMRSLLEAVSFLHA-NNIVHRDLKPENILLD-DNMQI---------RLSDFGFSCH------LEPGEKL--------------RE---LCGTPGYLAPEILKCSMDETHPG----YGKEVDLWACGVILFTLLA-GSPPFW-HR-------RQILMLRMIME----GQYQFSSPEWDDRS------------------------------STVKDLISRLLQVDPEARLT------AE-QALQHPFF--------------
--F-KFLAVLGRGHFGKV---LLSEFR-----PSGE-LFAIKALKKG-DIVA---RD--EVESLM------------------------CEKRILAAV-TSAGHPFLVNLFGCFQT--------PEHVCFVMEYSAGGDLMLHIH----SD-----------------VFSEPRAIFYSACVVLGLQFLHE-HKIVYRDLKLDNLLLD-TEGYV---------KIADFGLCKEG-----MGYGDRT--------------ST---FCGTPEFLAPEVLT------DTS----YTRAVDWWGLGVLLYEMLV-GESPFP-GD-------DEEEVFDSIVN----DEVRYPRFLS----------------------------------AEAIGIMRRLLRRNPERRLGSS-ERDAE-DVKKQPFF--------------
--F-NFLMVLGKGSFGKV---MLADRK-----GTEE-LYAIKILKKD-VVIQ---DD--DVECTM------------------------VEKRVLALLDK---PPFLTQLHSCFQT--------VDRLYFVMEYVNGGDLMYHIQ---QVG-----------------KFKEPQAVFYAAEISIGLFFLHK-RGIIYRDLKLDNVMLD-SEGHI---------KIADFGMCKEH-----MMDGVTT--------------RT---FCGTPDYIAPEIIA------YQP----YGKSVDWWAYGVLLYEMLA-GQPPFD-GE-------DEDELFQSIME----HNVSYPKSLS----------------------------------KEAVSVCKGLMTKHPAKRLG------C----------GPEGERDVREHAFF
--F-NFLMVLGKGSFGKV---MLSERK-----GTDE-LYAVKILKKD-VVIQ---DD--DVECTM------------------------VEKRVLALPGK---PPFLTQLHSCFQT--------MDRLYFVMEYVNGGDLMYHIQ---QVG-----------------RFKEPHAVFYAAEIAIGLFFLQS-KGIIYRDLKLDNVMLD-SEGHI---------KIADFGMCKEN-----IWDGVTT--------------KT---FCGTPDYIAPEIIA------YQP----YGKSVDWWAFGVLLYEMLA-GQAPFE-GE-------DEDELFQSIME----HNVAYPKSMS----------------------------------KEAVAICKGLMTKHPGKRLG------C----------GPEGERDIKEHAFF
-FI--FHKVLGKGSFGKV---LLGELK-----GRGE-YFAIKALKKD-VVLI---DD--DVECTM------------------------VEKRVLTLAAE---NPFLTHLICTFQT--------KDHLFFVMEFLNGGDLMYHIQ---DKG-----------------RFELYRATFYAAEIMCGLQFLHS-KGIIYRDLKLDNVLLD-RDGHI---------KIADFGMCKEN-----IFGESRA--------------ST---FCGTPDYIAPEILQ------GLK----YTFSVDWWSFGVLLYEMLI-GQSPFH-GD-------DEDELFESIRV----DTPHYPRWIT----------------------------------KESKDILEKLFEREPTKRLG-----VTG-NIKIHPFF--------------
-FI--LHKMLGKGSFGKV---FLAEFK-----KTNQ-FFAIKALKKD-VVLM---DD--DVECTM------------------------VEKRVLSLAWE---HPFLTHMFCTFQT--------KENLFFVMEYLNGGDLMYHIQ---SCH-----------------KFDLSRATFYAAEIILGLQFLHS-KGIVYRDLKLDNILLD-KDGHI---------KIADFGMCKEN-----MLGDAKT--------------NT---FCGTPDYIAPEILL------GQK----YNHSVDWWSFGVLLYEMLI-GQSPFH-GQ-------DEEELFHSIRM----DNPFYPRWLE----------------------------------KEAKDLLVKLFVREPEKRLG------VRGDIRQHPLF--------------
---FELLKVLGQGSFGKVFLVRKVTRP-----DSGH-LYAMKVLKKA-TLKV---RD--RVRTKM-------------------------ERDILADV-N---HPFVVKLHYAFQT--------EGKLYLILDFLRGGDLFTRLS---KEV-----------------MFTEEDVKFYLAELALGLDHLHS-LGIIYRDLKPENILLD-EEGHI---------KLTDFGLSKEA-----IDHEKKA--------------YS---FCGTVEYMAPEVVN------RQG----HSHSADWWSYGVLMFEMLT-GSLPFQ-GK-------DRKETMTLILK----AKLGMPQFLS----------------------------------TEAQSLLRALFKRNPANRLGSG-PDGAE-EIKRHV--FY------------
---YDIEGTLGKGNFAVV---KLGRHR-----ITKT-EVAIKIIDKS-QLDA---VN--LEKIYR-------------------------EVQIMKML-D---HPHIIKLYQVMET--------KSMLYLVTEYAKNGEIFDYLA---NHG-----------------RLNESEARRKFWQILSAVDYCHG-RKIVHRDLKAENLLLD-NNMNI---------KIADFGFGNF------FKSGELL--------------AT---WCGSPPYAAPEVFE-----GQQY----EGPQLDIWSMGVVLYVLVC-GALPFD-GP-------TLPILRQRVLE----GRFRIPYFMS----------------------------------EDCEHLIRRMLVLDPSKRLT------IA-QIKEHKWM--------------
--L-RLEVKLGQGCFGEV---WMGTWN------GTT-RVAIKTLK-P-GTM----SP--EAFL-Q-------------------------EAQVMKKL-R---HEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK----GE--------------TGKYLRLPQLVDMAAQIASGMAYVER-MNYVHRDLRAANILVG-ENLVC---------KVADFGLARLI-----E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR----FTIKSDVWSFGILLTELTTKGRVPYP-GM----VNREVLDQVERGYR----MPCPPECP------------------------------------ESLHDLMCQCWRKEPEERPT------FE-YLQAF--L--------------
---WEIVGELGDGAFGKV---YKAKNK-----ETGA-LAAAKVIETK-SEEE---LE--DYI--V-------------------------EIEILATC-D---HPYIVKLLGAYYH--------DGKLWIMIEFCPGGAVDAIML--ELDR-----------------GLTEPQIQVVCRQMLEALNFLHS-KRIIHRDLKAGNVLMT-LEGDI---------RLADFGVSAKN-----LKTLQKR--------------DS---FIGTPYWMAPEVVMCE-TMKDTP----YDYKADIWSLGITLIEMAQ-IEPPHH-EL----NPMRVLLKIAKSDP----PTLLTPSKWS----------------------------------VEFRDFLKIALDKNPETRPS------AA-QLLEHPFV--------------
LCP---GRELGRGKFAVV---RKCIKK-----DSGK-EFAAKFMRKR-RKGQ---DC--RMEIIH-------------------------EIAVLELAQD---NPWVINLHEVYET--------ASEMILVLEYAAGGEIFDQCVA-DREE-----------------AFKEKDVQRLMRQILEGVHFLHT-RDVVHLDLKPQNILLT-SESPLG------DIKIVDFGLSRI------LKNSEEL--------------RE---IMGTPEYVAPEILS------YDP----ISMATDMWSIGVLTYVMLT-GISPFL-GN-------DKQETFLNISQ----MNLSYSEEEFDVLS------------------------------ESAVDFIRTLLVKKPEDRAT------AE-ECLKHPWL--------------
---YTFGRILGKGSFGIV---IEATDK-----ETET-KWAIKKVNKE-KAGS---SA--VKLLER-------------------------EVNILKSV-K---HEHIIHLEQVFET--------PKKMYLVMELCEDGELKEILD---RKG-----------------HFSENETRWIIQSLASAIAYLHN-NDIVHRDLKLENIMVK-SSLIDDNNEINLNIKVTDFGLAVKK----QSRSEAML--------------QA---TCGTPIYMAPEVIS------AHD----YSQQCDIWSIGVVMYMLLR-GEPPFL-AS-------SEEKLFELIRK----GELHFENAVWNSIS------------------------------DCAKSVLKQLMKVDPAHRIT------AK-ELLDNQWL--------------
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