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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PRKCZ 203
TK ABL1 261
Other AURKA 133
Other AURKB 77
CMGC CDC2 4
CMGC CDK2 4
CAMK CHEK1 9
TK EGFR 712
CMGC GSK3B 56
TK JAK2 849
TK JAK3 822
TK LCK 245
AGC PRKCD 349
AGC PRKCQ 380
TK RET 724
-F-DLIRVIGRGSYAKVLLVRLK-----KNDQIYAMKVVKKEL-VHDDE--DIDWVQTEKHVFEQASSNPFLVGLHSCFQ--T----TSRLF--LVIEYVNGG--DLMFHMQ----RQR-------------------------KLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLD-ADGHIKLTDYGMCKEG----LGPGDTTST---FCGTPNYIAPEILR-GEEYGFSVDWWALGVLMFEMMA-GRSP---------------FDIITDNPDMNTEDYLFQVILEKPIRIPRFLS--------------------------VKASHVLKGFLNKDPKERLGCRPQTGF----------SDIKSHAFF
--ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLK-ED-TM-EV--EEFL-K-EAAVMKEI-KHPNLVQLLGVCT--R----EPPFY--IITEFMTYG--NLLDYLR-----EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLVKVADFGLSRLM----T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI----DLSQVYELLEKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPS------FA-EIHQA--F---------
--FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKAQLEKAGV--EHQLRR-EVEIQSHL-RHPNILRLYGYFH--D----ATRVY--LILEYAPLG--TVYRELQ----KLS-------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN-------TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPM------LR-EVLEHPWI---------
--FEIGRPLGKGKFGNVYLAREK-----KSHFIVALKVLFKSQ-IEKEG--VEHQLRREIEIQAHL-HHPNILRLYNYFY--D----RRRIY--LILEYAPRG--ELYKELQ----KSC-------------------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGELKIADFGWSV------HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA-------SHNETYRRIVKVDLKFPASVP--------------------------MGAQDLISKLLRHNPSERLP------LA-QVSAHPWV---------
--YTKIEKIGEGTYGVVYKGRHK-----TTGQVVAMKKIRLES-EEEGV--PSTAIR-EISLLKEL-RHPNIVSLQDVLM--Q----DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD----SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS------GK-MALNHPYF---------
--FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDT-ETEGV--PSTAIR-EISLLKEL-NHPNIVKLLDVIH--T----ENKLY--LVFEFLHQ---DLKKFMDA--SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD----SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS------AK-AALAHPFF---------
-W-DLVQTLGEGAYGEVQLAVNR-----VTEEAVAVKIVDMKR-AVDCP--ENI-KK-EICINKML-NHENVVKFYGHRR--E----GNIQY--LFLEYCSGG--ELFDRIE----PDI-------------------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNLKISDFGLATVFR--YNNRERLLNK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELP---------------WDQP------SDSCQEYSDWKEKKTYLNPWKKI--D----------------------SAPLALLHKILVENPSARIT------IP-DIKKDRW-Y--------
-F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-EA-TS-PKANKEIL-D-EAYVMASV-DNPHVCRLLGICL-------TSTVQ--LITQLMPFG--CLLDYVR-----EH-----------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVK-TPQHVKITDFGLAKLL--G-A--EEKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI----PASEISSILEKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPK------FR-ELI----IEF-------
--YTDTKVIGNGSFGVVYQAKLC-----DSGELVAIKKVLQDK-RFKNR---------ELQIMRKL-DHCNIVRLRYFFY--SSGEKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-------------------------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD----SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT------PL-EACAHSFF---------
--LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQ-HS-TE--EHLRDFE-R-EIEILKSL-QHDNIVKYKGVCYSAG----RRNLK--LIMEYLPYG--SLRDYLQ-----KH-----------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRVKIGDFGLTKVL-PQ-D--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM----IVFHLIELLKNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPS------FR-DLA----LRV-------
-L-KYISQLGKGNFGSVELCRYDP-LGDNTGALVAVKQLQ-HS-GP-DQ-QRDFQ-R-EIQILKAL-HSDFIVKYRGVSYGPG----RQSLR--LVMEYLPSG--CLRDFLQ-----RH-----------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE-SEAHVKIADFGLAKLL-PL-D--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDV-P--ALCRLLELLEEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPS------FS-ALGP---QL--------
--LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLK-QG-SM-SP--DAFL-A-EANLMKQL-QHQRLVRLYAVVT-------QEPIY--IITEYMENG--SLVDFLK-----TP----------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM----TNPEVIQNLERGYRMVRPDNCP----------------------------EELYQLMRLCWKERPEDRPT------FD-YLRSV--L---------
FI--FHKVLGKGSFGKVLLGELK-----GRGEYFAIKALKKDV-VLIDD--DVECTMVEKRVLTLAAENPFLTHLICTFQ--T----KDHLF--FVMEFLNGG--DLMYHIQ----DKG-------------------------RFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLD-RDGHIKIADFGMCKEN----IFGESRAST---FCGTPDYIAPEILQ-GLKYTFSVDWWSFGVLLYEMLI-GQSP---------------FHGD-------DEDELFESIRVDTPHYPRWIT--------------------------KESKDILEKLFEREPTKRLG-----VTG-NIKIHPFF---------
FI--LHKMLGKGSFGKVFLAEFK-----KTNQFFAIKALKKDV-VLMDD--DVECTMVEKRVLSLAWEHPFLTHMFCTFQ--T----KENLF--FVMEYLNGG--DLMYHIQ----SCH-------------------------KFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLD-KDGHIKIADFGMCKEN----MLGDAKTNT---FCGTPDYIAPEILL-GQKYNHSVDWWSFGVLLYEMLI-GQSP---------------FHGQ-------DEEELFHSIRMDNPFYPRWLE--------------------------KEAKDLLVKLFVREPEKRLG------VRGDIRQHPLF---------
-L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-EN-AS-PSELRDLL-S-EFNVLKQV-NHPHVIKLYGACS--Q----DGPLL--LIVEYAKYG--SLRGFLR-----ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA-EGRKMKISDFGLSRDV--Y-E--EDSYVKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI----PPERLFNLLKTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPV------FA-DISKDL-----------
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