Protein Surface  Ribbon
Inhibitor 537
  ATP Location
Motifs All P-loop B3 Hinge
C-loop A-loop
Select Anchor
Summary of 10 kinases in KIF 1PMVA_537 (MAPK10, PDB code: 1PMV, chain A)

Multiple sequence alignment of family kinases

Conserved residues:   
                            
Group      Kinase           
CAMK       PRKD3        203 
CMGC       CDK2           4 
CMGC       CDK5           4 
CAMK       CHEK2        220 
CMGC       MAPK10        64 
CMGC       MAPK12        27 
CMGC       MAPK8         26 
CMGC       MAPK9         26 
CAMK       PRKD1        583 
CAMK       PRKD2        551 



FAD----EVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRN------EVAILQNLHHPGIVNLECMFET------PERVFVVMEKLHGDMLEMILS-SEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARI-IGEKSFRRSVVGTPAYLAPEVLR---SKGYNRSLDMWSVGVIIYVSLS-GTFPFNED-----EDINDQIQNAAFMYPPNPWREIS-----------------------------------GEAIDLINNLLQVKMRKRYSVDKSLSHPWL
---FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR------EISLLKELNHPNIVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI---KLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
---YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR------EICLLKELKHKNIVRLHDVLHS------DKKLTLVFEFCDQ-DLKKYFD-SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGEL---KLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF--GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF
-YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFF-D------AEDYYIVLELMEGGELFDKVV--GNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI-LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL
---YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYR------ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ----MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL---KILDFGLART-AGTSFMMTPYVVTRYYRAPEVIL---GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI
---YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYR------ELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGT-DLGKLMK---HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCEL---KILDFGLAR---QADSEMTGYVVTRWYRAPEVIL--NWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-----------KKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF
---YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYR------ELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQ----MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL---KILDFGLART-AGTSFMMTPYVVTRYYRAPEVIL---GMGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI
---YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYR------ELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIH----MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL---KILDFGLART-ACTNFMMTPYVVTRYYRAPEVIL---GMGYKENVDIWSVGCIMGELVK-GCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI
-PD----EVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRN------EVAILQNLHHPGVVNLECMFET------PERVFVVMEKLHGDMLEMILS-SEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARI-IGEKSFRRSVVGTPAYLAPEVLR---NKGYNRSLDMWSVGVIIYVSLS-GTFPFNED-----EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------HEAIDLINNLLQVKMRKRYSVDKTLSHPWL
-PD----EVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRN------EVAILQSLRHPGIVNLECMFET------PEKVFVVMEKLHGDMLEMILS-SEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARI-IGEKSFRRSVVGTPAYLAPEVLL---NQGYNRSLDMWSVGVIMYVSLS-GTFPFNED-----EDINDQIQNAAFMYPASPWSHIS-----------------------------------AGAIDLINNLLQVKMRKRYSVDKSLSHPWL