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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK PTK2 203
TK ALK 1116
Other AURKA 133
CMGC CDK2 4
TK EGFR 712
TK FGFR1 478
TK FGFR2 481
TK HCK 241
TK INSR 1023
TK MET 1078
Other NEK2 8
Other PLK4 12
TK PTK2B 425
TK SRC 270
STE STK24 24
TK ZAP70 338
----IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-NC-TS-DSVREKFL-Q-EALTMRQF-DHPHIVKLIGVIT----ENPVWIIMELCTLGELRSFLQ-----VR---------------KYSLDLASLILYAYQLSTALAYLESK-----RFVHRDIAARNVLVSS---NDCVKLGDFGLSRYM--E--DSTY--YKASKGKLPIKWMAPESIN-FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCP----------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL----
---I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-EV-CS-EQDELDFL-M-EALIISKF-NHQNIVRCIGVSL-Q--SLPRFILLELMAGGDLKSFLR-----ETRP---------RPSQPSSLAMLDLLHVARDIACGCQYLEEN-----HFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI-YR--ASYY--RKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCP----------------------------GPVYRIMTQCWQHQPEDRPNFAIILER--I--
----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKAGV--EHQLRR-EVEIQSHL-RHPNILRLYGYFH-D--ATRVYLILEYAPLGTVYRELQ----KLS-----------------KFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLGS---AGELKIADFGWSV----HAPSSRR--TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDT-ETEGV--PSTAIR-EISLLKEL-NHPNIVKLLDVIH-T--ENKLYLVFEFLHQ-DLKKFMDA--SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLINT---EGAIKLADFGLARAF--GVPVRTY--TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-EA-TS-PKANKEIL-D-EAYVMASV-DNPHVCRLLGICL----TSTVQLITQLMPFGCLLDYVR-----EH---------------KDNIGSQYLLNWCVQIAKGMNYLEDR-----RLVHRDLAARNVLVKT---PQHVKITDFGLAKLL-GA--EEKE--YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SD-AT-EKDLSDLI-S-EMEMMKMIGKHKNIINLLGACT-Q--DGPLYVIVEYASKGNLREYLQ-----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK-----KCIHRDLAARNVLVTE---DNVMKIADFGLARDI-HH--IDYY--KKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL----
----LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DD-AT-EKDLSDLV-S-EMEMMKMIGKHKNIINLLGACT-Q--DGPLYVIVEYASKGNLREYLR-----ARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ-----KCIHRDLAARNVLVTE---NNVMKIADFGLARDI-NN--IDYY--KKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL----
----LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-PG-SM-SV--EAFL-A-EANVMKTL-QHDKLVKLHAVVT----KEPIYIITEFMAKGSLLDFLK-----SD--------------EGSKQPLPKLIDFSAQIAEGMAFIEQR-----NYIHRDLRAANILVSA---SLVCKIADFGLARVI--E--DNEY--TAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCP----------------------------EELYNIMMRCWKNRPEERPTFEYIQSV--L--
----ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-ES-AS-LRERIEFL-N-EASVMKGF-TCHHVVRLLGVVS-K--GQPTLVVMELMAHGDLKSYLR-----SLRPEA------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK-----KFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI-YE--TDYY--RKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCP----------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL----
----VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSLN-RI-TD-IGEVSQFL-T-EGIIMKDF-SHPNVLSLLGICLRS--EGSPLVVLPYMKHGDLRNFIR-----NE---------------THNPTVKDLIGFGLQVAKGMKYLASK-----KFVHRDLAARNCMLDE---KFTVKVADFGLARDM-YD--KEYYSVHNKTGAKLPVKWMALESLQ-TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCP----------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I--
----YEVLYTIGTGSYGRCQKIRRK-------SDGKILVWKELDYGS-MTEAE--KQMLVS-EVNLLREL-KHPNIVRYYDRII-DRTNTTLYIVMEYCEGGDLASVITKGTKERQ-----------------YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDG---KQNVKLGDFGLARIL--NHDTSFA--KT---FVGTPYYMSPEQMN-RMSYNEKSDIWSLGCLLYELCA-LMPPFTAF---SQKELAGKIREGKFRRIPYRY---S----------------------DELNEIITRMLNLKDYHRPSVEEILENPL-I-
---F-KVGNLLGKGSFAGVYRAESI-------HTGLEVAIKMIDKKA-MYKAG--MVQRVQNEVKIHCQL-KHPSILELYNYFE-D--SNYVYLVLEMCHNGEMNRYLK---NRVK-----------------PFSENEARHFMHQIITGMLYLHSH-----GILHRDLTLSNLLLTR---NMNIKIADFGLATQL--KMPHEKH--YT---LCGTPNYISPEIAT-RSAHGLESDVWSLGCMFYTLLI-GRPPFDTD---TVKNTLNKVVLADYEMPSFLS--------------------------IEAKDLIHQLLRRNPADRLSLSSVLDHPFM--
---V-VLNRILGEGFFGEVYEGVYT----NHKGEKINVAVKTCK-KD-CT-LDNKEKFM-S-EAVIMKNL-DHPHIVKLIGIIE----EEPTWIIMELYPYGELGHYLE-----RN---------------KNSLKVLTLVLYSLQICKAMAYLESI-----NCVHRDIAVRNILVAS---PECVKLGDFGLSRYI--E--DEDY--YKASVTRLPIKWMSPESIN-FRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCP----------------------------PVLYTLMTRCWDYDPSDRPRFTELVCS--L--
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PG-TM-SP--EAFL-Q-EAQVMKKL-RHEKLVQLYAVVS----EEPIYIVTEYMSKGSLLDFLK-----GE--------------TGKYLRLPQLVDMAAQIASGMAYVERM-----NYVHRDLRAANILVGE---NLVCKVADFGLARLI--E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP----------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L--
----FTKLEKIGKGSFGEVFKGIDN-------RTQKVVAIKIIDLEE-AEDEI--EDIQ-Q-EITVLSQC-DSPYVTKYYGSYL-K--DTKLWIIMEYLGGGSALDLLE-----PG-----------------PLDETQIATILREILKGLDYLHSE-----KKIHRDIKAANVLLSE---HGEVKLADFGVAGQL--TDTQIKR--NT---FVGTPFWMAPEVIK-QSAYDSKADIWSLGITAIELAR-GEPPHSELHPMKVLFLIPKNNPPTLEGNYS----------------------------KPLKEFVEACLNKEPSFRPTAKELLKHKFI--
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-QG-TE-KADTEEMM-R-EAQIMHQL-DNPYIVRLIGVCQ----AEALMLVMEMAGGGPLHKFLV-----GK---------------REEIPVSNVAELLHQVSMGMKYLEEK-----NFVHRDLAARNVLLVN---RHYAKISDFGLSKALGAD--DSYY--TARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP----------------------------PELYALMSDCWIYKWEDRPDFLTVEQR--M--
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