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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC ROCK1 203
CMGC CDK2 4
AGC GRK6 186
CAMK MAPKAPK2 64
AGC PRKCI 245
---YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA-NSPWVVQLFYAFQD----DRYLYMVMEYMPGGDLVNLMS---NYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHL---KLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYAD---------SLVGTYSKIMNHKNSLTFPDDNDIS----------------------KEAKNLICAFLTDREVRLGRNG------VEEIKRHLFF-
---FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR-EISLLKEL-NHPNIVKLLDVIHT----ENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI---KLADFGLARAF-GVPVRTYTHEVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVTRRALFPGD------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS------AKAALAHPFF-
--F-RQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV-NSRFVVSLAYAYET----KDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHI---RISDLGLAVH--VPEGQTIKGRVGTVGYMAPEVVK----NERYTFSPDWWALGCLLYEMIAGQSPFQQR------KKKIKREEVERLVK-EVPEEYSER--FS----------------------PQARSLCSQLLCKDPAE--RLGCR-GGSAREVKEHPLF-
KVT---SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-------R-EVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE--TTSHNSLTTPCYTPYYVAPEVLG----PEKYDKSCDMWSLGVIMYILLCGYPPFYSN-----HGLAISPGMKTRIRMGQYEFPNPEWSEVS----------------------EEVKMLIRNLLKTEPTQ--RMT------ITEFMNHPWI-
--F-DLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQT----ESRLFFVIEYVNGGDLMFHMQ--RQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHI---KLTDYGMCKEG-LRPGDTTSTFCGTPNYIAPEILR----GEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLS--------------------------VKAASVLKSFLNKDPKE--RLGCHPQTGFADIQGHPF-F
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