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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC ROCK2 203
Other AURKA 133
Other AURKB 77
CMGC CDK2 4
CMGC CDK5 4
CAMK CHEK1 9
CAMK CHEK2 220
CMGC GSK3B 56
TK ITK 363
TK JAK2 849
CMGC MAPK10 64
CMGC MAPK14 24
CMGC MAPK8 26
CMGC MAPK9 26
TK MET 1078
CAMK PIM1 38
AGC PRKACA 44
--YDVVKVIGRGAFGEVQLVRHK----ASQKVYAMKLLSKFE-MIKRS--DSAFFW-----EERDIMAFANSPW--VVQLFYAFQ--D------DRYLY--MVMEYMPGG--DLVNLMS-----NY--DVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLD-KHGHL---KLADFGTCMKM---DETGMVHC--DT---AVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLV-GDTP---------------FYAD---SLVGTYSKIMDHKNSLCFPEDAEIS-----------------------------------KHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF--
--FEIGRPLGKGKFGNVYLAREK----QSKFILALKVLFKAQLEKAGV--EHQLRR------EVEIQSHLRHPN--ILRLYGYFH--D------ATRVY--LILEYAPLG--TVYRELQ----KLS--KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL---KIADFGWSV------HAPSSRR--TT---LCGTLDYLPPEMIE----GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN---TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQ--RPM-----LREVLEHPWI--
--FEIGRPLGKGKFGNVYLAREK----KSHFIVALKVLFKSQ-IEKEG--VEHQLR-----REIEIQAHLHHPN--ILRLYNYFY--D------RRRIY--LILEYAPRG--ELYKELQ----KSC--TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL---KIADFGWSV------HAPSLRR--KT---MCGTLDYLPPEMIE----GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA---SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSE--RLP-----LAQVSAHPWV--
--FQKVEKIGEGTYGVVYKARNK----LTGEVVALKKIRLDT-ETEGV--PSTAIR------EISLLKELNHPN--IVKLLDVIH--T------ENKLY--LVFEFLHQ---DLKKFMDA--SALT--GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF----GVPVRTY--TH---EVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-----AKAALAHPFF--
--YEKLEKIGEGTYGTVFKAKNR----ETHEIVALKRVRLDD-DDEGV--PSSALR------EICLLKELKHKN--IVRLHDVLH--S------DKKLT--LVFEFCDQ---DLKKYFD---SCNG--DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL---KLADFGLARAF----GIPVRCY--SA---EVVTLWYRPPDVLF---GAKLYSTSIDMWSAGCIFAELANAGRPL---------------FPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------TSLVNVVPKLNATGRDLLQNLLKCNPVQ--RIS-----AEEALQHPYF--
-W-DLVQTLGEGAYGEVQLAVNR----VTEEAVAVKIVDMKR-AVDCP--ENI-KK------EICINKMLNHEN--VVKFYGHRR--E------GNIQY--LFLEYCSGG--ELFDRIE----PDI--GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFR--YNNRERLL--NK---MCGTLPYVAPELLK---RREFHAEPVDVWSCGIVLTAMLA-GELP---------------WDQP--SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSA--RIT-----IPDIKKDRW-Y-
YI--MSKTLGSGACGEVKLAFER----KTCKKVAIKIISKRK-FAIGS--AREADPALNVETEIEILKKLNHPC--IIKIKNFF---D------AEDYY--IVLELMEGG--ELFDKVV----GNK--RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI-----LGETSLM--RT---LCGTPTYLAPEVLVS-VGTAGYNRAVDCWSLGVILFICLS-GYPP---------------FSEH--RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKA--RFT-----TEEALRHPWL--
--YTDTKVIGNGSFGVVYQAKLC----DSGELVAIKKVLQDK-RFKNR--------------ELQIMRKLDHCN--IVRLRYFFY--SSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ--TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ-----LVRGEPN--VS---YICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-----PLEACAHSFF--
--LTFVQEIGSGQFGLVHLGYWL-----NKDKVAIKTIR-EG-AM-SE--EDFI-E------EAEVMMKLSHPK--LVQLYGVCL--E------QAPIC--LVFEFMEHG--CLSDYLR-----TQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVG-ENQVI---KVSDFGMTRFV----L--DDQY--TSSTGTKFPVKWASPEVFS----FSRYSSKSDVWSFGVLMWEVFSEGKIP---------------YENRSNSEVVEDISTGFRLYKPRLAS-----------------------------------------THVYQIMNHCWKERPED--RPA-----FSRLLRQL----
--LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-HS-TE--EHLRDFE-R------EIEILKSLQHDN--IVKYKGVCYSAG------RRNLK--LIMEYLPYG--SLRDYLQ-----KHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRV---KIGDFGLTKVL-PQ-D--KEYY--KVKEPGESPIFWYAPESLT----ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCP-----------------------------------------DEIYMIMTECWNNNVNQ--RPS-----FRDLA----LRV
--YQNLKPIGSGAQGIVCAAYDA----VLDRNVAIKKLSRPF-QNQTH--AKRAYR------ELVLMKCVNHKN--IISLLNVFT--PQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M--ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART-----AGTSFMM--TP---YVVTRYYRAPEVIL----GMGYKENVDIWSVGCIMGEMVR-HKIL---------------FPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK--RIS-----VDDALQHPYI--
--YQNLSPVGSGAYGSVCAAFDT----KTGLRVAVKKLSRPF-QSIIH--AKRTYR------ELRLLKHMKHEN--VIGLLDVFT--PARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ--KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR-------HTDDEM--TG---YVATRWYRAPEIML---NWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDK--RIT-----AAQALAHAYF--
--YQNLKPIGSGAQGIVCAAYDA----ILERNVAIKKLSRPF-QNQTH--AKRAYR------ELVLMKCVNHKN--IIGLLNVFT--PQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M--ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART-----AGTSFMM--TP---YVVTRYYRAPEVIL----GMGYKENVDLWSVGCIMGEMVC-HKIL---------------FPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASK--RIS-----VDEALQHPYI--
--YQQLKPIGSGAQGIVCAAFDT----VLGINVAVKKLSRPF-QNQTH--AKRAYR------ELVLLKCVNHKN--IISLLNVFT--PQKTLEEFQDVY--LVMELMDA---NLCQVIH------M--ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART-----ACTNFMM--TP---YVVTRYYRAPEVIL----GMGYKENVDIWSVGCIMGELVK-GCVI---------------FQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDK--RIS-----VDEALRHPYI--
--VHFNEVIGRGHFGCVYHGTLL-DNDGKKIHCAVKSLN-RI-TD-IGEVSQFL-T------EGIIMKDFSHPN--VLSLLGICL-RS------EGSPL--VVLPYMKHG--DLRNFIR-----NETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD-EKFTV---KVADFGLARDM--Y-D--KEYYSVHNKTGAKLPVKWMALESLQ----TQKFTTKSDVWSFGVLLWELMTRGAPP---------------YPDVNTFDITVYLLQGRRLLQPEYCP-----------------------------------------DPLYEVMLKCWHPKAEM--RPS-----FSELVSR--I--
--YQVGPLLGSGGFGSVYSGIRV----SDNLPVAIKHVEKDR-ISDWG--ELPNGTRV--PMEVVLLKKVSSGFSGVIRLLDWFE--R------PDSFV--LILERPEPV-QDLFDFIT----ERG--ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL---KLIDFGSGA------LLKDTVY--TD---FDGTRVYSPPEWIR---YHRYHGRSAAVWSLGILLYDMVC-GDIP---------------FEHD---------EEIIRGQVFFRQRVS---------------------------------------SECQHLIRWCLALRPSD--RPT-----FEEIQNHPWM--
-F-ERIKTLGTGSFGRVMLVKHK----ETGNHYAMKILDKQK-VVKLK--QIEHTL-----NEKRILQAVNFPF--LVKLEFSFK--D------NSNLY--MVMEYVPGG--EMFSHLR----RIG--RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYI---QVTDFGFAK-------RVKGRT--WT---LCGTPEYLAPEIIL----SKGYNKAVDWWALGVLIYEMAA-GYPP---------------FFAD---QPIQIYEKIVSGKVRFPSHFS---------------------------------------SDLKDLLRNLLQVDLTK--RFGNLKNGVNDIKNHKWF--
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