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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC ROCK2 203
Other AURKB 77
CAMK CHEK1 9
CMGC GSK3B 56
CAMK PIM1 38
Other PLK1 53
--YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFW---EERDIMAFANSPW--VVQLFYAFQD----DRYLY--MVMEYMPGG--DLVNLMS-----NYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLD-KHGHLKLADFGTCMKM-DETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYAD---SLVGTYSKIMDHKNSLCFPEDAEIS----------------------KHAKNLICAFLTDREVRLGRNGVEEIRQHPFF-
--FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLR---REIEIQAHLHHPN--ILRLYNYFYD----RRRIY--LILEYAPRG--ELYKELQ----KSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGELKIADFGWSV----HAPSLRRKTMCGTLDYLPPEMIE----GRMHNEKVDLWCIGVLCYELLVGNPPFESA---SHNETYRRIVKVDLKFPASVP--------------------------MGAQDLISKLLRHNPSE--RLPLAQVSAHPWV-
-W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENI-KK----EICINKMLNHEN--VVKFYGHRRE----GNIQY--LFLEYCSGG--ELFDRIE----PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK---RREFHAEPVDVWSCGIVLTAMLAGELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D----------------------SAPLALLHKILVENPSA--RITIPDIKKDRW-Y
--YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR----------ELQIMRKLDHCN--IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTA--RLTPLEACAHSFF-
--YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFER----PDSFV--LILERPEPV-QDLFDFIT----ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA----LLKDTVYTDFDGTRVYSPPEWIR---YHRYHGRSAAVWSLGILLYDMVCGDIPFEHD---------EEIIRGQVFFRQRVS--------------------------SECQHLIRWCLALRPSD--RPTFEEIQNHPWM-
YV--RGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMS---MEISIHRSLAHQH--VVGFHGFFED----NDFVF--VVLELCRRR--SLLELHK----RRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEVKIGDFGLATKV--EYDGERKKTLCGTPNYIAPEVLS----KKGHSFEVDVWSIGCIMYTLLVGKPPFETS---CLKETYLRIKKNEYSIPKHIN--------------------------PVAASLIQKMLQTDPTA--RPTINELLNDEFF-
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