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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC ROCK2 203
TK ABL1 261
Other AURKA 133
Other AURKB 77
CMGC CDC2 4
CMGC CDC2L6 20
CMGC CDK2 4
CMGC CDK4 6
CMGC CDK8 2.7.11.23
Other CHUK 15
CMGC CLK4 159
TK DDR1 572
CMGC DYRK1A 150
Other EIF2AK2 267
CMGC GSK3B 56
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK LCK 245
CMGC MAPK10 64
CMGC MAPK14 24
CMGC MAPK3 42
TK MET 1078
Other PLK1 53
AGC PRKCA 339
AGC PRKCD 349
AGC PRKCQ 380
TK PTK2 422
TK PTK6 191
TK SRC 270
---YDVVKVIGRGAFGEVQLVRHK----------------A-SQK--VYAMKLLSKFE-MIK---RS--DSAFFWEERDIMAFA-N---SPW-----VVQLFYAFQ--D-----------------------------DRY--LY--MVMEYMPGG--DLVNLMS----------NY--------------------DV---PEKWAKFYTAEVVLALDAIHS--MGLIHRDVKPDNMLLD----KHGHL-------------------KLADFGTCMKM----DETGMVHC--DT---AVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLV-GD--TP---------------FYAD--------------SLVGTY----SKIMD---HKNSLCFPEDAEIS---------------------------------------------------------KHAKNLICAFLTDREVRLGRNG-VE-EIRQHPFF--------------
---ITMKHKLGGGQYGEVYEGVWK----------------K-YSL--TVAVKTLK-ED-TM----EV--EEFL-K-EAAVMKEI-K---HPN-----LVQLLGVCT--R-----------------------------EPP--FY--IITEFMTYG--NLLDYLR----------EC-----------------NRQEV---NAVVLLYMATQISSAMEYLEK--KNFIHRDLAARNCLVG----ENHLV-------------------KVADFGLSRLM-----T--GDTY--TAHAGAKFPIKWTAPESLA----YNKFSIKSDVWAFGVLLWEIATYGM--SP---------------YPGI-----------DLSQVYELL----EKDYR---MERPEGCP---------------------------------------------------------------EKVYELMRACWQWNPSD--RPS-FA-EIHQA--F--------------
---FEIGRPLGKGKFGNVYLAREK----------------Q-SKF--ILALKVLFKAQLEKA---GV--EHQLRR-EVEIQSHL-R---HPN-----ILRLYGYFH--D-----------------------------ATR--VY--LILEYAPLG--TVYRELQ---------KLS--------------------KF---DEQRTATYITELANALSYCHS--KRVIHRDIKPENLLLG----SAGEL-------------------KIADFGWSV-------HAPSSRR--TT---LCGTLDYLPPEMIE----GRMHDEKVDLWSLGVLCYEFLV-GK--PP---------------FEAN--------------TYQETY----KRISR---VEFTFPDFVT-------------------------------------------------------------EGARDLISRLLKHNPSQ--RPM-LR-EVLEHPWI--------------
---FEIGRPLGKGKFGNVYLAREK----------------K-SHF--IVALKVLFKSQ-IEK---EG--VEHQLRREIEIQAHL-H---HPN-----ILRLYNYFY--D-----------------------------RRR--IY--LILEYAPRG--ELYKELQ---------KSC--------------------TF---DEQRTATIMEELADALMYCHG--KKVIHRDIKPENLLLG----LKGEL-------------------KIADFGWSV-------HAPSLRR--KT---MCGTLDYLPPEMIE----GRMHNEKVDLWCIGVLCYELLV-GN--PP---------------FESA--------------SHNETY----RRIVK---VDLKFPASVP-------------------------------------------------------------MGAQDLISKLLRHNPSE--RLP-LA-QVSAHPWV--------------
---YTKIEKIGEGTYGVVYKGRHK----------------T-TGQ--VVAMKKIRLES-EEE---GV--PSTAIR-EISLLKEL-R---HPN-----IVSLQDVLM--Q-----------------------------DSR--LY--LIFEFLSM---DLKKYLDS------IPPGQ--------------------YM---DSSLVKSYLYQILQGIVFCHS--RRVLHRDLKPQNLLID----DKGTI-------------------KLADFGLARAF-----GIPIRVY--TH---EVVTLWYRSPEVLL---GSARYSTPVDIWSIGTIFAELAT-KK--PL---------------FHGD-----------SEIDQLFRI----FRALG---TPNNEVWPEVESLQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAK--RIS-GK-MALNHPYF--------------
EGC-----KVGRGTYGHVYKARRK----------------D-GKDEKEYALKQIEGTG-ISM---SA--C----R-EIALLREL-K---HPN-----VIALQKVFL--SH---------------------------SDRK--VW--LLFDYAEH---DLWHIIKFHR--ASKANKK--------------------PMQ-LPRSMVKSLLYQILDGIHYLHA--NWVLHRDLKPANILVMGEGPERGRV-------------------KIADMGFARLFN--SPLKPLADL--DP---VVVTFWYRAPELLL---GARHYTKAIDIWAIGCIFAELLT-SE--PI---------------FHCRQEDI--KTSNPFHHDQLDRI----FSVMG---FPADKDWEDIRKMPEYPTLQKDFRRTTYA--------------------------NSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTK--RIT-SE-QALQDPYF--------------
---FQKVEKIGEGTYGVVYKARNK----------------L-TGE--VVALKKIRLDT-ETE---GV--PSTAIR-EISLLKEL-N---HPN-----IVKLLDVIH--T-----------------------------ENK--LY--LVFEFLHQ---DLKKFMDA-------SALT--------------------GI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN----TEGAI-------------------KLADFGLARAF-----GVPVRTY--TH---EVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVT-RR--AL---------------FPGD-----------SEIDQLFRI----FRTLG---TPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-AK-AALAHPFF--------------
--Y-EPVAEIGVGAYGTVYKARDP----------------H-SGH--FVALKSVRVPN-GGGGGGGL--PISTVR-EVALLRRL-EAFEHPN-----VVRLMDVCA--TSR------------------------TDREIK--VT--LVFEHVDQ---DLRTYLDK-------APPP--------------------GL---PAETIKDLMRQFLRGLDFLHA--NCIVHRDLKPENILVT----SGGTV-------------------KLADFGLARI------YSYQMAL--TP---VVVTLWYRAPEVLL----QSTYATPVDMWSVGCIFAEMFR-RK--PL---------------FCGN-----------SEADQLGKI----FDLIG---LPPEDDWPRDVSLPRGAFPPRGPR-------------------------------------PVQSVVPEMEESGAQLLLEMLTFNPHK--RIS-AF-RALQHSYL--------------
EGC-----KVGRGTYGHVYKAKRK----------------D-GKDDKDYALKQIEGTG-ISM---SA--C----R-EIALLREL-K---HPN-----VISLQKVFL--SH---------------------------ADRK--VW--LLFDYAEH---DLWHIIKFHRASKANKKPV--------------------QL---PRGMVKSLLYQILDGIHYLHA--NWVLHRDLKPANILVMGEGPERGRV-------------------KIADMGFARLFN--SPLKPLADL--DP---VVVTFWYRAPELLL---GARHYTKAIDIWAIGCIFAELLT-SE--PI---------------FHCRQEDI--KTSNPYHHDQLDRI----FNVMG---FPADKDWEDIKKMPEHSTLMKDFRRNTYT--------------------------NCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIK--RIT-SE-QAMQDPYF--------------
--W-EMRERLGTGGFGNVCLYQHR----------------E-LDL--KIAIKSCRLEL-STK---NR--ER-WCH-EIQIMKKL-N---HAN-----VVKACDVPE--ELN------------------------ILIHDV--PL--LAMEYCSGG--DLRKLLNK------PENCC--------------------GL---KESQILSLLSDIGSGIRYLHE--NKIIHRDLKPENIVLQ----DVGGKI----------------IHKIIDLGYAKD------VDQGSLC--TS---FVGTLQYLAPELFE----NKPYTATVDYWSFGTMVFECIA-GY--RP---------------FLHHLQPFTWHEKIKKKDPKCIFA----CEEMS---GEVRFSSHLPQPNSLCS---------------------------------------------------LVVEPMENWLQLMLNWDPQQ--RG-------------GPVDLTLKQ-----
---YEIVDTLGEGAFGKVVECIDH----------------GMDGM--HVAVKIVKNVG-RYR---EA--ARS----EIQVLEHL-NS-TDPNSV-FRCVQMLEWFD--H-----------------------------HGH--VC--IVFELLGL---STYDFIK---------ENS--------------------FLP-FQIDHIRQMAYQICQSINFLHH--NKLTHTDLKPENILFV----KSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA--------TYDDEHH--ST---LVSTRHYRAPEVIL----ALGWSQPCDVWSIGCILIEYYL-GF--TV---------------FQTH-----------DSKEHLAMM----ERILG---PIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRY--------------------VRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQ--RIT-LD-EALQHPFF--------------
---LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKG-HPL--LVAVKILR-PD-AT----KNARNDFL-K-EVKIMSRL-K---DPN-----IIRLLGVCV--Q-----------------------------DDP--LC--MITDYMENG--DLNQFLS----------AHQLEDKAAEGAPGDGQAAQGPTI---SYPMLLHVAAQIASGMRYLAT--LNFVHRDLATRNCLVG----ENFTI-------------------KIADFGMSRNL--Y--A--GDYY--RVQGRAVLPIRWMAWECIL----MGKFTTASDVWAFGVTLWEVLMLCRA-QP---------------FGQL-----------TDEQVIENAGEFFRDQGRQVYLSRPPACP---------------------------------------------------------------QGLYELMLRCWSRESEQ--RPP-FS-QLHRFL----------------
---YEIDSLIGKGSFGQVVKAYDR----------------V-EQE--WVAIKIIKNKK-AFL---NQ--AQI----EVRLLELMNK---HDTEMKYYIVHLKRHFM--F-----------------------------RNH--LC--LVFEMLSY---NLYDLLR----------NT--------------------NFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCN--PKRSAI-------------------KIVDFGSSCQ--------LGQRI--YQ---YIQSRFYRSPEVLL----GMPYDLAIDMWSLGCILVEMHT-GE--PL---------------FSGA-----------NEVDQMNKI----VEVLG---IPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKT--RIQ-PY-YALQHSFF--------------
--F-KEIELIGSGGFGQVFKAKHR----------------I-DGK--TYVIKRVKYNN-EKA---ER---------EVKALAKL-D---HVN-----IVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKC--LF--IQMEFCDKG--TLEQWIEK-------RRGE--------------------KL---DKVLALELFEQITKGVDYIHS--KKLIHRDLKPSNIFLV----DTKQV-------------------KIGDFGLVTS------LKNDGKR--TR---SKGTLRYMSPEQIS----SQDYGKEVDLYALGLILAELLH-VC-DTA---------------FET------------------SKF----FTDLR---DGIISDIFDK--------------------------------------------------------------KEKTLLQKLLSKKPED--RPN-TS-EILR----TLT-----------
---YTDTKVIGNGSFGVVYQAKLC----------------D-SGE--LVAIKKVLQDK-RFK---NR---------ELQIMRKL-D---HCN-----IVRLRYFFY--SSG-------------------------EKKDE--VYLNLVLDYVPETVYRVA---RHY-----SRAKQ--------------------TL---PVIYVKLYMYQLFRSLAYIHS--FGICHRDIKPQNLLLD---PDTAVL-------------------KLCDFGSAKQ------LVRGEPN--VS---YICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLL-GQ--PI---------------FPGD-----------SGVDQLVEI----IKVLG---TPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-PL-EACAHSFF--------------
--L-KRIRDLGEGHFGKVELCRYDP------------EGDN-TGE--QVAVKSLK-PE-SG----GNHIADLK-K-EIEILRNL-Y---HEN-----IVKYKGICT-ED------------------------------GGNGIK--LIMEFLPSG--SLKEYLP----------KN------------------KNKI---NLKQQLKYAVQICKGMDYLGS--RQYVHRDLAARNVLVE----SEHQV-------------------KIGDFGLTKAI-ET--D--KEYY--TVKDDRDSPVFWYAPECLM----QSKFYIASDVWSFGVTLHELLTYCD--SDSSPMALF-LKMIGPTHGQM-----------TVTRLVNTL----KEGKR---LPCPPNCP---------------------------------------------------------------DEVYQLMRKCWEFQPSN--RTS-FQ-NLIE---GF-------------
---LKFLQQLGKGNFGSVEMCRYDP------------LQDN-TGE--VVAVKKLQ-HS-TE-----EHLRDFE-R-EIEILKSL-Q---HDN-----IVKYKGVCYSAG-----------------------------RRN--LK--LIMEYLPYG--SLRDYLQ----------KH------------------KERI---DHIKLLQYTSQICKGMEYLGT--KRYIHRDLATRNILVE----NENRV-------------------KIGDFGLTKVL-PQ--D--KEYY--KVKEPGESPIFWYAPESLT----ESKFSVASDVWSFGVVLYELFTYIE--KSKSPPAEFMRMIGNDKQGQM-----------IVFHLIELL----KNNGR---LPRPDGCP---------------------------------------------------------------DEIYMIMTECWNNNVNQ--RPS-FR-DLA----LRV------------
--L-KYISQLGKGNFGSVELCRYDP------------LGDN-TGA--LVAVKQLQ-HS-GP----DQ-QRDFQ-R-EIQILKAL-H---SDF-----IVKYRGVSYGPG-----------------------------RQS--LR--LVMEYLPSG--CLRDFLQ----------RH------------------RARL---DASRLLLYSSQICKGMEYLGS--RRCVHRDLAARNILVE----SEAHV-------------------KIADFGLAKLL-PL--D--KDYY--VVREPGQSPIFWYAPESLS----DNIFSRQSDVWSFGVVLYELFTYCD--KSCSPSAE--FLRMMGCERDV-P---------ALCRLLELL----EEGQR---LPAPPACP---------------------------------------------------------------AEVHELMKLCWAPSPQD--RPS-FS-ALGP---QL-------------
---LKLVERLGAGQFGEVWMGYYN------------------GHT--KVAVKSLK-QG-SM----SP--DAFL-A-EANLMKQL-Q---HQR-----LVRLYAVVT--------------------------------QEP--IY--IITEYMENG--SLVDFLK----------TP-----------------SGIKL---TINKLLDMAAQIAEGMAFIEE--RNYIHRDLRAANILVS----DTLSC-------------------KIADFGLARLI-----E--DNEY--TAREGAKFPIKWTAPEAIN----YGTFTIKSDVWSFGILLTEIVTHGR--IP---------------YPGM-----------TNPEVIQNL----ERGYR---MVRPDNCP---------------------------------------------------------------EELYQLMRLCWKERPED--RPT-FD-YLRSV--L--------------
---YQNLKPIGSGAQGIVCAAYDA----------------V-LDR--NVAIKKLSRPF-QNQ---TH--AKRAYR-ELVLMKCV-N---HKN-----IISLLNVFT--PQKT-----------------------LEEFQD--VY--LVMELMDA---NLCQVIQ-----------M--------------------EL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVK----SDCTL-------------------KILDFGLART------AGTSFMM--TP---YVVTRYYRAPEVIL----GMGYKENVDIWSVGCIMGEMVR-HK--IL---------------FPGR-----------DYIDQWNKV----IEQLG---TPCPEFMKKLQPTVRNYVENRPKYAGLTFPK----------------------LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK--RIS-VD-DALQHPYI--------------
---YQNLSPVGSGAYGSVCAAFDT----------------K-TGL--RVAVKKLSRPF-QSI---IH--AKRTYR-ELRLLKHM-K---HEN-----VIGLLDVFT--PARS-----------------------LEEFND--VY--LVTHLMGA---DLNNIVK----------CQ--------------------KL---TDDHVQFLIYQILRGLKYIHS--ADIIHRDLKPSNLAVN----EDCEL-------------------KILDFGLAR--------HTDDEM--TG---YVATRWYRAPEIML---NWMHYNQTVDIWSVGCIMAELLT-GR--TL---------------FPGT-----------DHIDQLKLI----LRLVG---TPGAELLKKISSESARNYIQSLTQMP---------------------------------KMNFANVFIGANPLAVDLLEKMLVLDSDK--RIT-AA-QALAHAYF--------------
---YTQLQYIGEGAYGMVSSAYDH----------------V-RKT--RVAIKKISPFE-HQT---YC--QRT-LR-EIQILLRF-R---HEN-----VIGIRDILR--AST------------------------LEAMRD--VY--IVQDLMET---DLYKLLK----------SQ--------------------QL---SNDHICYFLYQILRGLKYIHS--ANVLHRDLKPSNLLIN----TTCDL-------------------KICDFGLARIAD--PEHDHTGFL--TE---YVATRWYRAPEIML---NSKGYTKSIDIWSVGCILAEMLS-NR--PI---------------FPGK-----------HYLDQLNHI----LGILG---SPSQEDLNCIINMKARNYLQSLPSKT---------------------------------KVAWAKLFPKSDSKALDLLDRMLTFNPNK--RIT-VE-EALAHPYL--------------
---VHFNEVIGRGHFGCVYHGTLL-------------DNDG-KKI--HCAVKSLN-RI-TD----IGEVSQFL-T-EGIIMKDF-S---HPN-----VLSLLGICL-RS-----------------------------EGS--PL--VVLPYMKHG--DLRNFIR----------NE------------------THNP---TVKDLIGFGLQVAKGMKYLAS--KKFVHRDLAARNCMLD----EKFTV-------------------KVADFGLARDM--Y--D--KEYYSVHNKTGAKLPVKWMALESLQ----TQKFTTKSDVWSFGVLLWELMTRGA--PP---------------YPDV-----------NTFDITVYL----LQGRR---LLQPEYCP---------------------------------------------------------------DPLYEVMLKCWHPKAEM--RPS-FS-ELVSR--I--------------
-YV--RGRFLGKGGFAKCFEISDA----------------D-TKE--VFAGKIVPKSL-LLK---PH--QREKMSMEISIHRSL-A---HQH-----VVGFHGFFE--D-----------------------------NDF--VF--VVLELCRRR--SLLELHK---------RRK--------------------AL---TEPEARYYLRQIVLGCQYLHR--NRVIHRDLKLGNLFLN----EDLEV-------------------KIGDFGLATKV-----EYDGERK--KT---LCGTPNYIAPEVLS----KKGHSFEVDVWSIGCIMYTLLV-GK--PP---------------FETS--------------CLKETY----LRIKK---NEYSIPKHIN-------------------------------------------------------------PVAASLIQKMLQTDPTA--RPT-IN-ELLNDEFF--------------
--F-NFLMVLGKGSFGKVMLADRK----------------G-TEE--LYAIKILKKDV-VIQ---DD--DVECTMVEKRVLALLDK---PPF-----LTQLHSCFQ--T-----------------------------VDR--LY--FVMEYVNGG--DLMYHIQ---------QVG--------------------KF---KEPQAVFYAAEISIGLFFLHK--RGIIYRDLKLDNVMLD----SEGHI-------------------KIADFGMCKEH-----MMDGVTT--RT---FCGTPDYIAPEIIA----YQPYGKSVDWWAYGVLLYEMLA-GQ--PP---------------FDGE--------------DEDELF----QSIME---HNVSYPKSLS-------------------------------------------------------------KEAVSVCKGLMTKHPAK--RLG-C----------GPEGERDVREHAFF
-FI--FHKVLGKGSFGKVLLGELK----------------G-RGE--YFAIKALKKDV-VLI---DD--DVECTMVEKRVLTLAAE---NPF-----LTHLICTFQ--T-----------------------------KDH--LF--FVMEFLNGG--DLMYHIQ---------DKG--------------------RF---ELYRATFYAAEIMCGLQFLHS--KGIIYRDLKLDNVLLD----RDGHI-------------------KIADFGMCKEN-----IFGESRA--ST---FCGTPDYIAPEILQ----GLKYTFSVDWWSFGVLLYEMLI-GQ--SP---------------FHGD--------------DEDELF----ESIRV---DTPHYPRWIT-------------------------------------------------------------KESKDILEKLFEREPTK--RLGVTG-NIKIHPFF--------------
-FI--LHKMLGKGSFGKVFLAEFK----------------K-TNQ--FFAIKALKKDV-VLM---DD--DVECTMVEKRVLSLAWE---HPF-----LTHMFCTFQ--T-----------------------------KEN--LF--FVMEYLNGG--DLMYHIQ---------SCH--------------------KF---DLSRATFYAAEIILGLQFLHS--KGIVYRDLKLDNILLD----KDGHI-------------------KIADFGMCKEN-----MLGDAKT--NT---FCGTPDYIAPEILL----GQKYNHSVDWWSFGVLLYEMLI-GQ--SP---------------FHGQ--------------DEEELF----HSIRM---DNPFYPRWLE-------------------------------------------------------------KEAKDLLVKLFVREPEK--RLG-VRGDIRQHPLF--------------
---IELGRCIGEGQFGDVHQGIYM-------------SPEN-PAL--AVAIKTCK-NC-TS----DSVREKFL-Q-EALTMRQF-D---HPH-----IVKLIGVIT--------------------------------ENP--VW--IIMELCTLG--ELRSFLQ----------VR------------------KYSL---DLASLILYAYQLSTALAYLES--KRFVHRDIAARNVLVS----SNDCV-------------------KLGDFGLSRYM-----E--DSTY--YKASKGKLPIKWMAPESIN----FRRFTSASDVWMFGVCMWEILMHGV--KP---------------FQGV-----------KNNDVIGRI----ENGER---LPMPPNCP---------------------------------------------------------------PTLYSLMTKCWAYDPSR--RPR-FT-ELKAQL----------------
--F-TLCRKLGSGYFGEVFEGLWK------------------DRV--QVAIKVIS-RD-NL----LH-QQMLQ-S-EIQAMKKL-R---HKH-----ILALYAVVS--V-----------------------------GDP--VY--IITELMAKG--SLLELLR----------DS-----------------DEKVL---PVSELLDIAWQVAEGMCYLES--QNYIHRDLAARNILVG----ENTLC-------------------KVGDFGLARLI--------KEDV--YLSHDHNIPYKWTAPEALS----RGHYSTKSDVWSFGILLHEMFSRGQ--VP---------------YPGM-----------SNHEAFLRV----DAGYR---MPCPLECP---------------------------------------------------------------PSVHKLMLTCWCRDPEQ--RPC-FK-ALRERL----------------
--L-RLEVKLGQGCFGEVWMGTWN------------------GTT--RVAIKTLK-PG-TM----SP--EAFL-Q-EAQVMKKL-R---HEK-----LVQLYAVVS--------------------------------EEP--IY--IVTEYMSKG--SLLDFLK----------GE-----------------TGKYL---RLPQLVDMAAQIASGMAYVER--MNYVHRDLRAANILVG----ENLVC-------------------KVADFGLARLI-----E--DNEY--TARQGAKFPIKWTAPEAAL----YGRFTIKSDVWSFGILLTELTTKGR--VP---------------YPGM-----------VNREVLDQV----ERGYR---MPCPPECP---------------------------------------------------------------ESLHDLMCQCWRKEPEE--RPT-FE-YLQAF--L--------------
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