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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC ROCK2 203
Other AURKB 77
CMGC CDK2 4
CMGC GSK3B 56
TK JAK2 849
CMGC MAPK10 64
CAMK PIM1 38
YDVVKVIGRGAFGEVQLVRHK----ASQKVYAMKLLSKFEMIKRS--DSAFFW---EERDIMAFANSPW--VVQLFYAFQ--D------DRYLY--MVMEYMPGG--DLVNLMS-----NY--DVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLD-KHGHLKLADFGTCMKM--DETGMVHCDT---AVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLV-GDTP---------------FYAD---SLVGTYSKIMDHKNSLCFPEDAEIS-----------------------------------KHAKNLICAFLTDREVRLGRNGVEEIRQHPFF--
FEIGRPLGKGKFGNVYLAREK----KSHFIVALKVLFKSQIEKEG--VEHQLR---REIEIQAHLHHPN--ILRLYNYFY--D------RRRIY--LILEYAPRG--ELYKELQ----KSC--TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGELKIADFGWSV-----HAPSLRRKT---MCGTLDYLPPEMIE----GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA---SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSE--RLPLAQVSAHPWV--
FQKVEKIGEGTYGVVYKARNK----LTGEVVALKKIRLDTETEGV--PSTAIR----EISLLKELNHPN--IVKLLDVIH--T------ENKLY--LVFEFLHQ---DLKKFMDA--SALT--GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF---GVPVRTYTH---EVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RISAKAALAHPFF--
YTDTKVIGNGSFGVVYQAKLC----DSGELVAIKKVLQDKRFKNR------------ELQIMRKLDHCN--IVRLRYFFY--SSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ--TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLTPLEACAHSFF--
LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-HSTE--EHLRDFE-R----EIEILKSLQHDN--IVKYKGVCYSAG------RRNLK--LIMEYLPYG--SLRDYLQ-----KHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRVKIGDFGLTKVLPQ-D--KEYYKVKEPGESPIFWYAPESLT----ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCP-----------------------------------------DEIYMIMTECWNNNVNQ--RPSFRDLA----LRV
YQNLKPIGSGAQGIVCAAYDA----VLDRNVAIKKLSRPFQNQTH--AKRAYR----ELVLMKCVNHKN--IISLLNVFT--PQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M--ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART----AGTSFMMTP---YVVTRYYRAPEVIL----GMGYKENVDIWSVGCIMGEMVR-HKIL---------------FPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK--RISVDDALQHPYI--
YQVGPLLGSGGFGSVYSGIRV----SDNLPVAIKHVEKDRISDWG--ELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFE--R------PDSFV--LILERPEPV-QDLFDFIT----ERG--ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA-----LLKDTVYTD---FDGTRVYSPPEWIR---YHRYHGRSAAVWSLGILLYDMVC-GDIP---------------FEHD---------EEIIRGQVFFRQRVS---------------------------------------SECQHLIRWCLALRPSD--RPTFEEIQNHPWM--
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