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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC ROCK2 203
CMGC CDK2 4
CAMK CHEK1 9
TK JAK1 875
AGC PRKACA 44
CAMK STK33 116
-YDVVKVIGRGAFGEVQLVRHK----ASQKVYAMKLLSKFEMIKRS--DSAFFWEERDIMAFANSPWVVQLFYAFQ-DDRY--LYMVMEYMPGGDLVNLMS---NY--DVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHL---------KLADFGTCMKM---DETGMVHCDT---AVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLV-GDTP--------------FYAD---SLVGTYSKIMDHKNSLCFPEDAEIS----------------------KHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF-
-FQKVEKIGEGTYGVVYKARNK----LTGEVVALKKIRLDTETEGV--PSTAIR-EISLLKELNHPNIVKLLDVIH-TENK--LYLVFEFLHQ-DLKKFMDASALT--GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI---------KLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVT-RRAL--------------FPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-----AKAALAHPFF-
W-DLVQTLGEGAYGEVQLAVNR----VTEEAVAVKIVDMKRAVDCP--ENI-KK-EICINKMLNHENVVKFYGHRR-EGNI--QYLFLEYCSGGELFDRIE--PDI--GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNL---------KISDFGLATVFR--YNNRERLLNK---MCGTLPYVAPELLK---RREFHAEPVDVWSCGIVLTAMLA-GELP--------------WDQP--SDSCQEYSDWKEKKTYLNPWKKI--D----------------------SAPLALLHKILVENPSA--RIT-----IPDIKKDRW-Y
L-KRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLK-PESG-GNHIADLK-K-EIEILRNLYHENIVKYKGICTED-GGNGIKLIMEFLPSGSLKEYLP---KNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQV---------KIGDFGLTKAI-ET-D--KEYYTVKDDRDSPVFWYAPECLM----QSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCP----------------------------DEVYQLMRKCWEFQPSN--RTS-----FQNLIE---GF
F-ERIKTLGTGSFGRVMLVKHK----ETGNHYAMKILDKQKVVKLK--QIEHTLNEKRILQAVNFPFLVKLEFSFK-DNSN--LYMVMEYVPGGEMFSHLR--RIG--RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYI---------QVTDFGFAK-------RVKGRTWT---LCGTPEYLAPEIIL----SKGYNKAVDWWALGVLIYEMAA-GYPP--------------FFAD---QPIQIYEKIVSGKVRFPSHFS--------------------------SDLKDLLRNLLQVDLTK--RFGNLKNGVNDIKNHKWF-
-YTFGRILGKGSFGIVIEATDK----ETETKWAIKKVNKEKAGSSA--VKLLER-EVNILKSVKHEHIIHLEQVFE-TPKK--MYLVMELCEDGELKEILD--RKG--HFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKK---QSRSEAMLQA---TCGTPIYMAPEVIS----AHDYSQQCDIWSIGVVMYMLLR-GEPP--------------FLAS---SEEKLFELIRKGELHFENAVWNSIS----------------------DCAKSVLKQLMKVDPAH--RIT-----AKELLDNQWL-
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