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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC ROCK2 203
Other AURKA 133
Other AURKB 77
CMGC CDC2 4
CMGC CDK5 4
CAMK CHEK1 9
CAMK CHEK2 220
CMGC GSK3B 56
CMGC MAPK10 64
CMGC MAPK14 24
AGC PDPK1 82
CAMK PIM1 38
--YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFE-MIKRSDS-AFFW-----EERDIMAFANSPW--VVQLFYAFQD------DRYLY--MVMEYMPGG--DLVNLMS-----NYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLD-KHGHL---KLADFGTCMKM-DETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLV-GDTPFYAD---SLVGTYSKIMDHKNSLCFPEDAEIS-----------------------------------KHAKNLICAFLTDREVRLGRNGVEEIRQHPFF-----------
--FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEH-QLRR------EVEIQSHLRHPN--ILRLYGYFHD------ATRVY--LILEYAPLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL---KIADFGWSV----HAPSSRRTTLCGTLDYLPPEMIE----GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQ--RPMLREVLEHPWI-----------
--FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ-IEKEGVE-HQLR-----REIEIQAHLHHPN--ILRLYNYFYD------RRRIY--LILEYAPRG--ELYKELQ----KSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL---KIADFGWSV----HAPSLRRKTMCGTLDYLPPEMIE----GRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSE--RLPLAQVSAHPWV-----------
--YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPS-TAIR------EISLLKELRHPN--IVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF--GIPIRVYTHEVVTLWYRSPEVLL---GSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAK--RISGKMALNHPYF-----------
--YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPS-SALR------EICLLKELKHKN--IVRLHDVLHS------DKKLT--LVFEFCDQ---DLKKYFD---SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL---KLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLF---GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------TSLVNVVPKLNATGRDLLQNLLKCNPVQ--RISAEEALQHPYF-----------
-W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR-AVDCPEN-I-KK------EICINKMLNHEN--VVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE----PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK---RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSA--RITIPDIKKDRW-Y----------
YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRK-FAIGSAR-EADPALNVETEIEILKKLNHPC--IIKIKNFF-D------AEDYY--IVLELMEGG--ELFDKVV----GNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI---LGETSLMRTLCGTPTYLAPEVLVS-VGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKA--RFTTEEALRHPWL-----------
--YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-RFKNR-------------ELQIMRKLDHCN--IVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLTPLEACAHSFF-----------
--YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF-QNQTHAK-RAYR------ELVLMKCVNHKN--IISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART---AGTSFMMTPYVVTRYYRAPEVIL----GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK--RISVDDALQHPYI-----------
--YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSIIHAK-RTYR------ELRLLKHMKHEN--VIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR-----HTDDEMTGYVATRWYRAPEIML---NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDK--RITAAQALAHAYF-----------
-F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRH-IIKENKVPYVTR------ERDVMSRLDHPF--FVKLYFTFQD------DEKLY--FGLSYAKNG--ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI---QITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT----EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATK--RLGCEEM------EGYGPLKAHPF
--YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDR-ISDWGEL-PNGTRV--PMEVVLLKKVSSGFSGVIRLLDWFER------PDSFV--LILERPEPV-QDLFDFIT----ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL---KLIDFGSGA----LLKDTVYTDFDGTRVYSPPEWIR---YHRYHGRSAAVWSLGILLYDMVC-GDIPFEHD---------EEIIRGQVFFRQRVS---------------------------------------SECQHLIRWCLALRPSD--RPTFEEIQNHPWM-----------
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