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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC ROCK2 203
Other AURKA 133
Other AURKB 77
CMGC CDK2 4
CAMK CHEK1 9
CMGC CSNK2A1 39
CMGC GSK3B 56
TKL IRAK4 186
CMGC MAPK14 24
CAMK MAPKAPK2 64
CAMK PIM1 38
Other PLK3 62
AGC RPS6KA3 68
TK SRC 270
---YDVVKVIGRGAFGEVQLVRHKASQK---VYAMKLLSKFE-MIKRSD-SAFFW---EERDIMAFA-NSPW--VVQLFYAFQD------DRYLY--MVMEYMPGG--DLVNLMS-----NY---DVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLD-KHGHL---KLADFGTCMKM-DETGMVHCDT---AVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLV-GDTPFY-AD----SLVGTYSKIMDHKNSLCFPEDAEIS------------------------------KHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF---
---FEIGRPLGKGKFGNVYLAREKQSKF---ILALKVLFKAQLEKAGVE-HQLRR----EVEIQSHL-RHPN--ILRLYGYFHD------ATRVY--LILEYAPLG--TVYRELQ----KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL---KIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIE----GRMHDEKVDLWSLGVLCYEFLV-GKPPFE-AN----TYQETYKRISRVEFTFPDFVT----------------------------------EGARDLISRLLKHNPSQ--RPM-----LREVLEHPWI---
---FEIGRPLGKGKFGNVYLAREKKSHF---IVALKVLFKSQ-IEKEGV-EHQLR---REIEIQAHL-HHPN--ILRLYNYFYD------RRRIY--LILEYAPRG--ELYKELQ----KSC---TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL---KIADFGWSV----HAPSLRRKT---MCGTLDYLPPEMIE----GRMHNEKVDLWCIGVLCYELLV-GNPPFE-SA----SHNETYRRIVKVDLKFPASVP----------------------------------MGAQDLISKLLRHNPSE--RLP-----LAQVSAHPWV---
---FQKVEKIGEGTYGVVYKARNKLTGE---VVALKKIRLDT-ETEGVP-STAIR----EISLLKEL-NHPN--IVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-----AKAALAHPFF---
--W-DLVQTLGEGAYGEVQLAVNRVTEE---AVAVKIVDMKR-AVDCPE-NI-KK----EICINKML-NHEN--VVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE----PDI---GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFRYNNRERLLNK---MCGTLPYVAPELLK---RREFHAEPVDVWSCGIVLTAMLA-GELPWD-QP---SDSCQEYSDWKEKKTYLNPWKKI--D------------------------------SAPLALLHKILVENPSA--RIT-----IPDIKKDRW-Y--
---YQLVRKLGRGKYSEVFEAINITNNE---KVVVKILKPVK-KKKIKR----------EIKILENLRGGPN--IITLADIVKDP----VSRTPA--LVFEHVNNT--DFKQLY-------Q---TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL---RLIDWGLAEF---YHPGQEYNV---RVASRYFKGPELLV---DYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGH-DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQS--RLT-----AREAMEHPYF---
---YTDTKVIGNGSFGVVYQAKLCDSGE---LVAIKKVLQDK-RFKNR-----------ELQIMRKL-DHCN--IVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ---LVRGEPNVS---YICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-----PLEACAHSFF---
VGG----NKMGEGGFGVVYKGYVNNTT-----VAVKKLAAMV-DITTEELKQQFD---QEIKVMAKC-QHEN--LVELLGFSSD------GDDLC--LVYVYMPNG--SLLDRLSC-LDGTP---PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLD-EAFTA---KISDFGLARASEKFAQTVMTSR---IVGTTAYMAPEALR-----GEITPKSDIYSFGVVLLEIIT-GLPAVD-EH-REPQLLLDIKEEIEDEEKTIEDYIDKKMNDAD----------------------STSVEAMYSVASQCLHEKKNK--RPD-----IKKVQQ----LLQ
---YQNLSPVGSGAYGSVCAAFDTKTGL---RVAVKKLSRPF-QSIIHA-KRTYR----ELRLLKHM-KHEN--VIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR-----HTDDEMTG---YVATRWYRAPEIML---NWMHYNQTVDIWSVGCIMAELLT-GRTLFP-GT-DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP------KMNFANVFIGANPLAVDLLEKMLVLDSDK--RIT-----AAQALAHAYF---
KVT---SQVLGLGINGKVLQIFNKRTQE---KFALKMLQDCP-KAR--------R----EVELHWRASQCPH--IVRIVDVYENLY--AGRKCLL--IVMECLDGG--ELFSRIQD--RGDQ---AFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT-SKRPNAILKLTDFGFAKE---TTSHNSLTT---PCYTPYYVAPEVLG----PEKYDKSCDMWSLGVIMYILLC-GYPPFY-SNHGLAISPGMKTRIRMGQYEFPNPEWSEVS------------------------------EEVKMLIRNLLKTEPTQ--RMT-----ITEFMNHPWI---
---YQVGPLLGSGGFGSVYSGIRVSDNL---PVAIKHVEKDR-ISDWGE-LPNGTRVPMEVVLLKKV-SSGFSGVIRLLDWFER------PDSFV--LILERPEPV-QDLFDFIT----ERG---ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL---KLIDFGSGA----LLKDTVYTD---FDGTRVYSPPEWIR---YHRYHGRSAAVWSLGILLYDMVC-GDIPFE-HD----------EEIIRGQVFFRQRVS----------------------------------SECQHLIRWCLALRPSD--RPT-----FEEIQNHPWM---
-YL--KGRLLGKGGFARCYEATDTETGS---AYAVKVIPQSR-VAKPHQ-REKIL---NEIELHRDL-QHRH--IVRFSHHFED------ADNIY--IFLELCSRK--SLAHIWK----ARH---TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT-ENMEL---KVGDFGLAARL--EPPEQRKKT---ICGTPNYVAPEVLL----RQGHGPEADVWSLGCVMYTLLC-GSPPFE-TA----DLKETYRCIKQVHYTLPASLS----------------------------------LPARQLLAAILRASPRD--RPS-----IDQILRHDFF---
---FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKAT-LKVRDR-VRTKM----ERDILVEV-NHPF--IVKLHYAFQT------EGKLY--LILDFLRGG--DLFTRLS----KEV---MFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD-EEGHI---KLTDFGLSKES--IDHEKKAYS---FCGTVEYMAPEVVN----RRGHTQSADWWSFGVLMFEMLT-GTLPFQ-GK----DRKETMTMILKAKLGMPQFLS----------------------------------PEAQSLLRMLFKRNPAN--RLGAGPDGVEEIKRHSFF---
--L-RLEVKLGQGCFGEVWMGTWN-GTT---RVAIKTLK-PG-TM-SPE-AFL-Q----EAQVMKKL-RHEK--LVQLYAVVS-------EEPIY--IVTEYMSKG--SLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVC---KVADFGLARLI--E--DNEYTARQGAKFPIKWTAPEAAL----YGRFTIKSDVWSFGILLTELTTKGRVPYP-GM-VNREVLDQVERGYRMPCPPECP------------------------------------ESLHDLMCQCWRKEPEE--RPT-----FEYLQAF--L---
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