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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC RPS6KA2 203
TK ABL1 261
TK ALK 1116
TK AXL 527
TK BLK 241
TK BMX 422
TK BTK 402
TK CSF1R 582
TK CSK 195
TK DDR1 572
TK DDR2 563
TK EGFR 712
TK EPHA1 624
TK EPHA3 621
TK EPHB1 619
TK EPHB2 621
TK EPHB3 633
TK EPHB4 615
TK EPHB6 670
TK ERBB2 720
TK ERBB4 718
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FLT4 845
TK FYN 271
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK INSRR 979
TKL IRAK4 186
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK KDR 834
TK KIT 589
TK LCK 245
TKL LIMK1 339
TKL LIMK2 331
TK LTK 510
STE MAP3K15 649
STE MAP3K6 645
TKL MAP3K7 36
TK MATK 235
TK MERTK 587
TK MET 1078
TK MST1R 1082
TK MUSK 575
TK NTRK1 510
TK NTRK2 538
STE PAK4 321
TK PDGFRA 593
TK PDGFRB 600
Other PLK1 53
TK PTK2 422
TK PTK2B 425
TK PTK6 191
TK RET 724
TKL RIPK2 18
TKL RIPK4 22
TK ROS1 1945
AGC RPS6KA1 62
AGC RPS6KA3 68
STE SLK 34
TK SRC 270
TK SRMS 230
STE STK24 24
STE STK3 27
Other STK36 4
STE STK4 30
TK SYK 371
TK TEC 370
TK TEK 824
TK TIE1 839
TK TNK1 116
TK TNK2 150
TKL TNNI3K 463
TK TXK 271
TK TYK2 589
TK TYRO3 518
Other ULK1 16
Other ULK2 9
TK YES1 277
STE YSK4 1162
TK ZAP70 338
----FELLKVLGQGSYGKV---FLVRKV----------------KGSDAGQLYAM-KVL---KKA--TLKVRD---R-VRSKM----ERDILAEV-NHPFIVKLHYAFQ--TEGK------LYLILDFLRGGDLFTRLS---KEV-----------------------------------------------------------------------------------------------------MF---TEEDVKFYLAELALALDHLHS--L--G---IIYRDLKPENILLD-E-----EG-HI---------KITDFGLSKEA-----------------IDHDKRA------------YS---FCGTIEYMAPEVVN-----RRG-HTQSADWWSFGVLMFEMLT-GS-LP---------------FQGK------DRKETM----AL----ILK---AKLGMPQFLS------------GEAQS-LLRALFKRNPCNRLGAGIDGVEEIKRHPFF-----
----ITMKHKLGGGQYGEV---YEGVWK----------------KYSL---TVAV-KTL---K-E--DTM-EV---E-EFL-K----EAAVMKEI-KHPNLVQLLGVCT--REPP------FYIITEFMTYGNLLDYLR----EC-------------------------------------------------------------------------------------------------NR-QEV---NAVVLLYMATQISSAMEYLEK--K--N---FIHRDLAARNCLVG-E-----NH-LV---------KVADFGLSRLM-----------------T--GDTY------------TAHAGAKFPIKWTAPESLA-----YNK-FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI---DLSQVYELL----EK----DYR---MERPEGCP--------------EKVYE-LMRACWQWNPSDRPS-----FAEIHQA--F-----
---I-TLIRGLGHGAFGEV---YEGQVSG-----------MPNDPSPL---QVAV-KTL---P-E--VCS-EQD-EL-DFL-M----EALIISKF-NHQNIVRCIGVSL--QSLP------RFILLELMAGGDLKSFLR----ETRP--------------------------------------------------------------------------------------------RPSQP-SSL---AMLDLLHVARDIACGCQYLEE--N--H---FIHRDIAARNCLLT-CP--GPGR-VA---------KIGDFGMARDI-------------Y---R--ASYY------------RKGGCAMLPVKWMPPEAFM-----EGI-FTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK---SNQEVLEFV----TS----GGR---MDPPKNCP--------------GPVYR-IMTQCWQHQPEDRPN-----FAIILER--I-----
---V-ALGKTLGEGEFGAV---MEGQLN--------------QDDSIL---KVAV-KTM---K-I-AICT-RSE-LE-DFL-S----EAVCMKEF-DHPNVMRLIGVCF--QGSERESFPAPVVILPFMKHGDLHSFLL----YSRL---------------------------------------------------------------------------------------------GDQP-VYL---PTQMLVKFMADIASGMEYLST--K--R---FIHRDLAARNCMLN-E-----NM-SV---------CVADFGLSKKI-------------Y---N--GDYY------------RQGRIAKMPVKWIAIESLA-----DRV-YTSKSDVWSFGVTMWEIATRGQ-TP---------------YPGV---ENSEIYDYL----RQ----GNR---LKQPADCL--------------DGLYA-LMSRCWELNPQDRPS-----FTELREDL-------
---L-RLVRKLGSGQFGEV---WMGYYK-----------------NNM---KVAI-KTL---K-E--GTM-SP---E-AFL-G----EANVMKAL-QHERLVRLYAVVT---KEP------IYIVTEYMARGCLLDFLK----TD-------------------------------------------------------------------------------------------------EG-SRL---SLPRLIDMSAQIAEGMAYIER--M--N---SIHRDLRAANILVS-E-----AL-CC---------KIADFGLARII--------------------DSEY------------TAQEGAKFPIKWTAPEAIH-----FGV-FTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM---SNPEVIRNL----ER----GYR---MPRPDTCP--------------PELYRGVIAECWRSRPEERPT-----FEFLQSV--L-----
----ITLLKELGSGQFGVV---QLGKWK-----------------GQY---DVAV-KMI---K-E--GSM-SE---D-EFF-Q----EAQTMMKL-SHPKLVKFYGVCS--KEYP------IYIVTEYISNGCLLNYLR----SH--------------------------------------------------------------------------------------------------G-KGL---EPSQLLEMCYDVCEGMAFLES--H--Q---FIHRDLAARNCLVD-R-----DL-CV---------KVSDFGMTRYV-----------------L--DDQY------------VSSVGTKFPVKWSAPEVFH-----YFK-YSSKSDVWAFGILMWEVFSLGK-QP---------------YDLY---DNSQVVLKV----SQ----GHR---LYRPHLAS--------------DTIYQ-IMYSCWHELPEKRPT-----FQQLLSS--I-----
----LTFLKELGTGQFGVV---KYGKWR-----------------GQY---DVAI-KMI---K-E--GSM-SE---D-EFI-E----EAKVMMNL-SHEKLVQLYGVCT--KQRP------IFIITEYMANGCLLNYLR----EM--------------------------------------------------------------------------------------------------R-HRF---QTQQLLEMCKDVCEAMEYLES--K--Q---FLHRDLAARNCLVN-D-----QG-VV---------KVSDFGLSRYV-----------------L--DDEY------------TSSVGSKFPVRWSPPEVLM-----YSK-FSSKSDIWAFGVLMWEIYSLGK-MP---------------YERF---TNSETAEHI----AQ----GLR---LYRPHLAS--------------EKVYT-IMYSCWHEKADERPT-----FKILLSN--I-----
----LQFGKTLGAGAFGKV---VEATAFG-----------LGKEDAVL---KVAV-KML---K-S--TAH-ADE-KE-ALM-S----ELKIMSHLGQHENIVNLLGACT--HGGP------VLVITEYCCYGDLLNFLR----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDG-RPL---ELRDLLHFSSQVAQGMAFLAS--K--N---CIHRDVAARNVLLT-N-----GH-VA---------KIGDFGLARDI-------------M---N--DSNY------------IVKGNARLPVKWMAPESIF-----DCV-YTVQSDVWSYGILLWEIFSLGL-NP---------------YPGI-L-VNSKFYKLV----KD----GYQ---MAQPAFAP--------------KNIYS-IMQACWALEPTHRPT-----FQQICSFL-------
----LKLLQTIGKGEFGDV---MLGDYR------------------GN---KVAV-KCI---K-N--DAT-AQ-----AFL-A----EASVMTQL-RHSNLVQLLGVIV-EEKGG------LYIVTEYMAKGSLVDYLR----SR-------------------------------------------------------------------------------------------------GR-SVL---GGDCLLKFSLDVCEAMEYLEG--N--N---FVHRDLAARNVLVS-E-----DN-VA---------KVSDFGLTKEA-----------------------S------------STQDTGKLPVKWTAPEALR-----EKK-FSTKSDVWSFGILLWEIYSFGR-VP---------------YPRI---PLKDVVPRV----EK----GYK---MDAPDGCP--------------PAVYE-VMKNCWHLDAAMRPS-----FLQLREQL-------
----LRFKEKLGEGQFGEV---HLCEVDSPQDLVSLDFPLNVRKGHPL---LVAV-KIL---R-P--DAT-KNA-RN-DFL-K----EVKIMSRL-KDPNIIRLLGVCV--QDDP------LCMITDYMENGDLNQFLS----AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQG-PTI---SYPMLLHVAAQIASGMRYLAT--L--N---FVHRDLATRNCLVG-E-----NF-TI---------KIADFGMSRNL-------------Y---A--GDYY------------RVQGRAVLPIRWMAWECIL-----MGK-FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL---TDEQVIENAGEFFRD----QGRQVYLSRPPACP--------------QGLYE-LMLRCWSRESEQRPP-----FSQLHRFL-------
----LTFKEKLGEGQFGEV---HLCEVEGMEKFKDKDFALDVSANQPV---LVAV-KML---R-A--DAN-KNA-RN-DFL-K----EIKIMSRL-KDPNIIHLLAVCI--TDDP------LCMITEYMENGDLNQFLS----RHEPPN-----------------------------------------------------------------------------------------SSSSDV-RTV---SYTNLKFMATQIASGMKYLSS--L--N---FVHRDLATRNCLVG-K-----NY-TI---------KIADFGMSRNL-------------Y---S--GDYY------------RIQGRAVLPIRWMSWESIL-----LGK-FTTASDVWAFGVTLWETFTFCQEQP---------------YSQL---SDEQVIENT----GEFFRDQGRQTYLPQPAICP--------------DSVYK-LMLSCWRRDTKNRPS-----FQEIHL---LL----
---F-KKIKVLGSGAFGTV---YKGLWIP------------EGEKVKI---PVAI-KEL---R-E--ATS-PKA-NK-EIL-D----EAYVMASV-DNPHVCRLLGICL---TST------VQLITQLMPFGCLLDYVR----EH--------------------------------------------------------------------------------------------------K-DNI---GSQYLLNWCVQIAKGMNYLED--R--R---LVHRDLAARNVLVK-T-----PQ-HV---------KITDFGLAKLL-------------G---A--EEKE------------YHAEGGKVPIKWMALESIL-----HRI-YTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI---PASEISSIL----EK----GER---LPQPPICT--------------IDVYM-IMVKCWMIDADSRPK-----FRELI----IEF---
--LM--VDTVIGEGEFGEV---YRGTLR-------------LPSQDCK---TVAI-KTL---K-D--TSP-GGQ-WW-NFL-R----EATIMGQF-SHPHILHLEGVVT--KRKP------IMIITEFMENGALDAFLR----ER--------------------------------------------------------------------------------------------------E-DQL---VPGQLVAMLQGIASGMNYLSN--H--N---YVHRDLAARNILVN-Q-----NL-CC---------KVSDFGLTRLL-------------D---D--FDGT------------YETQGGKIPIRWTAPEAIA-----HRI-FTTASDVWSFGIVMWEVLSFGD-KP---------------YGEM---SNQEVMKSI----ED----GYR---LPPPVDCP--------------APLYE-LMKNCWAYDRARRPH-----FQKLQAHL-------
---I-SIDKVVGAGEFGEV---CSGRLK-------------LPSKKEI---SVAI-KTL---K-V--GYT-EKQ-RR-DFL-G----EASIMGQF-DHPNIIRLEGVVT--KSKP------VMIVTEYMENGSLDSFLR----KH--------------------------------------------------------------------------------------------------D-AQF---TVIQLVGMLRGIASGMKYLSD--M--G---YVHRDLAARNILIN-S-----NL-VC---------KVSDFGLSRVL-------------E---D--DPEA-----------AYTTRGGKIPIRWTSPEAIA-----YRK-FTSASDVWSYGIVLWEVMSYGE-RP---------------YWEM---SNQDVIKAV----DE----GYR---LPPPMDCP--------------AALYQ-LMLDCWQKDRNNRPK-----FEQIVSIL-------
---V-KIEEVIGAGEFGEV---YKGRLK-------------LPGKREI---YVAI-KTL---K-A--GYS-EKQ-RR-DFL-S----EASIMGQF-DHPNIIRLEGVVT--KSRP------VMIITEFMENGALDSFLR----QN--------------------------------------------------------------------------------------------------D-GQF---TVIQLVGMLRGIAAGMKYLAE--M--N---YVHRDLAARNILVN-S-----NL-VC---------KVSDFGLSRYLQ----------DDT---S--DPTY------------TSSLGGKIPVRWTAPEAIA-----YRK-FTSASDVWSYGIVMWEVMSFGE-RP---------------YWDM---SNQDVINAI----EQ----DYR---LPPPMDCP--------------AALHQ-LMLDCWQKDRNSRPR-----FAEIVNTL-------
---V-KIEQVIGAGEFGEV---CSGHLK-------------LPGKREI---FVAI-KTL---K-S--GYT-EKQ-RR-DFL-S----EASIMGQF-DHPNVIHLEGVVT--KSTP------VMIITEFMENGSLDSFLR----QN--------------------------------------------------------------------------------------------------D-GQF---TVIQLVGMLRGIAAGMKYLAD--M--N---YVHRDLAARNILVN-S-----NL-VC---------KVSDFGLSRFLE----------DDT---S--DPTY------------TSALGGKIPIRWTAPEAIQ-----YRK-FTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM---TNQDVINAI----EQ----DYR---LPPPMDCP--------------SALHQ-LMLDCWQKDRNHRPK-----FGQIVNTL-------
---V-KIEEVIGAGEFGEV---CRGRLK-------------QPGRREV---FVAI-KTL---K-V--GYT-ERQ-RR-DFL-S----EASIMGQF-DHPNIIRLEGVVT--KSRP------VMILTEFMENCALDSFLR----LN--------------------------------------------------------------------------------------------------D-GQF---TVIQLVGMLRGIAAGMKYLSE--M--N---YVHRDLAARNILVN-S-----NL-VC---------KVSDFGLSRFLE----------DDP---S--DPTY------------TSSLGGKIPIRWTAPEAIA-----YRK-FTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM---SNQDVINAV----EQ----DYR---LPPPMDCP--------------TALHQ-LMLDCWVRDRNLRPK-----FSQIVNTL-------
---V-KIEEVIGAGEFGEV---CRGRLK-------------APGKKES---CVAI-KTL---K-G--GYT-ERQ-RR-EFL-S----EASIMGQF-EHPNIIRLEGVVT--NSMP------VMILTEFMENGALDSFLR----LN--------------------------------------------------------------------------------------------------D-GQF---TVIQLVGMLRGIASGMRYLAE--M--S---YVHRDLAARNILVN-S-----NL-VC---------KVSDFGLSRFLE----------ENS---S--DPTY------------TSSLGGKIPIRWTAPEAIA-----FRK-FTSASDAWSYGIVMWEVMSFGE-RP---------------YWDM---SNQDVINAI----EQ----DYR---LPPPPDCP--------------TSLHQ-LMLDCWQKDRNARPR-----FPQVVSAL-------
----IKIEEVIGTGSFGEV---RQGRLQ-------------PRGRREQ---TVAI-QAL---W-A--GGA-ESL-QM-TFL-G----RAAVLGQF-QHPNILRLEGVVT--KSRP------LMVLTEFMELGPLDSFLR----QR--------------------------------------------------------------------------------------------------E-GQF---SSLQLVAMQRGVAAAMQYLSS--F--A---FVHRSLSAHSVLVN-S-----HL-VC---------KVARLGHSPQG-----------------------------------------PSCLLRWAAPEVIA-----HGK-HTTSSDVWSFGILMWEVMSYGE-RP---------------YWDM---SEQEVLNAI----EQ----EFR---LPPPPGCP--------------PGLHL-LMLDTWQKDRARRPH-----FDQLVA---AF----
---L-RKVKVLGSGAFGTV---YKGIWIP------------DGENVKI---PVAI-KVL---R-E--NTS-PKA-NK-EIL-D----EAYVMAGV-GSPYVSRLLGICL---TST------VQLVTQLMPYGCLLDHVR----EN--------------------------------------------------------------------------------------------------R-GRL---GSQDLLNWCMQIAKGMSYLED--V--R---LVHRDLAARNVLVK-S-----PN-HV---------KITDFGLARLL-------------D---I--DETE------------YHADGGKVPIKWMALESIL-----RRR-FTHQSDVWSYGVTVWELMTFGA-KP---------------YDGI---PAREIPDLL----EK----GER---LPQPPICT--------------IDVYM-IMVKCWMIDSECRPR-----FRELVSE--F-----
---L-KRVKVLGSGAFGTV---YKGIWVP------------EGETVKI---PVAI-KIL---N-E--TTG-PKA-NV-EFM-D----EALIMASM-DHPHLVRLLGVCL---SPT------IQLVTQLMPHGCLLEYVH----EH--------------------------------------------------------------------------------------------------K-DNI---GSQLLLNWCVQIAKGMMYLEE--R--R---LVHRDLAARNVLVK-S-----PN-HV---------KITDFGLARLL-------------E---G--DEKE------------YNADGGKMPIKWMALECIH-----YRK-FTHQSDVWSYGVTIWELMTFGG-KP---------------YDGI---PTREIPDLL----EK----GER---LPQPPICT--------------IDVYM-VMVKCWMIDADSRPK-----FKELAAE--F-----
--VI--LGELLGKGNFGEV---YKGTLK-----------------DKT---SVAV-KTC---K-E--DLP-QEL-KI-KFL-Q----EAKILKQY-DHPNIVKLIGVCT--QRQP------VYIIMELVSGGDFLTFLR----RK--------------------------------------------------------------------------------------------------K-DEL---KLKQLVKFSLDAAAGMLYLES--K--N---CIHRDLAARNCLVG-E-----NN-VL---------KISDFGMSRQE-----------------D--GGVY------------SSSGLKQIPIKWTAPEALN-----YGR-YSSESDVWSFGILLWETFSLGV-CP---------------YPGM---TNQQAREQV----ER----GYR---MSAPQHCP--------------EDISK-IMMKCWDYKPENRPK-----FSELQKEL-------
---L-VLGEQIGRGNFGEV---FSGRLR----------------ADNT---LVAV-KSC---R-E--TLP-PDL-KA-KFL-Q----EARILKQY-SHPNIVRLIGVCT--QKQP------IYIVMELVQGGDFLTFLR----TE--------------------------------------------------------------------------------------------------G-ARL---RVKTLLQMVGDAAAGMEYLES--K--C---CIHRDLAARNCLVT-E-----KN-VL---------KISDFGMSREE-------------A---D--GVYA------------ASGGLRQVPVKWTAPEALN-----YGR-YSSESDVWSFGILLWETFSLGA-SP---------------YPNL---SNQQTREFV----EK----GGR---LPCPELCP--------------DAVFR-LMEQCWAYEPGQRPS-----FSTIYQEL-------
---L-VLGKPLGEGCFGQV---VLAEAIGL---------DKDKPNRVT---KVAV-KML---K-S--DAT-EKD-LS-DLI-S----EMEMMKMIGKHKNIINLLGACT--QDGP------LYVIVEYASKGNLREYLQ----ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPE-EQL---SSKDLVSCAYQVARGMEYLAS--K--K---CIHRDLAARNVLVT-E-----DN-VM---------KIADFGLARDI-------------H---H--IDYY------------KKTTNGRLPVKWMAPEALF-----DRI-YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV---PVEELFKLL----KE----GHR---MDKPSNCT--------------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL-------
----LTLGKPLGEGCFGQV---VMAEAVGI---------DKDKPKEAV---TVAV-KML---K-D--DAT-EKD-LS-DLV-S----EMEMMKMIGKHKNIINLLGACT--QDGP------LYVIVEYASKGNLREYLR----ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPE-EQM---TFKDLVSCTYQLARGMEYLAS--Q--K---CIHRDLAARNVLVT-E-----NN-VM---------KIADFGLARDI-------------N---N--IDYY------------KKTTNGRLPVKWMAPEALF-----DRV-YTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI---PVEELFKLL----KE----GHR---MDKPANCT--------------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL-------
----LTLGKPLGEGCFGQV---VMAEAIGI---------DKDRAAKPV---TVAV-KML---K-D--DAT-DKD-LS-DLV-S----EMEMMKMIGKHKNIINLLGACT--QGGP------LYVLVEYAAKGNLREFLR----ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPE-EQL---TFKDLVSCAYQVARGMEYLAS--Q--K---CIHRDLAARNVLVT-E-----DN-VM---------KIADFGLARDV-------------H---N--LDYY------------KKTTNGRLPVKWMAPEALF-----DRV-YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI---PVEELFKLL----KE----GHR---MDKPANCT--------------HDLYM-IMRECWHAAPSQRPT-----FKQLVEDL-------
---L-VLGKPLGEGCFGQV---VRAEAFGM---------DPARPDQAS---TVAV-KML---K-D--NAS-DKD-LA-DLV-S----EMEVMKLIGRHKNIINLLGVCT--QEGP------LYVIVECAAKGNLREFLR----ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSE-GPL---SFPVLVSCAYQVARGMQYLES--R--K---CIHRDLAARNVLVT-E-----DN-VM---------KIADFGLARGV-------------H---H--IDYY------------KKTSNGRLPVKWMAPEALF-----DRV-YTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI---PVEELFSLL----RE----GHR---MDRPPHCP--------------PELYG-LMRECWHAAPSQRPT-----FKQLVEAL-------
----ITLERRLGTGCFGDV---WLGTWN-----------------GST---KVAV-KTL---K-P--GTM-SP---K-AFL-E----EAQVMKLL-RHDKLVQLYAVVS---EEP------IYIVTEFMCHGSLLDFLK----NP-------------------------------------------------------------------------------------------------EG-QDL---RLPQLVDMAAQVAEGMAYMER--M--N---YIHRDLRAANILVG-E-----RL-AC---------KIADFGLARLI-----------------K--DDEY------------NPCQGSKFPIKWTAPEAAL-----FGR-FTIKSDVWSFGILLTELITKGR-IP---------------YPGM---NKREVLEQV----EQ----GYH---MPCPPGCP--------------ASLYE-AMEQTWRLDPEERPT-----FEYLQSFL-------
----LHLGRVLGYGAFGKV---VEASAFG-----------IHKGSSCD---TVAV-KML---K-E--GAT-ASE-HR-ALM-S----ELKILIHIGNHLNVVNLLGACT-KPQGP------LMVIVEFCKYGNLSNFLR----AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWL-SPL---TMEDLVCYSFQVARGMEFLAS--R--K---CIHRDLAARNILLS-E-----SD-VV---------KICDFGLARDI-------------Y---K--DPDY------------VRKGSARLPLKWMAPESIF-----DKV-YTTQSDVWSFGVLLWEIFSLGA-SP---------------YPGV-Q-INEEFCQRL----RD----GTR---MRAPELAT--------------PAIRR-IMLNCWSGDPKARPA-----FSELVEIL-------
----LQLIKRLGNGQFGEV---WMGTWN-----------------GNT---KVAI-KTL---K-P--GTM-SP---E-SFL-E----EAQIMKKL-KHDKLVQLYAVVS---EEP------IYIVTEYMNKGSLLDFLK----DG-------------------------------------------------------------------------------------------------EG-RAL---KLPNLVDMAAQVAAGMAYIER--M--N---YIHRDLRSANILVG-N-----GL-IC---------KIADFGLARLI-----------------E--DNEY------------TARQGAKFPIKWTAPEAAL-----YGR-FTIKSDVWSFGILLTELVTKGR-VP---------------YPGM---NNREVLEQV----ER----GYR---MPCPQDCP--------------ISLHE-LMIHCWKKDPEERPT-----FEYLQSFL-------
----LKLEKKLGAGQFGEV---WMATYN-----------------KHT---KVAV-KTM---K-P--GSM-SV---E-AFL-A----EANVMKTL-QHDKLVKLHAVVT---KEP------IYIITEFMAKGSLLDFLK----SD-------------------------------------------------------------------------------------------------EG-SKQ---PLPKLIDFSAQIAEGMAFIEQ--R--N---YIHRDLRAANILVS-A-----SL-VC---------KIADFGLARVI-----------------E--DNEY------------TAREGAKFPIKWTAPEAIN-----FGS-FTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM---SNPEVIRAL----ER----GYR---MPRPENCP--------------EELYN-IMMRCWKNRPEERPT-----FEYIQSV--L-----
----ITMSRELGQGSFGMV---YEGVAKG-----------VVKDEPET---RVAI-KTV---N-E--AAS-MRE-RI-EFL-N----EASVMKEF-NCHHVVRLLGVVS--QGQP------TLVIMELMTRGDLKSYLR----SLRPEM-----------------------------------------------------------------------------------------ENNPVL-APP---SLSKMIQMAGEIADGMAYLNA--N--K---FVHRDLAARNCMVA-E-----DF-TV---------KIGDFGMTRDI-------------Y---E--TDYY------------RKGGKGLLPVRWMSPESLK-----DGV-FTTYSDVWSFGVVLWEIATLAE-QP---------------YQGL---SNEQVLRFV----ME----GGL---LDKPDNCP--------------DMLFE-LMRMCWQYNPKMRPS-----FLEIISS--I-----
----ITLLRELGQGSFGMV---YEGNARD-----------IIKGEAET---RVAV-KTV---N-E--SAS-LRE-RI-EFL-N----EASVMKGF-TCHHVVRLLGVVS--KGQP------TLVVMELMAHGDLKSYLR----SLRPEA-----------------------------------------------------------------------------------------ENNPGR-PPP---TLQEMIQMAAEIADGMAYLNA--K--K---FVHRDLAARNCMVA-H-----DF-TV---------KIGDFGMTRDI-------------Y---E--TDYY------------RKGGKGLLPVRWMAPESLK-----DGV-FTTSSDMWSFGVVLWEITSLAE-QP---------------YQGL---SNEQVLKFV----MD----GGY---LDQPDNCP--------------ERVTD-LMRMCWQFNPKMRPT-----FLEIVNLL-------
---I-SIIRELGQGSFGMV---YEGLARG-----------LEAGEEST---PVAL-KTV---N-E--LAS-PRE-CI-EFL-K----EASVMKAF-KCHHVVRLLGVVS--QGQP------TLVIMELMTRGDLKSHLR----SLRPEA-----------------------------------------------------------------------------------------ENNPGL-PQP---ALGEMIQMAGEIADGMAYLAA--N--K---FVHRDLAARNCMVS-Q-----DF-TV---------KIGDFGMTRDV-------------Y---E--TDYY------------RKGGKGLLPVRWMAPESLK-----DGI-FTTHSDVWSFGVVLWEIVTLAE-QP---------------YQGL---SNEQVLKFV----MD----GGV---LEELEGCP--------------LQLQE-LMSRCWQPNPRLRPS-----FTHILD---SI----
-VGG----NKMGEGGFGVV---YKGYVN----------------NTT-----VAV-KKL---AAM--VDITTE---ELKQQFD---QEIKVMAKC-QHENLVELLGFSS--DGDD------LCLVYVYMPNGSLLDRLSCLDGTP-----------------------------------------------------------------------------------------------------PL---SWHMRCKIAQGAANGINFLHE--N--H---HIHRDIKSANILLD-E-----AF-TA---------KISDFGLARASE---------------KFAQTVMT------------SR---IVGTTAYMAPEALR------GE-ITPKSDIYSFGVVLLEIIT-GL-PA---------------VDEH---REPQLLLDI----KE----EIE---DEEKTIEDYIDKKMNDADSTSVEAMYS-VASQCLHEKKNKRPD-----IKKVQQ----LLQ--
----LTFVQEIGSGQFGLV---HLGYWL-----------------NKD---KVAI-KTI---R-E--GAM-SE---E-DFI-E----EAEVMMKL-SHPKLVQLYGVCL--EQAP------ICLVFEFMEHGCLSDYLR----TQ--------------------------------------------------------------------------------------------------R-GLF---AAETLLGMCLDVCEGMAYLEE--A--C---VIHRDLAARNCLVG-E-----NQ-VI---------KVSDFGMTRFV-----------------L--DDQY------------TSSTGTKFPVKWASPEVFS-----FSR-YSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR---SNSEVVEDI----ST----GFR---LYKPRLAS--------------THVYQ-IMNHCWKERPEDRPA-----FSRLLRQL-------
---L-KRIRDLGEGHFGKV---ELCRYDP------------EGDNTGE---QVAV-KSL---K-P--ESG-GNH-IA-DLK-K----EIEILRNL-YHENIVKYKGICT-ED-GGN----GIKLIMEFLPSGSLKEYLP----KN--------------------------------------------------------------------------------------------------K-NKI---NLKQQLKYAVQICKGMDYLGS--R--Q---YVHRDLAARNVLVE-S-----EH-QV---------KIGDFGLTKAI------------ET---D--KEYY------------TVKDDRDSPVFWYAPECLM-----QSK-FYIASDVWSFGVTLHELLTYCD-SDSSPMALF-LKMIGPTHGQM---TVTRLVNTL----KE----GKR---LPCPPNCP--------------DEVYQ-LMRKCWEFQPSNRTS-----FQNLIE---GF----
----LKFLQQLGKGNFGSV---EMCRYDP------------LQDNTGE---VVAV-KKL---Q-H--STE--EH-LR-DFE-R----EIEILKSL-QHDNIVKYKGVCYSAGRRN------LKLIMEYLPYGSLRDYLQ----KH--------------------------------------------------------------------------------------------------K-ERI---DHIKLLQYTSQICKGMEYLGT--K--R---YIHRDLATRNILVE-N-----EN-RV---------KIGDFGLTKVL------------PQ---D--KEYY------------KVKEPGESPIFWYAPESLT-----ESK-FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM---IVFHLIELL----KN----NGR---LPRPDGCP--------------DEIYM-IMTECWNNNVNQRPS-----FRDLA----LRV---
---L-KYISQLGKGNFGSV---ELCRYDP------------LGDNTGA---LVAV-KQL---Q-H--SGP-DQ--QR-DFQ-R----EIQILKAL-HSDFIVKYRGVSYGPGRQS------LRLVMEYLPSGCLRDFLQ----RH--------------------------------------------------------------------------------------------------R-ARL---DASRLLLYSSQICKGMEYLGS--R--R---CVHRDLAARNILVE-S-----EA-HV---------KIADFGLAKLL------------PL---D--KDYY------------VVREPGQSPIFWYAPESLS-----DNI-FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDV-P-ALCRLLELL----EE----GQR---LPAPPACP--------------AEVHE-LMKLCWAPSPQDRPS-----FSALGP---QL----
----LKLGKPLGRGAFGQV---IEADAFG-----------IDKTATCR---TVAV-KML---K-E--GAT-HSE-HR-ALM-S----ELKILIHIGHHLNVVNLLGACT-KPGGP------LMVIVEFCKFGNLSTYLR----SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYK-DFL---TLEHLICYSFQVAKGMEFLAS--R--K---CIHRDLAARNILLS-E-----KN-VV---------KICDFGLARDI-------------Y---K--DPDY------------VRKGDARLPLKWMAPETIF-----DRV-YTIQSDVWSFGVLLWEIFSLGA-SP---------------YPGV-K-IDEEFCRRL----KE----GTR---MRAPDYTT--------------PEMYQ-TMLDCWHGEPSQRPT-----FSELVEHL-------
----LSFGKTLGAGAFGKV---VEATAYG-----------LIKSDAAM---TVAV-KML---K-P--SAH-LTE-RE-ALM-S----ELKVLSYLGNHMNIVNLLGACT--IGGP------TLVITEYCCYGDLLNFLR----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDE-LAL---DLEDLLSFSYQVAKGMAFLAS--K--N---CIHRDLAARNILLT-H-----GR-IT---------KICDFGLARDI-------------K---N--DSNY------------VVKGNARLPVKWMAPESIF-----NCV-YTFESDVWSYGIFLWELFSLGS-SP---------------YPGM-P-VDSKFYKMI----KE----GFR---MLSPEHAP--------------AEMYD-IMKTCWDADPLKRPT-----FKQIVQL--I-----
----LKLVERLGAGQFGEV---WMGYYN-----------------GHT---KVAV-KSL---K-Q--GSM-SP---D-AFL-A----EANLMKQL-QHQRLVRLYAVVT---QEP------IYIITEYMENGSLVDFLK----TP-------------------------------------------------------------------------------------------------SG-IKL---TINKLLDMAAQIAEGMAFIEE--R--N---YIHRDLRAANILVS-D-----TL-SC---------KIADFGLARLI-----------------E--DNEY------------TAREGAKFPIKWTAPEAIN-----YGT-FTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM---TNPEVIQNL----ER----GYR---MVRPDNCP--------------EELYQ-LMRLCWKERPEDRPT-----FDYLRSV--L-----
--LI--HGEVLGKGCFGQA---IKVTHR----------------ETGE---VMVM-KEL---I----RFD-EET-QR-TFL-K----EVKVMRCL-EHPNVLKFIGVLY--KDKR------LNFITEYIKGGTLRGIIK----SM--------------------------------------------------------------------------------------------------D-SQY---PWSQRVSFAKDIASGMAYLHS--M--N---IIHRDLNSHNCLVR-E-----NK-NV---------VVADFGLARLM-------------V---D--EKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMIN-----GRS-YDEKVDVFSFGIVLCEIIGRVN-AD---------------PDYL-P-RTMDFGLNV----RG----FLD---RYCPPNCP--------------PSFFP-ITVRCCDLDPEKRPS-----FVKLEH---WL----
--LI--HGEVLGKGFFGQA---IKVTHK-----------------ATG---KVMVMKEL-----I--RCD-EET-QK-TFL-T----EVKVMRSL-DHPNVLKFIGVLY--KDKK------LNLLTEYIEGGTLKDFLR----SM----------------------------------------------------------------------------------------------------DPF---PWQQKVRFAKGIASGMAYLHS--M--C---IIHRDLNSHNCLIK-L-----DK-TV---------VVADFGLSRLIVEERKRAPMEKATT---------KKRTL---RKNDRKKRYTVVGNPYWMAPEMLN-----GKS-YDETVDIFSFGIVLCEIIGQVY-AD---------------PDCL-P-RTLDFGLNV----KL----FWE---KFVPTDCP--------------PAFFP-LAAICCRLEPESRPA-----FSKLED---SF----
---V-TLLRALGHGAFGEV---YEGLVIG-----------LPGDSSPL---QVAI-KTL---P-E--LCS-PQD-EL-DFL-M----EALIISKF-RHQNIVRCVGLSL--RATP------RLILLELMSGGDMKSFLR----HSRP--------------------------------------------------------------------------------------------HLGQP-SPL---VMRDLLQLAQDIAQGCHYLEE--N--H---FIHRDIAARNCLLS-CA--GPSR-VA---------KIGDFGMARDI-------------Y---R--ASYY------------RRGDRALLPVKWMPPEAFL-----EGI-FTSKTDSWSFGVLLWEIFSLGY-MP---------------YPGR---TNQEVLDFV----VG----GGR---MDPPRGCP--------------GPVYR-IMTQCWQHEPELRPS-----FASILERL-------
-ERV-----VLGKGTYGIV---YAGRDL----------------SNQV---RIAI-KEI---PER--DSRYSQ---P-LH--E----EIALHKYL-KHRNIVQYLGSVS--ENGY------IKIFMEQVPGGSLSALLR--SKWG-----------------------------------------------------------------------------------------------------PM---KEPTIKFYTKQILEGLKYLHE--N--Q---IVHRDIKGDNVLVNTY-----SG-VV---------KISDFGTSKRL-----------------AGVNPCT------------ET---FTGTLQYMAPEIID---QGPRG-YGAPADIWSLGCTIIEMAT-SK-PP---------------FHEL-----GEPQAAM----FK----VGM---FKIHPEIPEALS----------AEARA-FILSCFEPDPHKRAT-----TAELLREGF-L----
-ERL-----VLGKGTYGVV---YAGRDR----------------HTRV---RIAI-KEI---PER--DSRFSQ---P-LH--E----EIALHRRL-RHKNIVRYLGSAS--QGGY------LKIFMEEVPGGSLSSLLR--SVWG-----------------------------------------------------------------------------------------------------PLK-DNESTISFYTRQILQGLGYLHD--N--H---IVHRDIKGDNVLINTF-----SG-LL---------KISDFGTSKRL-----------------AGITPCT------------ET---FTGTLQYMAPEIID---QGPRG-YGKAADIWSLGCTVIEMAT-GR-PP---------------FHEL-----GSPQAAM----FQ----VGM---YKVHPPMPSSLS----------AEAQA-FLLRTFEPDPRLRAS-----AQTLLGDPFL-----
----IEVEEVVGRGAFGVV---CKAKWR------------------AK---DVAI-KQI---E------S-ESE-RK-AFI-V----ELRQLSRV-NHPNIVKLYGACL----NP------VCLVMEYAEGGSLYNVLH----GA-------------------------------------------------------------------------------------------------EPLPYY---TAAHAMSWCLQCSQGVAYLHS--M--QPKALIHRDLKPPNLLLV-A-----GGTVL---------KICDFGTACDI-----------------------Q------------THMTNNKGSAAWMAPEVFE-----GSN-YSEKCDVFSWGIILWEVITR-R-KP---------------FDEIGG-PAFRIMWAV----HN----GTR---PPLIKNLP--------------KPIES-LMTRCWSKDPSQRPS-----MEEIVKI--M-----
----LTLGAQIGEGEFGAV---LQGEYL------------------GQ---KVAV-KNI---K-C--DVT-AQ-----AFL-D----ETAVMTKM-QHENLVRLLGVIL---HQG------LYIVMEHVSKGNLVNFLR----TR-------------------------------------------------------------------------------------------------GR-ALV---NTAQLLQFSLHVAEGMEYLES--K--K---LVHRDLAARNILVS-E-----DL-VA---------KVSDFGLAKAE-----------------------R------------KGLDSSRLPVKWTAPEALK-----HGK-FTSKSDVWSFGVLLWEVFSYGR-AP---------------YPKM---SLKEVSEAV----EK----GYR---MEPPEGCP--------------GPVHV-LMSSCWEAEPARRPP-----FRKLAEKL-------
---L-ILGKILGEGEFGSV---MEGNLK-------------QEDGTSL---KVAV-KTM---KLD--NSS-QRE-IE-EFL-S----EAACMKDF-SHPNVIRLLGVCI--EMSSQG-IPKPMVILPFMKYGDLHTYLL----YSRL---------------------------------------------------------------------------------------------ETGP-KHI---PLQTLLKFMVDIALGMEYLSN--R--N---FLHRDLAARNCMLR-D-----DM-TV---------CVADFGLSKKI-------------Y---S--GDYY------------RQGRIAKMPVKWIAIESLA-----DRV-YTSKSDVWAFGVTMWEIATRGM-TP---------------YPGV---QNHEMYDYL----LH----GHR---LKQPEDCL--------------DELYE-IMYSCWRTDPLDRPT-----FSVLRLQ--L-----
----VHFNEVIGRGHFGCV---YHGTLL-------------DNDGKKI---HCAV-KSL---N-R--ITD-IGE-VS-QFL-T----EGIIMKDF-SHPNVLSLLGICL-RSEGS------PLVVLPYMKHGDLRNFIR----NE--------------------------------------------------------------------------------------------------T-HNP---TVKDLIGFGLQVAKGMKYLAS--K--K---FVHRDLAARNCMLD-E-----KF-TV---------KVADFGLARDM-------------Y---D--KEYYS----------VHNKTGAKLPVKWMALESLQ-----TQK-FTTKSDVWSFGVLLWELMTRGA-PP---------------YPDV---NTFDITVYL----LQ----GRR---LLQPEYCP--------------DPLYE-VMLKCWHPKAEMRPS-----FSELVSR--I-----
-THS---DRVIGKGHFGVV---YHGEYI-------------DQAQNRI---QCAI-KSL---S-R--ITE-MQQ-VE-AFL-R----EGLLMRGL-NHPNVLALIGIML-PPEGL------PHVLLPYMCHGDLLQFIR----SP--------------------------------------------------------------------------------------------------Q-RNP---TVKDLISFGLQVARSMEYLAE--Q--K---FVHRDLAARNCMLD-E-----SF-TV---------KVADFGLARDI-------------L---D--REYYS----------VQQHRHARLPVKWMALESLQ-----TYR-FTTKSDVWSFGVLLWELLTRGA-PP---------------YRHI---DPFDLTHFL----AQ----GRR---LPQPEYCP--------------DSLYQ-VMQQCWEADPAVRPT-----FRVLV----GEV---
---I-EYVRDIGEGAFGRV---FQARAPG-----------LLPYEPFT---MVAV-KML---K-E--EAS-ADM-QA-DFQ-R----EAALMAEF-DNPNIVKLLGVCA--VGKP------MCLLFEYMAYGDLNEFLR----SMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGP-PPL---SCAEQLCIARQVAAGMAYLSE--R--K---FVHRDLATRNCLVG-E-----NM-VV---------KIADFGLSRNI-------------Y---S--ADYY------------KANENDAIPIRWMPPESIF-----YNR-YTTESDVWAYGVVLWEIFSYGL-QP---------------YYGM---AHEEVIYYV----RD----GNI---LSCPENCP--------------VELYN-LMRLCWSKLPADRPS-----FTSIHRIL-------
--IV--LKWELGEGAFGKV---FLAECHN-----------LLPEQDKM---LVAV-KAL---K-E--ASE-SA--RQ-DFQ-R----EAELLTML-QHQHIVRFFGVCT--EGRP------LLMVFEYMRHGDLNRFLR----SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAP-GPL---GLGQLLAVASQVAAGMVYLAG--L--H---FVHRDLATRNCLVG-Q-----GL-VV---------KIGDFGMSRDI-------------Y---S--TDYY------------RVGGRTMLPIRWMPPESIL-----YRK-FTTESDVWSFGVVLWEIFTYGK-QP---------------WYQL---SNTEAIDCI----TQ----GRE---LERPRACP--------------PEVYA-IMRGCWQREPQQRHS-----IKDVHARL-------
---I-VLKRELGEGAFGKV---FLAECYN-----------LCPEQDKI---LVAV-KTL---K-D--ASD-NA--RK-DFH-R----EAELLTNL-QHEHIVKFYGVCV--EGDP------LIMVFEYMKHGDLNKFLR----AHGPDAV--------------------------------------------------------------------------------------LMAEGNPP-TEL---TQSQMLHIAQQIAAGMVYLAS--Q--H---FVHRDLATRNCLVG-E-----NL-LV---------KIGDFGMSRDV-------------Y---S--TDYY------------RVGGHTMLPIRWMPPESIM-----YRK-FTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL---SNNEVIECI----TQ----GRV---LQRPRTCP--------------QEVYE-LMLGCWQREPHMRKN-----IKGIHTL--L-----
DNFI-----KIGEGSTGIV---CIATVR----------------SSGK---LVAV-KKM---DLR--KQQRRE---L---LFN----EVVIMRDY-QHENVVEMYNSYL--VGDE------LWVVMEFLEGGALTDIVT----HT-----------------------------------------------------------------------------------------------------RM---NEEQIAAVCLAVLQALSVLHA--Q--G---VIHRDIKSDSILLT-H-----DG-RV---------KLSDFGFCAQV-----------------SKEVPRR------------KS---LVGTPYWMAPELIS-----RLP-YGPEVDIWSLGIMVIEMVD-GE-PP---------------YFNE---PPLKAMKMI----RD----NLP---PRLKNLHKVS------------PSLKG-FLDRLLVRDPAQRAT-----AAELLKHPFL-----
---L-VLGRVLGSGAFGKV---VEGTAYG-----------LSRSQPVM---KVAV-KML---K-P--TAR-SSE-KQ-ALM-S----ELKIMTHLGPHLNIVNLLGACT--KSGP------IYIITEYCFYGDLVNYLH----KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNS-EGL---TLLDLLSFTYQVARGMEFLAS--K--N---CVHRDLAARNVLLA-Q-----GK-IV---------KICDFGLARDI-------------M---H--DSNY------------VSKGSTFLPVKWMAPESIF-----DNL-YTTLSDVWSYGILLWEIFSLGG-TP---------------YPGM-M-VDSTFYNKI----KS----GYR---MAKPDHAT--------------SEVYE-IMVKCWNSEPEKRPS-----FYHLSE---IV----
---L-VLGRTLGSGAFGQV---VEATAHG-----------LSHSQATM---KVAV-KML---K-S--TAR-SSE-KQ-ALM-S----ELKIMSHLGPHLNVVNLLGACT--KGGP------IYIITEYCRYGDLVDYLH----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINES-PVL---SYMDLVGFSYQVANGMEFLAS--K--N---CVHRDLAARNVLIC-E-----GK-LV---------KICDFGLARDI-------------M---R--DSNY------------ISKGSTFLPLKWMAPESIF-----NSL-YTTLSDVWSFGILLWEIFTLGG-TP---------------YPEL-P-MNEQFYNAI----KR----GYR---MAQPAHAS--------------DEIYE-IMQKCWEEKFEIRPP-----FSQLVL---LL----
--YV--RGRFLGKGGFAKC---FEISDA----------------DTKE---VFAG-KIV---PKS--LLLKPH---Q-REKMS---MEISIHRSL-AHQHVVGFHGFFE--DNDF------VFVVLELCRRRSLLELHK---RRK-----------------------------------------------------------------------------------------------------AL---TEPEARYYLRQIVLGCQYLHR--N--R---VIHRDLKLGNLFLN-E-----DL-EV---------KIGDFGLATKV-----------------EYDGERK------------KT---LCGTPNYIAPEVLS-----KKG-HSFEVDVWSIGCIMYTLLV-GK-PP---------------FETS------CLKETY----LR----IKK---NEYSIPKHIN------------PVAAS-LIQKMLQTDPTARPT-----INELLNDEFF-----
----IELGRCIGEGQFGDV---HQGIYM-------------SPENPAL---AVAI-KTC---K-N--CTS-DSV-RE-KFL-Q----EALTMRQF-DHPHIVKLIGVIT---ENP------VWIIMELCTLGELRSFLQ----VR--------------------------------------------------------------------------------------------------K-YSL---DLASLILYAYQLSTALAYLES--K--R---FVHRDIAARNVLVS-S-----ND-CV---------KLGDFGLSRYM-----------------E--DSTY------------YKASKGKLPIKWMAPESIN-----FRR-FTSASDVWMFGVCMWEILMHGV-KP---------------FQGV---KNNDVIGRI----EN----GER---LPMPPNCP--------------PTLYS-LMTKCWAYDPSRRPR-----FTELKAQL-------
---V-VLNRILGEGFFGEV---YEGVYT-------------NHKGEKI---NVAV-KTC---K-K--DCT-LDN-KE-KFM-S----EAVIMKNL-DHPHIVKLIGIIE---EEP------TWIIMELYPYGELGHYLE----RN--------------------------------------------------------------------------------------------------K-NSL---KVLTLVLYSLQICKAMAYLES--I--N---CVHRDIAVRNILVA-S-----PE-CV---------KLGDFGLSRYI-----------------E--DEDY------------YKASVTRLPIKWMSPESIN-----FRR-FTTASDVWMFAVCMWEILSFGK-QP---------------FFWL---ENKDVIGVL----EK----GDR---LPKPDLCP--------------PVLYT-LMTRCWDYDPSDRPR-----FTELVCS--L-----
---F-TLCRKLGSGYFGEV---FEGLWK-----------------DRV---QVAI-KVI---S-R--DNL-LH--QQ-MLQ-S----EIQAMKKL-RHKHILALYAVVS--VGDP------VYIITELMAKGSLLELLR----DS-------------------------------------------------------------------------------------------------DE-KVL---PVSELLDIAWQVAEGMCYLES--Q--N---YIHRDLAARNILVG-E-----NT-LC---------KVGDFGLARLI--------------------KEDV------------YLSHDHNIPYKWTAPEALS-----RGH-YSTKSDVWSFGILLHEMFSRGQ-VP---------------YPGM---SNHEAFLRV----DA----GYR---MPCPLECP--------------PSVHK-LMLTCWCRDPEQRPC-----FKALRERL-------
---L-VLGKTLGEGEFGKV---VKATAFH-----------LKGRAGYT---TVAV-KML---K-E--NAS-PSE-LR-DLL-S----EFNVLKQV-NHPHVIKLYGACS--QDGP------LLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDE-RAL---TMGDLISFAWQISQGMQYLAE--M--K---LVHRDLAARNILVA-E-----GR-KM---------KISDFGLSRDV-------------Y---E--EDSY------------VKRSQGRIPVKWMAIESLF-----DHI-YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI---PPERLFNLL----KT----GHR---MERPDNCS--------------EEMYR-LMLQCWKQEPDKRPV-----FADISKDL-------
-LAD---LRYLSRGASGTV---SSARHA----------------DWRV---QVAV-KHL---HIH--TPLLDS---E-RKDVL---REAEILHKA-RFSYILPILGICN--EPEF------LGIVTEYMPNGSLNELLH---RKT-----------------------------------------------------------------------------------------------------EYPDVAWPLRFRILHEIALGVNYLHN--MTPP---LLHHDLKTQNILLD-N-----EF-HV---------KIADFGLSKWRMM------------SLSQSRSSKS------------AP---EGGTIIYMPPENYEP--GQKSR-ASIKHDIYSYAVITWEVLS-RK-QP---------------FEDVT-NPLQIMYSVS----QG----HRP---VINEESLPYDIPHR--------ARMIS-LIESGWAQNPDERPS-----FLKCL-----IEL--
FTGW----EKVGSGGFGQV---YKVRHV----------------HWKT---WLAI-KCS---PSL--HVDDRE---R-MELLE----EAKKMEMA-KFRYILPVYGIC----REP------VGLVMEYMETGSLEKLLA----SE-----------------------------------------------------------------------------------------------------PL---PWDLRFRIIHETAVGMNFLHC--MAPP---LLHLDLKPANILLD-A-----HY-HV---------KISDFGLAKCNG--------------LSHSHDLSM------------DG---LFGTIAYLPPERIR---EKSRL-FDTKHDVYSFAIVIWGVLT-QK-KP---------------FADE--KNILHIMVKV----VK----GHR---PELPPVCRARPRAC--------SHLIR-LMQRCWQGDPRVRPT-----FQ--------GNGLN
--LT--LRLLLGSGAFGEV---YEGTAVDI----------LGVGSGEI---KVAV-KTL---K-K--GST-DQE-KI-EFL-K----EAHLMSKF-NHPNILKQLGVCL--LNEP------QYIILELMEGGDLLTYLR----KARM--------------------------------------------------------------------------------------------ATFYG-PLL---TLVDLVDLCVDISKGCVYLER--M--H---FIHRDLAARNCLVS-VKDYTSPR-IV---------KIGDFGLARDI-------------Y---K--NDYY------------RKRGEGLLPVRWMAPESLM-----DGI-FTTQSDVWSFGILIWEILTLGH-QP---------------YPAH---SNLDVLNYV----QT----GGR---LEPPRNCP--------------DDLWN-LMTQCWAQEPDQRPT-----FHRIQDQL-------
----FELLKVLGQGSFGKVFLVRKVTRP----------------DSGH---LYAM-KVL---KKA--TLKVRD---R-VRTKM----ERDILADV-NHPFVVKLHYAFQ--TEGK------LYLILDFLRGGDLFTRLS---KEV-----------------------------------------------------------------------------------------------------MF---TEEDVKFYLAELALGLDHLHS--L--G---IIYRDLKPENILLD-E-----EG-HI---------KLTDFGLSKEA-----------------IDHEKKA------------YS---FCGTVEYMAPEVVN-----RQG-HSHSADWWSYGVLMFEMLT-GS-LP---------------FQGK------DRKETM----TL----ILK---AKLGMPQFLS------------TEAQS-LLRALFKRNPANRLGSGPDGAEEIKRHV--FY---
----FELLKVLGQGSFGKV---FLVKKI----------------SGSDARQLYAM-KVL---KKA--TLKVRD---R-VRTKM----ERDILVEV-NHPFIVKLHYAFQ--TEGK------LYLILDFLRGGDLFTRLS---KEV-----------------------------------------------------------------------------------------------------MF---TEEDVKFYLAELALALDHLHS--L--G---IIYRDLKPENILLD-E-----EG-HI---------KLTDFGLSKES-----------------IDHEKKA------------YS---FCGTVEYMAPEVVN-----RRG-HTQSADWWSFGVLMFEMLT-GT-LP---------------FQGK------DRKETM----TM----ILK---AKLGMPQFLS------------PEAQS-LLRMLFKRNPANRLGAGPDGVEEIKRHSFF-----
----WEIIGELGDGAFGKV---YKAQNK----------------ETSV---LAAA-KVI---DTK--SEEELE---D-YM--V----EIDILASC-DHPNIVKLLDAFY--YENN------LWILIEFCAGGAVDAVML--ELER-----------------------------------------------------------------------------------------------------PL---TESQIQVVCKQTLDALNYLHD--N--K---IIHRDLKAGNILFT-L-----DG-DI---------KLADFGVSAKN-----------------TRTIQRR------------DS---FIGTPYWMAPEVVMCETSKDRP-YDYKADVWSLGITLIEMAE-IE-PP---------------HHEL---NPMRVLLKI----AK----SEP---PTLAQPSRWS------------SNFKD-FLKKCLEKNVDARWT-----TSQLLQHPFV-----
---L-RLEVKLGQGCFGEV---WMGTWN-----------------GTT---RVAI-KTL---K-P--GTM-SP---E-AFL-Q----EAQVMKKL-RHEKLVQLYAVVS---EEP------IYIVTEYMSKGSLLDFLK----GE-------------------------------------------------------------------------------------------------TG-KYL---RLPQLVDMAAQIASGMAYVER--M--N---YVHRDLRAANILVG-E-----NL-VC---------KVADFGLARLI-----------------E--DNEY------------TARQGAKFPIKWTAPEAAL-----YGR-FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM---VNREVLDQV----ER----GYR---MPCPPECP--------------ESLHD-LMCQCWRKEPEERPT-----FEYLQAF--L-----
--FA--LGRKLGEGYFGEV---WEGLWL-----------------GSL---PVAI-KVI---K-S--ANM-K---LT-DLA-K----EIQTLKGL-RHERLIRLHAVCS--GGEP------VYIVTELMRKGNLQAFLG----TP-------------------------------------------------------------------------------------------------EG-RAL---RLPPLLGFACQVAEGMSYLEE--Q--R---VVHRDLAARNVLVD-D-----GL-AC---------KVADFGLARLL-----------------K--DDIY------------SPSSSSKIPVKWTAPEAAN-----YRV-FSQKSDVWSFGVLLHEVFTYGQ-CP---------------YEGM---TNHETLQQI----MR----GYR---LPRPAACP--------------AEVYV-LMLECWRSSPEERPS-----FATLREKL-------
----FTKLEKIGKGSFGEV---FKGIDN----------------RTQK---VVAI-KII---DLE--EAEDEI---E-DIQ-Q----EITVLSQC-DSPYVTKYYGSYL--KDTK------LWIIMEYLGGGSALDLLE----PG-----------------------------------------------------------------------------------------------------PL---DETQIATILREILKGLDYLHS--E--K---KIHRDIKAANVLLS-E-----HG-EV---------KLADFGVAGQL-----------------TDTQIKR------------NT---FVGTPFWMAPEVIK-----QSA-YDSKADIWSLGITAIELAR-GE-PP---------------HSEL---HPMKVLFLI----PK----NNP---PTLEGNYS--------------KPLKE-FVEACLNKEPSFRPT-----AKELLKHKFI-----
---F-DVLEKLGEGSYGSV---FKAIHK----------------ESGQ---VVAI-KQV---PVE--SDLQEI--------IK----EISIMQQC-DSPYVVKYYGSYF--KNTD------LWIVMEYCGAGSVSDIIR--LRNK-----------------------------------------------------------------------------------------------------TL---IEDEIATILKSTLKGLEYLHF--M--R---KIHRDIKAGNILLN-T-----EG-HA---------KLADFGVAGQL-----------------TDTMAKR------------NT---VIGTPFWMAPEVIQ-----EIG-YNCVADIWSLGITSIEMAE-GK-PP---------------YADI---HPMRAIFMI----PT----NPP---PTFRKPELWS------------DDFTD-FVKKCLVKNPEQRAT-----ATQLLQHPFI-----
----YHVLEMIGEGSFGRV---YKGRRK----------------YSAQ---VVAL-KFI---PKL--GRSEKE---L-RNLQR----EIEIMRGL-RHPNIVHMLDSFE--TDKE------VVVVTDYAEG-ELFQILE---DDG-----------------------------------------------------------------------------------------------------KL---PEDQVQAIAAQLVSALYYLHS--H--R---ILHRDMKPQNILLA-K-----GG-GI---------KLCDFGFARAM-----------------STNTMVL------------TS---IKGTPLYMSPELVE-----ERP-YDHTADLWSVGCILYELAV-GT-PP---------------FYAT------SIFQLV----SL----ILK---DPVRWPSTIS------------PCFKN-FLQGLLTKDPRQRLS-----WPDLLYHPFI-----
---F-DVLEKLGEGSYGSV---YKAIHK----------------ETGQ---IVAI-KQV---PVE--SDLQEI--------IK----EISIMQQC-DSPHVVKYYGSYF--KNTD------LWIVMEYCGAGSVSDIIR--LRNK-----------------------------------------------------------------------------------------------------TL---TEDEIATILQSTLKGLEYLHF--M--R---KIHRDIKAGNILLN-T-----EG-HA---------KLADFGVAGQL-----------------TDTMAKR------------NT---VIGTPFWMAPEVIQ-----EIG-YNCVADIWSLGITAIEMAE-GK-PP---------------YADI---HPMRAIFMI----PT----NPP---PTFRKPELWS------------DNFTD-FVKQCLVKSPEQRAT-----ATQLLQHPFV-----
-TLE---DKELGSGNFGTV---KKGYYQ--------------MKKVVK---TVAV-KIL---K-N--EAN-DPALKD-ELL-A----EANVMQQL-DNPYIVRMIGICE---AES------WMLVMEMAELGPLNKYLQ----QN----------------------------------------------------------------------------------------------------RHV---KDKNIIELVHQVSMGMKYLEE--S--N---FVHRDLAARNVLLV-T-----QH-YA---------KISDFGLSKAL-------------R---A--DENY-----------YKAQTHGKWPVKWYAPECIN-----YYK-FSSKSDVWSFGVLMWEAFSYGQ-KP---------------YRGM---KGSEVTAML----EK----GER---MGCPAGCP--------------REMYD-LMNLCWTYDVENRPG-----FAAVE----LRL---
----LTFMRELGSGLFGVV---RLGKWR-----------------AQY---KVAI-KAI---R-E--GAM-CE---E-DFI-E----EAKVMMKL-THPKLVQLYGVCT--QQKP------IYIVTEFMERGCLLNFLR----QR--------------------------------------------------------------------------------------------------Q-GHF---SRDVLLSMCQDVCEGMEYLER--N--S---FIHRDLAARNCLVS-E-----AG-VV---------KVSDFGMARYV-----------------L--DDQY------------TSSSGAKFPVKWCPPEVFN-----YSR-FSSKSDVWSFGVLMWEVFTEGR-MP---------------FEKY---TNYEVVTMV----TR----GHR---LYQPKLAS--------------NYVYE-VMLRCWQEKPEGRPS-----FEDLLRT--I-----
----IKFQDVIGEGNFGQV---LKARIK--------------KDGLRM---DAAI-KRM---K-E--YAS-KDD-HR-DFA-G----ELEVLCKLGHHPNIINLLGACE--HRGY------LYLAIEYAPHGNLLDFLR----KSRVLETDP-----------------------------------------------------------------------------------AFAIANSTA-STL---SSQQLLHFAADVARGMDYLSQ--K--Q---FIHRDLAARNILVG-E-----NY-VA---------KIADFGLSRGQ---------------------EVY------------VKKTMGRLPVRWMAIESLN-----YSV-YTTNSDVWSYGVLLWEIVSLGG-TP---------------YCGM---TCAELYEKL----PQ----GYR---LEKPLNCD--------------DEVYD-LMRQCWREKPYERPS-----FAQILV---SL----
----ITFEDLIGEGNFGQV---IRAMIK--------------KDGLKM---NAAI-KML---K-E--YAS-END-HR-DFA-G----ELEVLCKLGHHPNIINLLGACK--NRGY------LYIAIEYAPYGNLLDFLR----KSRVLETDP-----------------------------------------------------------------------------------AFAREHGTA-STL---SSRQLLRFASDAANGMQYLSE--K--Q---FIHRDLAARNVLVG-E-----NL-AS---------KIADFGLSRGE---------------------EVY------------VKKTMGRLPVRWMAIESLN-----YSV-YTTKSDVWSFGVLLWEIVSLGG-TP---------------YCGM---TCAELYEKL----PQ----GYR---MEQPRNCD--------------DEVYE-LMRQCWRDRPYERPP-----FAQIALQ--L-----
-VCR---GELLGSGCFGVV---HRGLWT-------------LPSGKSV---PVAV-KSLRVGP-E--GPM-GTE-LG-DFL-R----EVSVMMNL-EHPHVLRLHGLVL---GQP------LQMVMELAPLGSLHARLT----AP------------------------------------------------------------------------------------------------APT-PPL---LVALLCLFLRQLAGAMAYLGA--R--G---LVHRDLATRNLLLA-S-----PR-TI---------KVADFGLVRPL------------GG---A--RGRY------------VMGGPRPIPYAWCAPESLR-----HGA-FSSASDVWMFGVTLWEMFSGGE-EP---------------WAGV---PPYLILQRL----ED----RAR---LPRPPLCS--------------RALYS-LALRCWAPHPADRPS-----FSHLE----GLL---
---L-RLLEKLGDGSFGVV---RRGEWD-------------APSGKTV---SVAV-KCL---K-PDVLSQ-PEA-MD-DFI-R----EVNAMHSL-DHRNLIRLYGVVL---TPP------MKMVTELAPLGSLLDRLR----KH--------------------------------------------------------------------------------------------------Q-GHF---LLGTLSRYAVQVAEGMGYLES--K--R---FIHRDLAARNLLLA-T-----RD-LV---------KIGDFGLMRAL------------PQ---N--DDHY------------VMQEHRKVPFAWCAPESLK-----TRT-FSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL---NGSQILHKI---DKE----GER---LPRPEDCP--------------QDIYN-VMVQCWAHKPEDRPT-----FVALRDF--L-----
----IEFHEIIGSGSFGKV---YKGRCR------------------NK---IVAI-KRY---R-ANTYCS-KSD-VD-MFC-R----EVSILCQL-NHPCVIQFVGACL-NDPSQ------FAIVTQYISGGSLFSLLH----EQ--------------------------------------------------------------------------------------------------K-RIL---DLQSKLIIAVDVAKGMEYLHNLTQ--P---IIHRDLNSHNILLY-E-----DG-HA---------VVADFGESRFL-------------Q---S--LD-E------------DNMTKQPGNLRWMAPEVFT-----QCTRYTIKADVFSYALCLWEILT-GE-IP---------------FAHL---KPAAAAADM---AYH----HIR---PPIGYSIP--------------KPISS-LLIRGWNACPEGRPE-----FSEVVMKL-------
---L-AFIKEIGSGQFGVV---HLGEWR-----------------SHI---QVAI-KAI---N-E--GSM-SE---E-DFI-E----EAKVMMKL-SHSKLVQLYGVCI--QRKP------LYIVTEFMENGCLLNYLR----EN--------------------------------------------------------------------------------------------------K-GKL---RKEMLLSVCQDICEGMEYLER--N--G---YIHRDLAARNCLVS-S-----TC-IV---------KISDFGMTRYV-----------------L--DDEY------------VSSFGAKFPIKWSPPEVFL-----FNK-YSSKSDVWSFGVLMWEVFTEGK-MP---------------FENK---SNLQVVEAI----SE----GFR---LYRPHLAP--------------MSIYE-VMYSCWHEKPEGRPT-----FAELLR---AV----
---L-KKIRDLGEGHFGKV---SLYCYDP------------TNDGTGE---MVAV-KAL---K-A--DCG-PQH-RS-GWK-Q----EIDILRTL-YHEHIIKYKGCCEDQGEKS------LQLVMEYVPLGSLRDYLP----RH-----------------------------------------------------------------------------------------------------SI---GLAQLLLFAQQICEGMAYLHA--Q--H---YIHRDLAARNVLLD-N-----DR-LV---------KIGDFGLAKAV------------PE---G--HEYY------------RVREDGDSPVFWYAPECLK-----EYK-FYYASDVWSFGVTLYELLTHCD-SSQSPPTKF-LELIGIAQGQM---TVLRLTELL----ER----GER---LPRPDKCP--------------CEVYH-LMKNCWETEASFRPT-----FENLIP---IL----
---F-TLGRMLGKGEFGSV---REAQLK-------------QEDGSFV---KVAV-KML---K-A-DIIA-SSD-IE-EFL-R----EAACMKEF-DHPHVAKLVGVSL--RSRAKGRLPIPMVILPFMKHGDLHAFLL----ASRI---------------------------------------------------------------------------------------------GENP-FNL---PLQTLIRFMVDIACGMEYLSS--R--N---FIHRDLAARNCMLA-E-----DM-TV---------CVADFGLSRKI-------------Y---S--GDYY------------RQGCASKLPVKWLALESLA-----DNL-YTVQSDVWAFGVTMWEIMTRGQ-TP---------------YAGI---ENAEIYNYL----IG----GNR---LKQPPECM--------------EDVYD-LMYQCWSADPKQRPS-----FTCLRME--L-----
--FS--RKDLIGHGAFAVV---FKGRHR----------------EKHD--LEVAV-KCI---NKK--NLAKSQ---T--LLGK----EIKILKEL-KHENIVALYDFQE--MANS------VYLVMEYCNGGDLADYLH---AMR-----------------------------------------------------------------------------------------------------TL---SEDTIRLFLQQIAGAMRLLHS--K--G---IIHRDLKPQNILLS-N-----PA-GRRANPNSIRVKIADFGFARY------------------LQSNMMA------------AT---LCGSPMYMAPEVIM-----SQH-YDGKADLWSIGTIVYQCLT-GK-AP---------------FQAS---SPQDLRLFY----EK----NKT---LVPTIPRETS------------APLRQ-LLLALLQRNHKDRMD-----FDEFFHHPFL-----
---Y-SKRDLVGHGAFAVV---FRGRHR----------------QKTD--WEVAI-KSI---NKK--NLSKSQ-----ILLGK----EIKILKEL-QHENIVALYDVQE--LPNS------VFLVMEYCNGGDLADYLQ---AKG-----------------------------------------------------------------------------------------------------TL---SEDTIRVFLHQIAAAMRILHS--K--G---IIHRDLKPQNILLS-Y-----AN-RRKSSVSGIRIKIADFGFARY------------------LHSNMMA------------AT---LCGSPMYMAPEVIM-----SQH-YDAKADLWSIGTVIYQCLV-GK-PP---------------FQAN---SPQDLRMFY----EK----NRS-----LMPSIPRETS----------PYLAN-LLLGLLQRNQKDRMD-----FEAFFSHPFL-----
---L-RLEVKLGQGCFGEV---WMGTWN-----------------GTT---KVAI-KTL---K-P--GTM-MP---E-AFL-Q----EAQIMKKL-RHDKLVPLYAVVS---EEP------IYIVTEFMSKGSLLDFLK----EG-------------------------------------------------------------------------------------------------DG-KYL---KLPQLVDMAAQIADGMAYIER--M--N---YIHRDLRAANILVG-E-----NL-VC---------KIADFGLARLI-----------------E--DNEY------------TARQGAKFPIKWTAPEAAL-----YGR-FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM---VNREVLEQV----ER----GYR---MPCPQGCP--------------ESLHE-LMNLCWKKDPDERPT-----FEYIQSFL-------
----WTKGEILGKGAYGTV---YCGLTS----------------QGQ----LIAV-KQV---ALD--TSNKLA---A-EKEYRKLQEEVDLLKAL-KHVNIVAYLGTCL--QENT------VSIFMEFVPGGSISSIIN---RFG-----------------------------------------------------------------------------------------------------PL---PEMVFCKYTKQILQGVAYLHE--N--C---VVHRDIKGNNVMLM-P-----TG-II---------KLIDFGCARRLAWA-----------GLNGTHSDML------------KS---MHGTPYWMAPEVIN-----ESG-YGRKSDIWSIGCTVFEMAT-GK-PP---------------LASM-----DRMAAMF----YI----GAH---RGLMPPLPDHFS----------ENAAD-FVRMCLTRDQHERPS-----ALQLLKHSFL-----
LIAD----IELGCGNFGSV---RQGVYR--------------MRKKQI---DVAI-KVL---K-Q--GTE-KAD-TE-EMM-R----EAQIMHQL-DNPYIVRLIGVCQ---AEA------LMLVMEMAGGGPLHKFLV----GK--------------------------------------------------------------------------------------------------R-EEI---PVSNVAELLHQVSMGMKYLEE--K--N---FVHRDLAARNVLLV-N-----RH-YA---------KISDFGLSKAL------------GA---D--DSYY------------TARSAGKWPLKWYAPECIN-----FRK-FSSRSDVWSYGVTMWEALSYGQ-KP---------------YKKM---KGPEVMAFI----EQ----GKR---MECPPECP--------------PELYA-LMSDCWIYKWEDRPD-----FLTVEQR--M-----
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