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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC STK32A 203
TK EPHB2 621
CMGC GSK3B 56
TK LCK 245
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK11 24
CMGC MAPK12 27
CMGC MAPK14 24
CMGC MAPK8 26
CMGC NLK 126
TK PTK6 191
AGC RPS6KA1 62
AGC RPS6KA6 73
TK SRC 270
TK TXK 271
---FEILRAIGKGSFGKV---CIVQKN---DTKK---MYAMKYMNKQKCVERN--EVRNVFKELQIMQGLEHPFLVNLWYSFQD------EEDMF--MVVDLLLGG--DLRYHLQ----QNV---HFKEETVKLFICELVMALDYLQNQRIIHRDMKPDNILLD-EHGHVHITDFNIAAM-------LPRETQITT---MAGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLR-GRRPYHIRSSTSSKEIVHTFETTVVTYPSAWS---------------------------------------QEMVSLLKKLLEPNPDQRFS----QLSDVQNFPY-M-
--V-KIEQVIGAGEFGEV---CSGHLKLPGKREI---FVAIKTLK-SGYT-EKQRRDFL-S-EASIMGQFDHPNVIHLEGVVTK------STPVM--IITEFMENG--SLDSFLR-----QN-DGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVN-SNLVCKVSDFGLSRFLEDDT--S--DPTYTSALGGKIPIRWTAPEA--IQ-YRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCP-----------------------------------------SALHQLMLDCWQKDRNHRPK-----FGQIVNTL----
---YTDTKVIGNGSFGVV---YQAKLC---DSGE---LVAIKKVLQDKRFKNR---------ELQIMRKLDHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-------LVRGEPNVS---YICSRYYRAPEL--IFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF--
---LKLVERLGAGQFGEV---WMGYYN----GHT---KVAVKSLK-QGSM-SP--DAFL-A-EANLMKQLQHQRLVRLYAVVT-------QEPIY--IITEYMENG--SLVDFLK-----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLI------E--DNEYTAREGAKFPIKWTAPEA--IN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L--
---YTNLSYIGEGAYGMV---CSAYDN---VNKV---RVAIKKISPFEHQTYC--QRT-LR-EIKILLRFRHENIIGINDIIRAPT-IEQMKDVY--IVQDLMET---DLYKLLK-----TQ---HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGLARVAD---PDHDHTGFLTE---YVATRWYRAPEI--MLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIE-----VEQALAHPYL--
---YQNLKPIGSGAQGIV---CAAYDA---VLDR---NVAIKKLSRPFQNQTH--AKRAYR-ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART-------AGTSFMMTP---YVVTRYYRAPEV--IL-GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI--
LQG---LRPVGSGAYGSV---CSAYDA---RLRQ---KVAVKKLSRPFQSLIH--ARRTYR-ELRLLKHLKHENVIGLLDVFTPATSIEDFSEVY--LVTTLMGA---DLNNIVK-----CQ---ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLAR---------QADEEMTG---YVATRWYRAPEI--MLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-----------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS-----AAEALAHAYF--
---YRDLQPVGSGAYGAV---CSAVDG---RTGA---KVAIKKLYRPFQSELF--AKRAYR-ELRLLKHMRHENVIGLLDVFTPDETLDDFTDFY--LVMPFMGT---DLGKLMK-----HE---KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGLAR---------QADSEMTG---YVVTRWYRAPEV--ILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-----------KKDFASILTNASPLAVNLLEKMLVLDAEQRVT-----AGEALAHPYF--
---YQNLSPVGSGAYGSV---CAAFDT---KTGL---RVAVKKLSRPFQSIIH--AKRTYR-ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR---------HTDDEMTG---YVATRWYRAPEI--MLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF--
---YQNLKPIGSGAQGIV---CAAYDA---ILER---NVAIKKLSRPFQNQTH--AKRAYR-ELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART-------AGTSFMMTP---YVVTRYYRAPEV--IL-GMGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VDEALQHPYI--
IEP---DRPIGYGAFGVV---WSVTDP---RDGK---RVALKKMPNVFQNLVS--CKRVFR-ELKMLCFFKHDNVLSALDILQPPH-IDYFEEIY--VVTELMQS---DLHKIIV----SPQ---PLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVN-SNCVLKICDFGLARVE-----ELDESRHMTQ---EVVTQYYRAPEI--LMGSRHYSNAIDIWSVGCIFAELLG-RRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQP----------SLPVLYTLSSQATHEAVHLLCRMLVFDPSKRIS-----AKDALAHPYL--
--F-TLCRKLGSGYFGEV---FEGLWK----DRV---QVAIKVIS-RDNL-LH-QQMLQ-S-EIQAMKKLRHKHILALYAVVSV------GDPVY--IITELMAKG--SLLELLR-----DSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVG-ENTLCKVGDFGLARLI---------KEDVYLSHDHNIPYKWTAPEA--LS-RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECP-----------------------------------------PSVHKLMLTCWCRDPEQRPC-----FKALRERL----
---FELLKVLGQGSFGKVFLVRKVTRP---DSGH---LYAMKVLKKATLKVRD--RVRTKM-ERDILADVNHPFVVKLHYAFQT------EGKLY--LILDFLRGG--DLFTRLS----KEV---MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLD-EEGHIKLTDFGLSKEA------IDHEKKAYS---FCGTVEYMAPEV--VN-RQGHSHSADWWSYGVLMFEMLT-GSLPFQGK---DRKETMTLILKAKLGMPQFLS---------------------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY
---FELLKVLGQGSFGKV---FLVRKK---TGPDAGQLYAMKVLKKASLKVRD--RVRTKM-ERDILVEVNHPFIVKLHYAFQT------EGKLY--LILDFLRGG--DVFTRLS----KEV---LFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLD-EIGHIKLTDFGLSKES------VDQEKKAYS---FCGTVEYMAPEV--VN-RRGHSQSADWWSYGVLMFEMLT-GTLPFQGK---DRNETMNMILKAKLGMPQFLS---------------------------------------AEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF--
--L-RLEVKLGQGCFGEV---WMGTWN----GTT---RVAIKTLK-PGTM-SP--EAFL-Q-EAQVMKKLRHEKLVQLYAVVS-------EEPIY--IVTEYMSKG--SLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLI------E--DNEYTARQGAKFPIKWTAPEA--AL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L--
--L-AFIKEIGSGQFGVV---HLGEWR----SHI---QVAIKAIN-EGSM-SE--EDFI-E-EAKVMMKLSHSKLVQLYGVCIQ------RKPLY--IVTEFMENG--CLLNYLR-----EN-KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVS-STCIVKISDFGMTRYV------L--DDEYVSSFGAKFPIKWSPPEV--FL-FNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAP-----------------------------------------MSIYEVMYSCWHEKPEGRPT-----FAELLR---AV-
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