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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK STK33 203
Other AURKA 133
Other AURKB 77
CMGC CDC2 4
CMGC CDK2 4
TK EGFR 712
TK LYN 247
CMGC MAPK10 64
CMGC MAPK8 26
CMGC MAPK9 26
AGC PDPK1 82
-YTFGRILGKGSFGIVIEATDK----ETETKWAIKKVNKEK-AGSSA--VK-LLER-EVNILKSVKHEHIIHLEQVFET------PKKMYLVMELCEDGELKEILD---RKG---HFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKK--QSRSEAMLQA---TCGTPIYMAPEVIS-AHDYSQQCDIWSIGVVMYMLLR-GEPPFLAS---SEEKLFELIRKGELHFENAVWNSIS-----------------------------------DCAKSVLKQLMKVDPAHRITAKELLDNQWL-----------
-FEIGRPLGKGKFGNVYLAREK----QSKFILALKVLFKAQLEKAGV--EH-QLRR-EVEIQSHLRHPNILRLYGYFHD------ATRVYLILEYAPLGTVYRELQ---KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGEL---------KIADFGWSV-----HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-----------
-FEIGRPLGKGKFGNVYLAREK----KSHFIVALKVLFKSQ-IEKEG--VE-HQLRREIEIQAHLHHPNILRLYNYFYD------RRRIYLILEYAPRGELYKELQ---KSC---TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGEL---------KIADFGWSV-----HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV-----------
-YTKIEKIGEGTYGVVYKGRHK----TTGQVVAMKKIRLES-EEEGV--PS-TAIR-EISLLKELRHPNIVSLQDVLMQ------DSRLYLIFEFLSM-DLKKYLDSIPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI---------KLADFGLARAF---GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF-----------
-FQKVEKIGEGTYGVVYKARNK----LTGEVVALKKIRLDT-ETEGV--PS-TAIR-EISLLKELNHPNIVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDA-SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI---------KLADFGLARAF---GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-----------
F-KKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EA-TS-PKANKE-IL-D-EAYVMASVDNPHVCRLLGICL-------TSTVQLITQLMPFGCLLDYVR----EH-KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHV---------KITDFGLAKLL-G-A--EEKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT-----------------------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF---------
-IKLVKRLGAGQFGEVWMGYYN-----NSTKVAVKTLK-PG-TM-SV--QA-FL-E-EANLMKTLQHDKLVRLYAVVTR------EEPIYIITEYMAKGSLLDFLK----SDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMC---------KIADFGLARVI---E--DNEYTAREGAKFPIKWTAPEAIN-FGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCP-----------------------------------------DELYDIMKMCWKEKAEERPTFDYLQSV--L-----------
-YQNLKPIGSGAQGIVCAAYDA----VLDRNVAIKKLSRPF-QNQTH--AK-RAYR-ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ-----M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL---------KILDFGLART----AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI-----------
-YQNLKPIGSGAQGIVCAAYDA----ILERNVAIKKLSRPF-QNQTH--AK-RAYR-ELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQ-----M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL---------KILDFGLART----AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI-----------
-YQQLKPIGSGAQGIVCAAFDT----VLGINVAVKKLSRPF-QNQTH--AK-RAYR-ELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIH-----M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL---------KILDFGLART----ACTNFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVK-GCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI-----------
F-KFGKILGEGSFSTVVLAREL----ATSREYAIKILEKRH-IIKEN--KVPYVTR-ERDVMSRLDHPFFVKLYFTFQD------DEKLYFGLSYAKNGELLKYIR---KIG---SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHI---------QITDFGTAKVLS-PESKQARANS---FVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
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