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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK STK33 203
CAMK CAMK2A 13
CAMK CAMK2D 14
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK9 2.7.11.23
CAMK CHEK2 220
CMGC CLK1 161
CMGC CLK2 163
CMGC CLK3 156
CMGC CLK4 159
CMGC CSNK2A2 40
CAMK DAPK3 13
CMGC DYRK1A 150
CMGC DYRK1B 111
CMGC GSK3A 119
CMGC GSK3B 56
CMGC MAPK10 64
CMGC MAPK8 26
CMGC NLK 126
CMGC SRPK1 80
CMGC SRPK2 81
CMGC SRPK3 79
---YTFGRILGKGSFGIVIEATDKE-T-ET-KWAIKKVNKEKAGSSAVKLLER------EVNILKSV-K--------HEH-----IIHLEQVFET--------PKKMY--LVMELCEDG--ELKEILD----RKGHF---SENETRWIIQSLASAIAYLHN--N-DIVHRDLKLENIMVK--SSLIDDNNE-----------INLNIKVTDFGLAVKK---QSRSEAMLQATCGTPIYMAPEVIS---AHDYSQQCDIWSIGVVMYMLLR-GEPPFL-AS---SEEKLFELIRKGELHFENAVWNSIS---------------------------------------------------------DCAKSVLKQLMKVDPAHRITAKELLDNQWL-------
---YQLFEELGKGAFSVVRRCVKVL-A-GQ-EYAAKIINTKKLSARDHQKLER------EARICRLL-K--------HPN-----IVRLHDSISE--------EGHHY--LIFDLVTGG--ELFEDIV----AREYY---SEADASHCIQQILEAVLHCHQ--M-GVVHRDLKPENLLLA--SKLKGA-----------------AVKLADFGLAIEV----EGEQQAWFGFAGTPGYLSPEVLR---KDPYGKPVDLWACGVILYILLV-GYPPFW-DE---DQHRLYQQIKAGAYDFPSPEWDTVT---------------------------------------------------------PEAKDLINKMLTINPSKRITAAEALKHPWI-------
---YQLFEELGKGAFSVVRRCMKIP-T-GQ-EYAAKIINTKKLSARDHQKLER------EARICRLL-K--------HPN-----IVRLHDSISE--------EGFHY--LVFDLVTGG--ELFEDIV----AREYY---SEADASHCIQQILESVNHCHL--N-GIVHRDLKPENLLLA--SKSKGA-----------------AVKLADFGLAIEV----QGDQQAWFGFAGTPGYLSPEVLR---KDPYGKPVDMWACGVILYILLV-GYPPFW-DE---DQHRLYQQIKAGAYDFPSPEWDTVT---------------------------------------------------------PEAKDLINKMLTINPAKRITASEALKHPWI-------
---YTKIEKIGEGTYGVVYKGRHKT-T-GQ-VVAMKKIRLESEEEGVPSTAIR------EISLLKEL-R--------HPN-----IVSLQDVLMQ--------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYM---DSSLVKSYLYQILQGIVFCHS--R-RVLHRDLKPQNLLID--DKGTI--------------------KLADFGLARAF----GIPIRVYTHEVVTLWYRSPEVLL--GSARYSTPVDIWSIGTIFAELAT-KKPLFH-GDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF-------
---FQKVEKIGEGTYGVVYKARNKL-T-GE-VVALKKIRLDTETEGVPSTAIR------EISLLKEL-N--------HPN-----IVKLLDVIHT--------ENKLY--LVFEFLHQ---DLKKFMDA--SALTGI---PLPLIKSYLFQLLQGLAFCHS--H-RVLHRDLKPQNLLIN--TEGAI--------------------KLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-------
---FQKVEKIGEGTYGVVYKAKNRE-T-GQ-LVALKKIRLDLEMEGVPSTAIR------EISLLKEL-K--------HPN-----IVRLLDVVHN--------ERKLY--LVFEFLSQ---DLKKYMDS--TPGSEL---PLHLIKSYLFQLLQGVSFCHS--H-RVIHRDLKPQNLLIN--ELGAI--------------------KLADFGLARAF----GVPLRTYTHEVVTLWYRAPEILL--GSKFYTTAVDIWSIGCIFAEMVT-RKALFP-GDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-----------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF-------
---YEKLEKIGEGTYGTVFKAKNRE-T-HE-IVALKRVRLDDDDEGVPSSALR------EICLLKEL-K--------HKN-----IVRLHDVLHS--------DKKLT--LVFEFCDQ---DLKKYFD---SCNGDL---DPEIVKSFLFQLLKGLGFCHS--R-NVLHRDLKPQNLLIN--RNGEL--------------------KLADFGLARAF----GIPVRCYSAEVVTLWYRPPDVLF--GAKLYSTSIDMWSAGCIFAELANAGRPLFP-GNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-----------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF-------
---YECVAEIGEGAYGKVFKARDLK-N-GGRFVALKRVRVQTGEEGMPLSTIR------EVAVLRHL-ET-----FEHPN-----VVRLFDVCTVSR---TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEPGV---PTETIKDMMFQLLRGLDFLHS--H-RVVHRDLKPQNILVT--SSGQI--------------------KLADFGLARI-----YSFQMALTSVVVTLWYRAPEVLL---QSSYATPVDLWSVGCIFAEMFR-RKPLFR-GSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ-------------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF-------
---YEKLAKIGQGTFGEVFKARHRK-T-GQ-KVALKKVLMENEKEGFPITALR------EIKILQLL-K--------HEN-----VVNLIEICRTKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLVKF---TLSEIKRVMQMLLNGLYYIHR--N-KILHRDMKAANVLIT--RDGVL--------------------KLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLL--GERDYGPPIDLWGAGCIMAEMWT-RSPIMQ-GNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK--------------------------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF-------
-YI--MSKTLGSGACGEVKLAFERK-T-CK-KVAIKIISKRKFAIGSAREADPALNVETEIEILKKL-N--------HPC-----IIKIKNFF-D--------AEDYY--IVLELMEGG--ELFDKVV----GNKRL---KEATCKLYFYQMLLAVQYLHE--N-GIIHRDLKPENVLLS--SQEEDC-----------------LIKITDFGHSKI-----LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFS-EH--RTQVSLKDQITSGKYNFIPEVWAEVS---------------------------------------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL-------
---YEIVDTLGEGAFGKVVECIDHK-AGGR-HVAVKIVKNVDRYCEAARS---------EIQVLEHL-NT------TDPNST-FRCVQMLEWFEH--------HGHIC--IVFELLGL---STYDFIK----ENGFLP-FRLDHIRKMAYQICKSVNFLHS--N-KLTHTDLKPENILFV--QSDYTEAYNPKIKR-DERTLINPDIKVVDFGSA-------TYDDEHHSTLVSTRHYRAPEVIL---ALGWSQPCDVWSIGCILIEYYL-GFTVFP-THDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRY--------------------VSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF-------
---YEIVSTLGEGTFGRVVQCVDHR-R-GGARVALKIIKNVEKYKEAAR---L------EINVLEKI-NEK---DPDNKN----LCVQMFDWFDY--------HGHMC--ISFELLGL---STFDFLK----DNNYLP-YPIHQVRHMAFQLCQAVKFLHD--N-KLTHTDLKPENILFV--NSDYELTYNLEKKR-DERSVKSTAVRVVDFGSAT-------FDHEHHSTIVSTRHYRAPEVIL---ELGWSQPCDVWSIGCIIFEYYV-GFTLFQ-THDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY--------------------VRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF-------
---YEIVGNLGEGTFGKVVECLDHA-R-GKSQVALKIIRNVGKYREAAR---L------EINVLKKI-KE-----KDKENK--FLCVLMSDWFNF--------HGHMC--IAFELLGK---NTFEFLK-----ENNFQPYPLPHVRHMAYQLCHALRFLHE--N-QLTHTDLKPENILFV--NSE-FETLYNEHKSCEEKSVKNTSIRVADFGSAT-------FDHEHHTTIVATRHYRPPEVIL---ELGWAQPCDVWSIGCILFEYYR-GFTLFQ-THENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRY--------------------VKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF-------
---YEIVDTLGEGAFGKVVECIDHGMD-GM-HVAVKIVKNVGRYREAARS---------EIQVLEHL-NS------TDPNSV-FRCVQMLEWFDH--------HGHVC--IVFELLGL---STYDFIK----ENSFLP-FQIDHIRQMAYQICQSINFLHH--N-KLTHTDLKPENILFV--KSDYVVKYNSKMKR-DERTLKNTDIKVVDFGSA-------TYDDEHHSTLVSTRHYRAPEVIL---ALGWSQPCDVWSIGCILIEYYL-GFTVFQ-THDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRY--------------------VRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF-------
---YQLVRKLGRGKYSEVFEAINIT-N-NE-RVVVKILKPVKKKKIKR-----------EVKILENLRG--------GTN-----IIKLIDTVKDP------VSKTPA--LVFEYINNT--DFKQLY-------QIL---TDFDIRFYMYELLKALDYCHS--K-GIMHRDVKPHNVMID-HQQKKL--------------------RLIDWGLAEF-----YHPAQEYNVRVASRYFKGPELLV--DYQMYDYSLDMWSLGCMLASMIF-RREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRK---------------------------RWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF-------
---YEMGEELGSGQFAIVRKCRQKG-T-GK-EYAAKFIKKRRLSSSRRGVSREEI--EREVNILREI-R--------HPN-----IITLHDIFEN--------KTDVV--LILELVSGG--ELFDFLA----EKESL---TEDEATQFLKQILDGVHYLHS--K-RIAHFDLKPENIMLL--DKNVPNP----------------RIKLIDFGIAHK-----IEAGNEFKNIFGTPEFVAPEIVN---YEPLGLEADMWSIGVITYILLS-GASPFL-GE---TKQETLTNISAVNYDFDEEYFSNTS---------------------------------------------------------ELAKDFIRRLLVKDPKRRMTIAQSLEHSWI-------
---YEIDSLIGKGSFGQVVKAYDRV-E-QE-WVAIKIIKNKKAFLNQAQI---------EVRLLELMNK--------HDTEMKYYIVHLKRHFMF--------RNHLC--LVFEMLSY---NLYDLLR-----NTNFRGVSLNLTRKFAQQMCTALLFLATPEL-SIIHCDLKPENILLCNPKRSAI--------------------KIVDFGSSCQ-------LGQRIYQYIQSRFYRSPEVLL---GMPYDLAIDMWSLGCILVEMHT-GEPLFS-GANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF-------
---YEIDSLIGKGSFGQVVKAYDHQ-T-QE-LVAIKIIKNKKAFLNQAQI---------ELRLLELMNQ--------HDTEMKYYIVHLKRHFMF--------RNHLC--LVFELLSY---NLYDLLR-----NTHFRGVSLNLTRKLAQQLCTALLFLATPEL-SIIHCDLKPENILLCNPKRSAI--------------------KIVDFGSSCQ-------LGQRIYQYIQSRFYRSPEVLL---GTPYDLAIDMWSLGCILVEMHT-GEPLFS-GSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF-------
---YTDIKVIGNGSFGVVYQARLAE-T-RE-LVAIKKVLQDKRFKNR------------ELQIMRKL-D--------HCN-----IVRLRYFFYSSG----EKKDELYLNLVLEYVPETVYRVARHFT---KAKLTI---PILYVKVYMYQLFRSLAYIHS--Q-GVCHRDIKPQNLLVD-PDTAVL--------------------KLCDFGSAKQ-----LVRGEPNVSYICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF-------
---YTDTKVIGNGSFGVVYQAKLCD-S-GE-LVAIKKVLQDKRFKNR------------ELQIMRKL-D--------HCN-----IVRLRYFFYSSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTL---PVIYVKLYMYQLFRSLAYIHS--F-GICHRDIKPQNLLLD-PDTAVL--------------------KLCDFGSAKQ-----LVRGEPNVSYICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-------
---YQNLKPIGSGAQGIVCAAYDAV-L-DR-NVAIKKLSRPFQNQTHAKRAYR------ELVLMKCV-N--------HKN-----IISLLNVFTPQKT--LEEFQDVY--LVMELMDA---NLCQVIQ------MEL---DHERMSYLLYQMLCGIKHLHS--A-GIIHRDLKPSNIVVK--SDCTL--------------------KILDFGLART-----AGTSFMMTPYVVTRYYRAPEVIL---GMGYKENVDIWSVGCIMGEMVR-HKILFP-GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK----------------------LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI-------
---YQNLKPIGSGAQGIVCAAYDAI-L-ER-NVAIKKLSRPFQNQTHAKRAYR------ELVLMKCV-N--------HKN-----IIGLLNVFTPQKS--LEEFQDVY--IVMELMDA---NLCQVIQ------MEL---DHERMSYLLYQMLCGIKHLHS--A-GIIHRDLKPSNIVVK--SDCTL--------------------KILDFGLART-----AGTSFMMTPYVVTRYYRAPEVIL---GMGYKENVDLWSVGCIMGEMVC-HKILFP-GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK----------------------LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI-------
IEP---DRPIGYGAFGVVWSVTDPR-D-GK-RVALKKMPNVFQNLVSCKRVFR------ELKMLCFF-K--------HDN-----VLSALDILQPPH---IDYFEEIY--VVTELMQS---DLHKIIV----SPQPL---SSDHVKVFLYQILRGLKYLHS--A-GILHRDIKPGNLLVN--SNCVL--------------------KICDFGLARVE---ELDESRHMTQEVVTQYYRAPEILM--GSRHYSNAIDIWSVGCIFAELLG-RRILFQ-AQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQP--------------------------------SLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL-------
---YHVIRKLGWGHFSTVWLSWDIQ-G-KK-FVAMKVVKSAEHYTETA---LD------EIRLLKSV-RNSDPNDPNREM-----VVQLLDDFKISG----VNGTHIC--MVFEVLGHH--LLKWIIK---SNYQGL---PLPCVKKIIQQVLQGLDYLHT--KCRIIHTDIKPENILLS--VNEQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YIRRLA-
---YHVIRKLGWGHFSTVWLCWDMQ-G-KR-FVAMKVVKSAQHYTETA---LD------EIKLLKCV-RESDPSDPNKDM-----VVQLIDDFKISG----MNGIHVC--MVFEVLGHH--LLKWIIK---SNYQGL---PVRCVKSIIRQVLQGLDYLHS--KCKIIHTDIKPENILMC-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VDDAYVR
---YHVVRKLGWGHFSTVWLCWDIQ-R-KR-FVALKVVKSAGHYTETA---VD------EIKLLKCV-RDSDPSDPKRET-----IVQLIDDFRISG----VNGVHVC--MVLEVLGHQ--LLKWIIK---SNYQGL---PVPCVKSIVRQVLHGLDYLHT--KCKIIHTDIKPENILLC-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGDAYIR
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