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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other STK36 203
TK ABL1 261
Other AURKA 133
TK BMX 422
TK BTK 402
TK CSK 195
CAMK DCLK3 356
TK EGFR 712
TK ERBB2 720
TK FYN 271
TK HCK 241
TK IGF1R 999
TK JAK2 849
TK JAK3 822
TK KIT 589
TK LCK 245
TK PDGFRB 600
TK PTK6 191
TK RET 724
AGC RPS6KA1 62
AGC RPS6KA6 73
TK SRC 270
TK SYK 371
TK TNK2 150
TK TXK 271
TK TYK2 589
TK YES1 277
---YHVLEMIGEGSFGRV---YKGRRK-----YSAQ---VVALKFIPKL--G-RSEKE---LRNLQREIEIMRGL-RHPNIVHMLDSFE--TDKEVVVVTDYAEG-ELFQILEDDG----------------------------------------------------------------------------------------------------KLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGI----KLCDFGFARAM--STNTMVL-TS---IKGTPLYMSPELVEERPYDHTADLWSVGCILYELAV-GTPP---------------FYAT----SIFQLV-SLILKDPVRWPSTIS----PCFKNFLQGLLTKDPRQRLS-----WPDLLYHPFI--
---ITMKHKLGGGQYGEV---YEGVWK-----KYSL---TVAVKTLK-E--D-TM-EV---EEFL-KEAAVMKEI-KHPNLVQLLGVCT--REPPFYIITEFMTYGNLLDYLR-EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLV----KVADFGLSRLM--T--GDTY-TAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELL-EKDYRMERPEGCP------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F--
---FEIGRPLGKGKFGNV---YLAREK-----QSKF---ILALKVLFKA--QLEKAGV---EHQLRREVEIQSHL-RHPNILRLYGYFH--DATRVYLILEYAPLGTVYRELQKLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGEL----KIADFGWSV----HAPSSRR-TT---LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETY-KRISRVEFTFPDFVT----EGARDLISRLLKHNPSQRPM-----LREVLEHPWI--
---ITLLKELGSGQFGVV---QLGKWK------GQY---DVAVKMIK-E--G-SM-SE---DEFF-QEAQTMMKL-SHPKLVKFYGVCS--KEYPIYIVTEYISNGCLLNYLR-SH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCV----KVSDFGMTRYV--L--DDQY-VSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQP---------------YDLY-DNSQVVLKV-SQGHRLYRPHLAS------DTIYQIMYSCWHELPEKRPT-----FQQLLSS--I--
---LTFLKELGTGQFGVV---KYGKWR------GQY---DVAIKMIK-E--G-SM-SE---DEFI-EEAKVMMNL-SHEKLVQLYGVCT--KQRPIFIITEYMANGCLLNYLR-EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVV----KVSDFGLSRYV--L--DDEY-TSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMP---------------YERF-TNSETAEHI-AQGLRLYRPHLAS------EKVYTIMYSCWHEKADERPT-----FKILLSN--I--
---LKLLQTIGKGEFGDV---MLGDYR-------GN---KVAVKCIK-N--D-AT-AQ----AFL-AEASVMTQL-RHSNLVQLLGVIV-EEKGGLYIVTEYMAKGSLVDYLR-SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVA----KVSDFGLTKEA--------S-STQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVP---------------YPRI-PLKDVVPRV-EKGYKMDAPDGCP------PAVYEVMKNCWHLDAAMRPS-----FLQLREQL----
---YETGRVIGDGNFAVV---KECRHR-----ETRQ---AYAMKIIDKS--R-LKGKE---DMV-DSEILIIQSL-SHPNIVKLHEVYE--TDMEIYLILEYVQGGDLFDAIIESV----------------------------------------------------------------------------------------------------KFPEPDAALMIMDLCKALVHMHDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAK-----HVVRPI-FT---VCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLC-GFPP---------------FRSP--ERDQDELF-NIIQLGHFEFLPPYWDNISDAAKDLVSRLLVVDPKKRYT-----AHQVLQHPWI--
--F-KKIKVLGSGAFGTV---YKGLWIP-EGEKVKI---PVAIKELR-E--A-TS-PKA-NKEIL-DEAYVMASV-DNPHVCRLLGICL---TSTVQLITQLMPFGCLLDYVR-EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHV----KITDFGLAKLL-GA--EEKE-YHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSIL-EKGERLPQPPICT------IDVYMIMVKCWMIDADSRPK-----FRELI----IEF
--L-RKVKVLGSGAFGTV---YKGIWIP-DGENVKI---PVAIKVLR-E--N-TS-PKA-NKEIL-DEAYVMAGV-GSPYVSRLLGICL---TSTVQLVTQLMPYGCLLDHVR-EN--------------------------------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHV----KITDFGLARLL-DI--DETE-YHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKP---------------YDGI-PAREIPDLL-EKGERLPQPPICT------IDVYMIMVKCWMIDSECRPR-----FRELVSE--F--
---LQLIKRLGNGQFGEV---WMGTWN------GNT---KVAIKTLK-P--G-TM-SP---ESFL-EEAQIMKKL-KHDKLVQLYAVVS---EEPIYIVTEYMNKGSLLDFLK-DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLIC----KIADFGLARLI--E--DNEY-TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP---------------YPGM-NNREVLEQV-ERGYRMPCPQDCP------ISLHELMIHCWKKDPEERPT-----FEYLQSFL----
---LKLEKKLGAGQFGEV---WMATYN------KHT---KVAVKTMK-P--G-SM-SV---EAFL-AEANVMKTL-QHDKLVKLHAVVT---KEPIYIITEFMAKGSLLDFLK-SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVC----KIADFGLARVI--E--DNEY-TAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIP---------------YPGM-SNPEVIRAL-ERGYRMPRPENCP------EELYNIMMRCWKNRPEERPT-----FEYIQSV--L--
---ITMSRELGQGSFGMV---YEGVAKGVVKDEPET---RVAIKTVN-E--A-AS-MRE-RIEFL-NEASVMKEF-NCHHVVRLLGVVS--QGQPTLVIMELMTRGDLKSYLR-SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTV----KIGDFGMTRDI-YE--TDYY-RKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQP---------------YQGL-SNEQVLRFV-MEGGLLDKPDNCP------DMLFELMRMCWQYNPKMRPS-----FLEIISS--I--
---LKFLQQLGKGNFGSV---EMCRYDP-LQDNTGE---VVAVKKLQ-H--S-TE--EH-LRDFE-REIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ-KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRV----KIGDFGLTKVLPQD--KEYY-KVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELL-KNNGRLPRPDGCP------DEIYMIMTECWNNNVNQRPS-----FRDLA----LRV
--L-KYISQLGKGNFGSV---ELCRYDP-LGDNTGA---LVAVKQLQ-H--S-GP-DQ--QRDFQ-REIQILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ-RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHV----KIADFGLAKLLPLD--KDYY-VVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELL-EEGQRLPAPPACP------AEVHELMKLCWAPSPQDRPS-----FSALGP---QL-
---LSFGKTLGAGAFGKV---VEATAYGLIKSDAAM---TVAVKMLK-P--S-AH-LTE-REALM-SELKVLSYLGNHMNIVNLLGACT--IGGPTLVITEYCCYGDLLNFLR-RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRIT----KICDFGLARDI-KN--DSNY-VVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSP---------------YPGMPVDSKFYKMI-KEGFRMLSPEHAP------AEMYDIMKTCWDADPLKRPT-----FKQIVQL--I--
---LKLVERLGAGQFGEV---WMGYYN------GHT---KVAVKSLK-Q--G-SM-SP---DAFL-AEANLMKQL-QHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLK-TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSC----KIADFGLARLI--E--DNEY-TAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNL-ERGYRMVRPDNCP------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L--
--L-VLGRTLGSGAFGQV---VEATAHGLSHSQATM---KVAVKMLK-S--T-AR-SSE-KQALM-SELKIMSHLGPHLNVVNLLGACT--KGGPIYIITEYCRYGDLVDYLH-RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLV----KICDFGLARDI-MR--DSNY-ISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTP---------------YPELPMNEQFYNAI-KRGYRMAQPAHAS------DEIYEIMQKCWEEKFEIRPP-----FSQLVL---LL-
--F-TLCRKLGSGYFGEV---FEGLWK------DRV---QVAIKVIS-R--D-NL-LH--QQMLQ-SEIQAMKKL-RHKHILALYAVVS--VGDPVYIITELMAKGSLLELLR-DS-------------------------------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLC----KVGDFGLARLI-----KEDV-YLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVP---------------YPGM-SNHEAFLRV-DAGYRMPCPLECP------PSVHKLMLTCWCRDPEQRPC-----FKALRERL----
--L-VLGKTLGEGEFGKV---VKATAFHLKGRAGYT---TVAVKMLK-E--N-AS-PSE-LRDLL-SEFNVLKQV-NHPHVIKLYGACS--QDGPLLLIVEYAKYGSLRGFLR-ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKM----KISDFGLSRDV-YE--EDSY-VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-PPERLFNLL-KTGHRMERPDNCS------EEMYRLMLQCWKQEPDKRPV-----FADISKDL----
---FELLKVLGQGSFGKVFLVRKVTRP-----DSGH---LYAMKVLKKA--T-LKVRD---RVRTKMERDILADV-NHPFVVKLHYAFQ--TEGKLYLILDFLRGGDLFTRLSKEV----------------------------------------------------------------------------------------------------MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHI----KLTDFGLSKEA--IDHEKKA-YS---FCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLT-GSLP---------------FQGK----DRKETM-TLILKAKLGMPQFLS----TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY
---FELLKVLGQGSFGKV---FLVRKK-----TGPDAGQLYAMKVLKKA--S-LKVRD---RVRTKMERDILVEV-NHPFIVKLHYAFQ--TEGKLYLILDFLRGGDVFTRLSKEV----------------------------------------------------------------------------------------------------LFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHI----KLTDFGLSKES--VDQEKKA-YS---FCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLT-GTLP---------------FQGK----DRNETM-NMILKAKLGMPQFLS----AEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF--
--L-RLEVKLGQGCFGEV---WMGTWN------GTT---RVAIKTLK-P--G-TM-SP---EAFL-QEAQVMKKL-RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLK-GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC----KVADFGLARLI--E--DNEY-TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQV-ERGYRMPCPPECP------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L--
TLE---DKELGSGNFGTV---KKGYYQ---MKKVVK---TVAVKILK-N--E-AN-DPALKDELL-AEANVMQQL-DNPYIVRMIGICE---AESWMLVMEMAELGPLNKYLQ-QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA----KISDFGLSKAL-RA--DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKP---------------YRGM-KGSEVTAML-EKGERMGCPAGCP------REMYDLMNLCWTYDVENRPG-----FAAVE----LRL
--L-RLLEKLGDGSFGVV---RRGEWD--APSGKTV---SVAVKCLK-PDVL-SQ-PEA-MDDFI-REVNAMHSL-DHRNLIRLYGVVL---TPPMKMVTELAPLGSLLDRLR-KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLV----KIGDFGLMRALPQN--DDHY-VMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEP---------------WIGL-NGSQILHKIDKEGERLPRPEDCP------QDIYNVMVQCWAHKPEDRPT-----FVALRDF--L--
--L-AFIKEIGSGQFGVV---HLGEWR------SHI---QVAIKAIN-E--G-SM-SE---EDFI-EEAKVMMKL-SHSKLVQLYGVCI--QRKPLYIVTEFMENGCLLNYLR-EN--------------------------------------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIV----KISDFGMTRYV--L--DDEY-VSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMP---------------FENK-SNLQVVEAI-SEGFRLYRPHLAP------MSIYEVMYSCWHEKPEGRPT-----FAELLR---AV-
--L-KKIRDLGEGHFGKV---SLYCYDP-TNDGTGE---MVAVKALK-A--D-CG-PQH-RSGWK-QEIDILRTL-YHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLP-RH----------------------------------------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLV----KIGDFGLAKAVPEG--HEYY-RVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKF-LELIGIAQGQM-TVLRLTELL-ERGERLPRPDKCP------CEVYHLMKNCWETEASFRPT-----FENLIP---IL-
--L-RLEVKLGQGCFGEV---WMGTWN------GTT---KVAIKTLK-P--G-TM-MP---EAFL-QEAQIMKKL-RHDKLVPLYAVVS---EEPIYIVTEFMSKGSLLDFLK-EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVC----KIADFGLARLI--E--DNEY-TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVP---------------YPGM-VNREVLEQV-ERGYRMPCPQGCP------ESLHELMNLCWKKDPDERPT-----FEYIQSFL----
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