Protein Surface  Ribbon
Inhibitor 685
  ATP Location
Motifs All P-loop B3 Hinge
C-loop A-loop
Select Anchor
Summary of 3 kinases in KIF 3EMGA_685 (SYK, PDB code: 3EMG, chain A)

Multiple sequence alignment of family kinases

Conserved residues:   
                            
Group      Kinase           
TK         SYK          203 
TK         JAK1         875 
TK         ZAP70        338 



-TLE--DKELGSGNFGTVKKGYYQ--MKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICE--AES--WMLVMEMAELGPLNKYLQQN-RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL-RADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKP--------------YRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE--LRL
---LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNH-IADLKKEIEILRNLYHENIVKYKGICTED-GGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYY-TVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIE-GF-
LIAD---IELGCGNFGSVRQGVYR--MRKKQIDVAIKVLKQGTEKAD-TEEMMREAQIMHQLDNPYIVRLIGVCQ--AEA--LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYY-TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKP--------------YKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRM--