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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK TNK1 203
TK ABL1 261
Other AURKA 133
Other AURKB 77
CMGC CDK4 6
TK EGFR 712
TK JAK2 849
TK JAK3 822
TK LCK 245
Other PLK1 53
TK TNK2 150
VCR---GELLGSGCFGVVHRGLWT-LPSGKSVPVAVKSLRVGP-E--G-PM----GTELGDFL-R-EVSVMMNLE---HPHVLRLHGLVL--------GQPLQMVMELAPLGSLHARLT---APAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGA--RGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEP---------------WAGV-PPYLILQRL-EDRARLPRPPLCS--------------------------RALYSLALRCWAPHPADRPSFSHLE----GLL
---ITMKHKLGGGQYGEVYEGVWK----KYSLTVAVKTL---K-E--D-TM----EV--EEFL-K-EAAVMKEIK---HPNLVQLLGVCT--R-----EPPFYIITEFMTYGNLLDYLR---EC-NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--T--GDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELL-EKDYRMERPEGCP--------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F--
---FEIGRPLGKGKFGNVYLAREK----QSKFILALKVL---FKA--QLEKA---GV--EHQLRR-EVEIQSHLR---HPNILRLYGYFH--D-----ATRVYLILEYAPLGTVYRELQ--KLS----KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETY-KRISRVEFTFPDFVT------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
---FEIGRPLGKGKFGNVYLAREK----KSHFIVALKVL---FKS--Q-IEK---EG--VEHQLRREIEIQAHLH---HPNILRLYNYFY--D-----RRRIYLILEYAPRGELYKELQ--KSC----TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSV----HAPSLRRKT---MCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA----SHNETY-RRIVKVDLKFPASVP------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV--
--Y-EPVAEIGVGAYGTVYKARDP----HSGHFVALKSV---RVP--N-GGGGGGGL--PISTVR-EVALLRRLEAFEHPNVVRLMDVCA--TSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPP----GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI---YSYQMALTP---VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPL---------------FCGN-SEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL--
--F-KKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL---R-E--A-TS----PKANKEIL-D-EAYVMASVD---NPHVCRLLGICL--------TSTVQLITQLMPFGCLLDYVR---EH--KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL-GA--EEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSIL-EKGERLPQPPICT--------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF
---LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL---Q-H--S-TE-----EHLRDFE-R-EIEILKSLQ---HDNIVKYKGVCYSAG-----RRNLKLIMEYLPYGSLRDYLQ---KH--KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELL-KNNGRLPRPDGCP--------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
--L-KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQL---Q-H--S-GP----DQ-QRDFQ-R-EIQILKALH---SDFIVKYRGVSYGPG-----RQSLRLVMEYLPSGCLRDFLQ---RH--RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLD--KDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELL-EEGQRLPAPPACP--------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
---LKLVERLGAGQFGEVWMGYYN-----GHTKVAVKSL---K-Q--G-SM----SP--DAFL-A-EANLMKQLQ---HQRLVRLYAVVT--------QEPIYIITEYMENGSLVDFLK---TP-SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--E--DNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNL-ERGYRMVRPDNCP--------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--
-YV--RGRFLGKGGFAKCFEISDA----DTKEVFAGKIV---PKS--L-LLK---PH--QREKMSMEISIHRSLA---HQHVVGFHGFFE--D-----NDFVFVVLELCRRRSLLELHK--RRK----ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV--EYDGERKKT---LCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLV-GKPP---------------FETS----CLKETY-LRIKKNEYSIPKHIN------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF--
--L-RLLEKLGDGSFGVVRRGEWD-APSGKTVSVAVKCL---K-PDVL-SQ----PEAMDDFI-R-EVNAMHSLD---HRNLIRLYGVVL--------TPPMKMVTELAPLGSLLDRLR---KH--QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQN--DDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEP---------------WIGL-NGSQILHKIDKEGERLPRPEDCP--------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L--
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