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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK TNK1 203
TK ABL1 261
Other AURKA 133
Other AURKB 77
TK EGFR 712
TK JAK2 849
TK JAK3 822
TK LCK 245
STE MAP2K1 68
CMGC MAPK14 24
TK TNK2 150
VCR---GELLGSGCFGVVHRGLWT-LPSGKSVPVAVKSLRVGP-E--G-PM-GTELGDFL-R-EVSVMMNLEHPHVLRLHGLVL---------GQPLQMVMELAPLGSLHARLT-APAPTPPLLVALLCLFLRQLAGAMAYLGA-RGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGA--RGRYVMGGPRPIPYAWCAPESLR-HGAFSSASDVWMFGVTLWEMFSGGEEP---------------WAGV-PPYLILQRL-EDRARLPRPPLCS-------------------------------------------RALYSLALRCWAPHPADRPSFSHLE----GLL
---ITMKHKLGGGQYGEVYEGVWK----KYSLTVAVKTL---K-E--D-TM-EV--EEFL-K-EAAVMKEIKHPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR-EC-NRQEVNAVVLLYMATQISSAMEYLEK-KNFIHRDLAARNCLVGENHLVKVADFGLSRLM--T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELL-EKDYRMERPEGCP-------------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F--
---FEIGRPLGKGKFGNVYLAREK----QSKFILALKVL---FKA--QLEKAGV--EHQLRR-EVEIQSHLRHPNILRLYGYFH--D------ATRVYLILEYAPLGTVYRELQKLS----KFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLGSAGELKIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETY-KRISRVEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
---FEIGRPLGKGKFGNVYLAREK----KSHFIVALKVL---FKS--Q-IEKEG--VEHQLRREIEIQAHLHHPNILRLYNYFY--D------RRRIYLILEYAPRGELYKELQKSC----TFDEQRTATIMEELADALMYCHG-KKVIHRDIKPENLLLGLKGELKIADFGWSV----HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA----SHNETY-RRIVKVDLKFPASVP-----------------------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV--
--F-KKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL---R-E--A-TS-PKANKEIL-D-EAYVMASVDNPHVCRLLGICL---------TSTVQLITQLMPFGCLLDYVR-EH--KDNIGSQYLLNWCVQIAKGMNYLED-RRLVHRDLAARNVLVKTPQHVKITDFGLAKLL-GA--EEKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSIL-EKGERLPQPPICT-------------------------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF
---LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL---Q-H--S-TE--EHLRDFE-R-EIEILKSLQHDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ-KH--KERIDHIKLLQYTSQICKGMEYLGT-KRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELL-KNNGRLPRPDGCP-------------------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
--L-KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQL---Q-H--S-GP-DQ-QRDFQ-R-EIQILKALHSDFIVKYRGVSYGPG------RQSLRLVMEYLPSGCLRDFLQ-RH--RARLDASRLLLYSSQICKGMEYLGS-RRCVHRDLAARNILVESEAHVKIADFGLAKLLPLD--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELL-EEGQRLPAPPACP-------------------------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
---LKLVERLGAGQFGEVWMGYYN-----GHTKVAVKSL---K-Q--G-SM-SP--DAFL-A-EANLMKQLQHQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK-TP-SGIKLTINKLLDMAAQIAEGMAFIEE-RNYIHRDLRAANILVSDTLSCKIADFGLARLI--E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNL-ERGYRMVRPDNCP-------------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--
---FEKISELGAGNGGVVFKVSHK----PSGL-VMARKL---IHL--E-IKPAI--RNQIIR-ELQVLHECNSPYIVGFYGAFY--S------DGEISICMEHMDGGSLDQVLKKAG----RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG----QLIDSMANS---FVGTRSYMSPERLQ-GTHYSVQSDIWSMGLSLVEMAV-GRYP---------------IPPP-DAKELELMF-GCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI--
---YQNLSPVGSGAYGSVCAAFDT----KTGLRVAVKKL---SRP--F-QSIIH--AKRTYR-ELRLLKHMKHENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK-CQ----KLTDDHVQFLIYQILRGLKYIHS-ADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FPGT-DHIDQLKLI-LRLVGTPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF--
--L-RLLEKLGDGSFGVVRRGEWD-APSGKTVSVAVKCL---K-PDVL-SQ-PEAMDDFI-R-EVNAMHSLDHRNLIRLYGVVL---------TPPMKMVTELAPLGSLLDRLR-KH--QGHFLLGTLSRYAVQVAEGMGYLES-KRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQN--DDHYVMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEP---------------WIGL-NGSQILHKIDKEGERLPRPEDCP-------------------------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L--
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