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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK TNK2 203
TK ABL1 261
TK ALK 1116
Other AURKA 133
TK BLK 241
TK BTK 402
CMGC CDC2 4
CMGC CDK2 4
TK CSK 195
TK EGFR 712
TK EPHB4 615
TK ERBB2 720
TK FGFR1 478
TK FYN 271
TK INSR 1023
TKL IRAK4 186
TK ITK 363
TK JAK2 849
TK JAK3 822
TK KIT 589
TK LCK 245
TK LYN 247
TK MET 1078
TK PDGFRB 600
AGC PRKCD 349
AGC PRKCQ 380
TKL RAF1 349
TK RET 724
TK SRC 270
TK SYK 371
TK TEK 824
TK TNK1 116
TK YES1 277
TK ZAP70 338
---L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCL---K-PDVL-SQ-PEA-MD-DFI-R-EVNAMHSL--DHRNLIRLYGVVL---TPPMKMVTELAPLGSLLDRLR----KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLAT---RDLVKIGDFGLMRAL--PQ-N--DDHY--VMQEHRKVPFAWCAPESLK-TRT---FSHASDTWMFGVTLWEMFTYGQEP---------------WIGL-NGSQILHKIDKEGER----LPRPEDCP----------------------------QDIYN-VMVQCWAHKPEDRPT-FV-ALRDF--L---
----ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTL---K-E--D-TM-EV---E-EFL-K-EAAVMKEI--KHPNLVQLLGVCT--REPPFYIITEFMTYGNLLDYLR----EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKVADFGLSRLM-----T--GDTY--TAHAGAKFPIKWTAPESLA-YNK---FSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELL-EKDYR----MERPEGCP----------------------------EKVYE-LMRACWQWNPSDRPS-FA-EIHQA--F---
---I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTL---P-E--V-CS-EQD-EL-DFL-M-EALIISKF--NHQNIVRCIGVSL--QSLPRFILLELMAGGDLKSFLR----ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI---Y-R--ASYY--RKGGCAMLPVKWMPPEAFM-EGI---FTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK-SNQEVLEFV-TSGGR----MDPPKNCP----------------------------GPVYR-IMTQCWQHQPEDRPN-FA-IILER--I---
----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVL---FKA--QLEKAGV---E-HQLRR-EVEIQSHL--RHPNILRLYGYFH--DATRVYLILEYAPLGTVYRELQ---KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS---AGELKIADFGWSV-------HAPSSRR--TT---LCGTLDYLPPEMIE-GRM---HDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETY-KRISR----VEFTFPDFVT--------------------------EGARD-LISRLLKHNPSQRPM-LR-EVLEHPWI---
---L-RLVRKLGSGQFGEVWMGYYK--------NNMKVAIKTL---K-E--G-TM-SP---E-AFL-G-EANVMKAL--QHERLVRLYAVVT---KEPIYIVTEYMARGCLLDFLK----TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSE---ALCCKIADFGLARII--------DSEY--TAQEGAKFPIKWTAPEAIH-FGV---FTIKADVWSFGVLLMEVVTYGRVP---------------YPGM-SNPEVIRNL-ERGYR----MPRPDTCP----------------------------PELYRGVIAECWRSRPEERPT-FE-FLQSV--L---
----LTFLKELGTGQFGVVKYGKWR--------GQYDVAIKMI---K-E--G-SM-SE---D-EFI-E-EAKVMMNL--SHEKLVQLYGVCT--KQRPIFIITEYMANGCLLNYLR----EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVND---QGVVKVSDFGLSRYV-----L--DDEY--TSSVGSKFPVRWSPPEVLM-YSK---FSSKSDIWAFGVLMWEIYSLGKMP---------------YERF-TNSETAEHI-AQGLR----LYRPHLAS----------------------------EKVYT-IMYSCWHEKADERPT-FK-ILLSN--I---
----YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKI---RLE--S-EEEGV---P-STAIR-EISLLKEL--RHPNIVSLQDVLM--QDSRLYLIFEFLSM-DLKKYLDSIPPGQ----------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAF-----GIPIRVY--TH---EVVTLWYRSPEVLLGSAR---YSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRI-FRALG----TPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-GK-MALNHPYF---
----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKI---RLD--T-ETEGV---P-STAIR-EISLLKEL--NHPNIVKLLDVIH--TENKLYLVFEFLHQ-DLKKFMDA-SALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAF-----GVPVRTY--TH---EVVTLWYRAPEILLGCKY---YSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRI-FRTLG----TPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-AK-AALAHPFF---
----LKLLQTIGKGEFGDVMLGDYR---------GNKVAVKCI---K-N--D-AT-AQ-----AFL-A-EASVMTQL--RHSNLVQLLGVIV-EEKGGLYIVTEYMAKGSLVDYLR----SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSE---DNVAKVSDFGLTKEA-----------S--STQDTGKLPVKWTAPEALR-EKK---FSTKSDVWSFGILLWEIYSFGRVP---------------YPRI-PLKDVVPRV-EKGYK----MDAPDGCP----------------------------PAVYE-VMKNCWHLDAAMRPS-FL-QLREQL-----
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKEL---R-E--A-TS-PKA-NK-EIL-D-EAYVMASV--DNPHVCRLLGICL---TSTVQLITQLMPFGCLLDYVR----EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL---G-A--EEKE--YHAEGGKVPIKWMALESIL-HRI---YTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSIL-EKGER----LPQPPICT----------------------------IDVYM-IMVKCWMIDADSRPK-FR-ELI----IEF-
---V-KIEEVIGAGEFGEVCRGRLK----APGKKESCVAIKTL---K-G--G-YT-ERQ-RR-EFL-S-EASIMGQF--EHPNIIRLEGVVT--NSMPVMILTEFMENGALDSFLR----LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNS---NLVCKVSDFGLSRFLEENS-S--DPTY--TSSLGGKIPIRWTAPEAIA-FRK---FTSASDAWSYGIVMWEVMSFGERP---------------YWDM-SNQDVINAI-EQDYR----LPPPPDCP----------------------------TSLHQ-LMLDCWQKDRNARPR-FP-QVVSAL-----
---L-RKVKVLGSGAFGTVYKGIWIP---DGENVKIPVAIKVL---R-E--N-TS-PKA-NK-EIL-D-EAYVMAGV--GSPYVSRLLGICL---TSTVQLVTQLMPYGCLLDHVR----EN--------------------------------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKS---PNHVKITDFGLARLL---D-I--DETE--YHADGGKVPIKWMALESIL-RRR---FTHQSDVWSYGVTVWELMTFGAKP---------------YDGI-PAREIPDLL-EKGER----LPQPPICT----------------------------IDVYM-IMVKCWMIDSECRPR-FR-ELVSE--F---
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML---K-S--D-AT-EKD-LS-DLI-S-EMEMMKMIG-KHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLQ----ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI---H-H--IDYY--KKTTNGRLPVKWMAPEALF-DRI---YTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-PVEELFKLL-KEGHR----MDKPSNCT----------------------------NELYM-MMRDCWHAVPSQRPT-FK-QLVEDL-----
----LQLIKRLGNGQFGEVWMGTWN--------GNTKVAIKTL---K-P--G-TM-SP---E-SFL-E-EAQIMKKL--KHDKLVQLYAVVS---EEPIYIVTEYMNKGSLLDFLK----DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGN---GLICKIADFGLARLI-----E--DNEY--TARQGAKFPIKWTAPEAAL-YGR---FTIKSDVWSFGILLTELVTKGRVP---------------YPGM-NNREVLEQV-ERGYR----MPCPQDCP----------------------------ISLHE-LMIHCWKKDPEERPT-FE-YLQSFL-----
----ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTV---N-E--S-AS-LRE-RI-EFL-N-EASVMKGF--TCHHVVRLLGVVS--KGQPTLVVMELMAHGDLKSYLR----SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI---Y-E--TDYY--RKGGKGLLPVRWMAPESLK-DGV---FTTSSDMWSFGVVLWEITSLAEQP---------------YQGL-SNEQVLKFV-MDGGY----LDQPDNCP----------------------------ERVTD-LMRMCWQFNPKMRPT-FL-EIVNLL-----
-VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKL---AAM--V-DITTE---ELKQQFDQEIKVMAKC--QHENLVELLGFSS--DGDDLCLVYVYMPNGSLLDRLSCLDGTP----------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDE---AFTAKISDFGLARASE---KFAQTVMT--SR---IVGTTAYMAPEALR--GE---ITPKSDIYSFGVVLLEIIT-GLPA---------------VDEH-REPQLLLDI-KEEIE----DEEKTIEDYIDKKMNDAD--------------STSVEAMYS-VASQCLHEKKNKRPD-IK-KVQQ----LLQ
----LTFVQEIGSGQFGLVHLGYWL--------NKDKVAIKTI---R-E--G-AM-SE---E-DFI-E-EAEVMMKL--SHPKLVQLYGVCL--EQAPICLVFEFMEHGCLSDYLR----TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGE---NQVIKVSDFGMTRFV-----L--DDQY--TSSTGTKFPVKWASPEVFS-FSR---YSSKSDVWSFGVLMWEVFSEGKIP---------------YENR-SNSEVVEDI-STGFR----LYKPRLAS----------------------------THVYQ-IMNHCWKERPEDRPA-FS-RLLRQL-----
----LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKL---Q-H--S-TE--EH-LR-DFE-R-EIEILKSL--QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ----KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN---ENRVKIGDFGLTKVL--PQ-D--KEYY--KVKEPGESPIFWYAPESLT-ESK---FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELL-KNNGR----LPRPDGCP----------------------------DEIYM-IMTECWNNNVNQRPS-FR-DLA----LRV-
---L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAVKQL---Q-H--S-GP-DQ--QR-DFQ-R-EIQILKAL--HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ----RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVES---EAHVKIADFGLAKLL--PL-D--KDYY--VVREPGQSPIFWYAPESLS-DNI---FSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELL-EEGQR----LPAPPACP----------------------------AEVHE-LMKLCWAPSPQDRPS-FS-ALGP---QL--
----LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKML---K-P--S-AH-LTE-RE-ALM-S-ELKVLSYLG-NHMNIVNLLGACT--IGGPTLVITEYCCYGDLLNFLR----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH---GRITKICDFGLARDI---K-N--DSNY--VVKGNARLPVKWMAPESIF-NCV---YTFESDVWSYGIFLWELFSLGSSP---------------YPGMPVDSKFYKMI-KEGFR----MLSPEHAP----------------------------AEMYD-IMKTCWDADPLKRPT-FK-QIVQL--I---
----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSL---K-Q--G-SM-SP---D-AFL-A-EANLMKQL--QHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLK----TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI-----E--DNEY--TAREGAKFPIKWTAPEAIN-YGT---FTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNL-ERGYR----MVRPDNCP----------------------------EELYQ-LMRLCWKERPEDRPT-FD-YLRSV--L---
----IKLVKRLGAGQFGEVWMGYYN--------NSTKVAVKTL---K-P--G-TM-SV---Q-AFL-E-EANLMKTL--QHDKLVRLYAVVT--REEPIYIITEYMAKGSLLDFLK----SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSE---SLMCKIADFGLARVI-----E--DNEY--TAREGAKFPIKWTAPEAIN-FGC---FTIKSDVWSFGILLYEIVTYGKIP---------------YPGR-TNADVMTAL-SQGYR----MPRVENCP----------------------------DELYD-IMKMCWKEKAEERPT-FD-YLQSV--L---
----VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSL---N-R--I-TD-IGE-VS-QFL-T-EGIIMKDF--SHPNVLSLLGICL-RSEGSPLVVLPYMKHGDLRNFIR----NE--------------------------------------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDE---KFTVKVADFGLARDM---Y-D--KEYYSVHNKTGAKLPVKWMALESLQ-TQK---FTTKSDVWSFGVLLWELMTRGAPP---------------YPDV-NTFDITVYL-LQGRR----LLQPEYCP----------------------------DPLYE-VMLKCWHPKAEMRPS-FS-ELVSR--I---
---L-VLGRTLGSGAFGQVVEATAHG--LSHSQATMKVAVKML---K-S--T-AR-SSE-KQ-ALM-S-ELKIMSHLG-PHLNVVNLLGACT--KGGPIYIITEYCRYGDLVDYLH----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICE---GKLVKICDFGLARDI---M-R--DSNY--ISKGSTFLPLKWMAPESIF-NSL---YTTLSDVWSFGILLWEIFTLGGTP---------------YPELPMNEQFYNAI-KRGYR----MAQPAHAS----------------------------DEIYE-IMQKCWEEKFEIRPP-FS-QLVL---LL--
--FI--FHKVLGKGSFGKVLLGELK-------GRGEYFAIKAL---KKD--V-VLIDD---D-VECTMVEKRVLTLA-AENPFLTHLICTFQ--TKDHLFFVMEFLNGGDLMYHIQ---DKG----------------------------------------------------------------------------------------------------RFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDR---DGHIKIADFGMCKEN-----IFGESRA--ST---FCGTPDYIAPEILQ-GLK---YTFSVDWWSFGVLLYEMLI-GQSP---------------FHGD----DEDELF-ESIRV----DTPHYPRWIT--------------------------KESKD-ILEKLFEREPTKRLGVTG-NIKIHPFF---
--FI--LHKMLGKGSFGKVFLAEFK-------KTNQFFAIKAL---KKD--V-VLMDD---D-VECTMVEKRVLSLA-WEHPFLTHMFCTFQ--TKENLFFVMEYLNGGDLMYHIQ---SCH----------------------------------------------------------------------------------------------------KFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDK---DGHIKIADFGMCKEN-----MLGDAKT--NT---FCGTPDYIAPEILL-GQK---YNHSVDWWSFGVLLYEMLI-GQSP---------------FHGQ----DEEELF-HSIRM----DNPFYPRWLE--------------------------KEAKD-LLVKLFVREPEKRLG-VRGDIRQHPLF---
--VM--LSTRIGSGSFGTVYKGKWH----------GDVAVKIL---K-V-VD-PT-PEQ-FQ-AFR-N-EVAVLRKT--RHVNILLFMGYMT---KDNLAIVTQWCEGSSLYKHLH----VQ--------------------------------------------------------------------------------------------------ETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHE---GLTVKIGDFGLATVK---S-R--WSGS--QQVEQPTGSVLWMAPEVIR-MQDNNPFSFQSDVYSYGIVLYELMT-GELP---------------YSHINNRDQIIFMV-GRGYASPDLSKLYKNCP----------------------------KAMKR-LVADCVKKVKEERPL-FP-QILSS--I---
---L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKML---K-E--N-AS-PSE-LR-DLL-S-EFNVLKQV--NHPHVIKLYGACS--QDGPLLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV---Y-E--EDSY--VKRSQGRIPVKWMAIESLF-DHI---YTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-PPERLFNLL-KTGHR----MERPDNCS----------------------------EEMYR-LMLQCWKQEPDKRPV-FA-DISKDL-----
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTL---K-P--G-TM-SP---E-AFL-Q-EAQVMKKL--RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLK----GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI-----E--DNEY--TARQGAKFPIKWTAPEAAL-YGR---FTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQV-ERGYR----MPCPPECP----------------------------ESLHD-LMCQCWRKEPEERPT-FE-YLQAF--L---
-TLE---DKELGSGNFGTVKKGYYQ-----MKKVVKTVAVKIL---K-N--E-AN-DPALKD-ELL-A-EANVMQQL--DNPYIVRMIGICE---AESWMLVMEMAELGPLNKYLQ----QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT---QHYAKISDFGLSKAL---R-A--DENY-YKAQTHGKWPVKWYAPECIN-YYK---FSSKSDVWSFGVLMWEAFSYGQKP---------------YRGM-KGSEVTAML-EKGER----MGCPAGCP----------------------------REMYD-LMNLCWTYDVENRPG-FA-AVE----LRL-
----IKFQDVIGEGNFGQVLKARIK-----KDGLRMDAAIKRM---K-E--Y-AS-KDD-HR-DFA-G-ELEVLCKLG-HHPNIINLLGACE--HRGYLYLAIEYAPHGNLLDFLR----KSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE---NYVAKIADFGLSRGQ---------EVY--VKKTMGRLPVRWMAIESLN-YSV---YTTNSDVWSYGVLLWEIVSLGGTP---------------YCGM-TCAELYEKL-PQGYR----LEKPLNCD----------------------------DEVYD-LMRQCWREKPYERPS-FA-QILV---SL--
-VCR---GELLGSGCFGVVHRGLWT----LPSGKSVPVAVKSLRVGP-E--G-PM-GTE-LG-DFL-R-EVSVMMNL--EHPHVLRLHGLVL---GQPLQMVMELAPLGSLHARLT----AP------------------------------------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLAS---PRTIKVADFGLVRPL--GG-A--RGRY--VMGGPRPIPYAWCAPESLR-HGA---FSSASDVWMFGVTLWEMFSGGEEP---------------WAGV-PPYLILQRL-EDRAR----LPRPPLCS----------------------------RALYS-LALRCWAPHPADRPS-FS-HLE----GLL-
---L-RLEVKLGQGCFGEVWMGTWN--------GTTKVAIKTL---K-P--G-TM-MP---E-AFL-Q-EAQIMKKL--RHDKLVPLYAVVS---EEPIYIVTEFMSKGSLLDFLK----EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGE---NLVCKIADFGLARLI-----E--DNEY--TARQGAKFPIKWTAPEAAL-YGR---FTIKSDVWSFGILQTELVTKGRVP---------------YPGM-VNREVLEQV-ERGYR----MPCPQGCP----------------------------ESLHE-LMNLCWKKDPDERPT-FE-YIQSFL-----
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVL---K-Q--G-TE-KAD-TE-EMM-R-EAQIMHQL--DNPYIVRLIGVCQ---AEALMLVMEMAGGGPLHKFLV----GK--------------------------------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKAL--GA-D--DSYY--TARSAGKWPLKWYAPECIN-FRK---FSSRSDVWSYGVTMWEALSYGQKP---------------YKKM-KGPEVMAFI-EQGKR----MECPPECP----------------------------PELYA-LMSDCWIYKWEDRPD-FL-TVEQR--M---
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