|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK YES1 203
TK ABL1 261
CMGC CDK2 4
CMGC CDK4 6
TK FGFR2 481
TK FYN 271
TK LCK 245
TK MET 1078
TK PTK2 422
TK SRC 270
TK TNK2 150
L-RLEVKLGQGCFGEVWMGTWN--------GTTKVAIKTLK-P--GTM----MP--EAFL-QEAQIMKKL-R---HDKLVPLYAVVS-------EEPIYIVTEFMSKGSLLDFLK---EG--------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLI--E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQV-ERGYRMPCPQGCP----------------------------ESLHELMNLCWKKDPDERPTFEYIQSFL--
-ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E--DTM----EV--EEFL-KEAAVMKEI-K---HPNLVQLLGVCT-R-----EPPFYIITEFMTYGNLLDYLR---EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--T--GDTY--TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELL-EKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F
-FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLD--TETE---GV--PSTAIREISLLKEL-N---HPNIVKLLDVIH-T-----ENKLYLVFEFLHQ-DLKKFMDASALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTY--TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
Y-EPVAEIGVGAYGTVYKARDP-------HSGHFVALKSVRVP--NGGGGGGGL--PISTVREVALLRRL-EAFEHPNVVRLMDVCA-TSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPP-----------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI---YSYQMAL--TP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPR--PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
-LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-D--DAT----EKDLSDLV-SEMEMMKMIGK---HKNIINLLGACT-Q-----DGPLYVIVEYASKGNLREYLR---ARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI-NN--IDYY--KKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL-KEGHRMDKPANCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL--
-LQLIKRLGNGQFGEVWMGTWN--------GNTKVAIKTLK-P--GTM----SP--ESFL-EEAQIMKKL-K---HDKLVQLYAVVS-------EEPIYIVTEYMNKGSLLDFLK---DG--------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI--E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQV-ERGYRMPCPQDCP----------------------------ISLHELMIHCWKKDPEERPTFEYLQSFL--
-LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q--GSM----SP--DAFL-AEANLMKQL-Q---HQRLVRLYAVVT-------QEPIYIITEYMENGSLVDFLK---TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--E--DNEY--TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL-ERGYRMVRPDNCP----------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L
-VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSLN-R--ITD----IGEVSQFL-TEGIIMKDF-S---HPNVLSLLGICLRS-----EGSPLVVLPYMKHGDLRNFIR---NE---------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDM-YD--KEYYSVHNKTGAKLPVKWMALESLQ-TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYL-LQGRRLLQPEYCP----------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I
-IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-N--CTS----DSVREKFL-QEALTMRQF-D---HPHIVKLIGVIT-------ENPVWIIMELCTLGELRSFLQ---VR---------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM--E--DSTY--YKASKGKLPIKWMAPESIN-FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI-ENGERLPMPPNCP----------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL--
L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P--GTM----SP--EAFL-QEAQVMKKL-R---HEKLVQLYAVVS-------EEPIYIVTEYMSKGSLLDFLK---GE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECP----------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L
L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVLSQ----PEAMDDFI-REVNAMHSL-D---HRNLIRLYGVVL-------TPPMKMVTELAPLGSLLDRLR---KH---------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQN--DDHY--VMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCP----------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L
|