Kinase profiling results of kinases in KIF 2HW7A_STU (MKNK2, PDB code: 2HW7, chain A)
Template Kinase: MKNK2
Template inhibitor: staurosporine

 28 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C
CDC42BPA1  
CDC42BPB1  
CDC42BPG1  
DMPKAGC  
PRKCDAGC  
PRKCQAGC  
PKN2AGC  
RPS6KB1AGC  
CAMK2DCAMK  
CAMK2GCAMK  
CHEK1CAMK  
DAPK1CAMK  
DAPK2CAMK  
STK17ACAMK  
STK17BCAMK  
MAPKAPK23  
MKNK2CAMK  
PHKG1CAMK  
PHKG2CAMK  
PRKD1CAMK  
PRKD2CAMK  
PRKD3CAMK  
CHEK2CAMK  
SBK1Other  
STK36Other  
SLKSTE  
STK10STE  

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C
CDC42BPAAGC    
CDC42BPBAGC    
DMPKAGC    
PKN2AGC    
PRKCDAGC    
PRKCQAGC    
RPS6KB1AGC    
RPS6KB2AGC    
CAMK2DCAMK    
CAMK2GCAMK    
CHEK1CAMK    
CHEK2CAMK    
DAPK1CAMK    
DAPK2CAMK    
MAPKAPK2CAMK    
MKNK2CAMK    
PHKG1CAMK    
PHKG2CAMK    
PRKD1CAMK    
PRKD2CAMK    
PRKD3CAMK    
STK17ACAMK    
SLKSTE    
STK10STE