Kinase profiling results of kinases in KIF 2HY81_1ST (PAK1, PDB code: 2HY8, chain 1)
Template Kinase: PAK1
Template inhibitor: UCN 02

 57 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C
PDPK1AGC  
PRKCHAGC  
CHEK1CAMK  
STK17ACAMK  
STK17BCAMK  
MAPKAPK23  
PIM1CAMK  
PIM3CAMK  
PRKD1CAMK  
PRKD2CAMK  
PRKD3CAMK  
CHEK2CAMK  
CDK2CMGC  
CDK3CMGC  
CDK5CMGC  
CDK8CMGC  
CDK9CMGC  
CDC2L5CMGC  
CDKL1CMGC  
CDKL2CMGC  
CDKL3CMGC  
CDKL5CMGC  
GSK3ACMGC  
GSK3BCMGC  
MAPK1CMGC  
MAPK8CMGC  
NLKCMGC  
ICKCMGC  
MAKCMGC  
SBK1Other  
STK35Other  
TLK2Other  
MAP3K15STE  
MAP3K5STE  
MAP3K6STE  
MAP3K1STE  
YSK4STE  
MAP3K2STE  
MAP3K3STE  
MAP3K4STE  
PAK1STE  
PAK2STE  
PAK3STE  
PAK6STE  
STK24STE  
EGFRTK  
FESTK  
FGFR1TK  
FGFR3TK  
JAK2TK  
ITKTK  
TECTK  
TXKTK  
IRAK4TKL  

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C
PDPK1AGC  
PRKCBAGC  
PRKCBAGC  
PRKCHAGC  
CHEK1CAMK  
CHEK2CAMK  
MAPKAPK2CAMK  
PIM1CAMK  
PIM3CAMK  
PRKD1CAMK  
PRKD2CAMK  
PRKD3CAMK  
STK17ACAMK  
CDC2CMGC  
CDC2CMGC  
CDK2CMGC  
CDK3CMGC  
CDK5CMGC  
CDK6CMGC  
CDK6CMGC  
CDK9CMGC  
GSK3ACMGC  
GSK3BCMGC  
MAPK1CMGC  
MAPK8CMGC  
NLKCMGC  
TLK2Other  
MAP3K2STE  
MAP3K3STE  
MAP3K5STE  
PAK1STE  
PAK2STE  
PAK3STE  
PAK6STE  
STK24STE  
EGFRTK  
FESTK  
FGFR1TK  
FGFR3TK  
ITKTK  
JAK2TK  
TECTK  
TXKTK  
IRAK4TKL