Kinase profiling results of kinases in KIF 3Q4TA_TAK (ACVR2A, PDB code: 3Q4T, chain A)
Template Kinase: ACVR2A
Template inhibitor: dorsomorphin

6 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C
RAF1TKL   
ACVR1TKL   
ACVRL1TKL   
TGFBR1TKL   
ACVR2ATKL   
TGFBR2TKL   

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C
ACVR1TKL    
ACVRL1TKL    
RAF1TKL    
TGFBR1TKL    
TGFBR2TKL