Kinase profiling results of kinases in KIF 2XBAA_571 (ALK, PDB code: 2XBA, chain A)
Template Kinase: ALK
Template inhibitor: 5-Amido-pyrrolopyrazole 9b

17 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C
AURKAOther   
AURKBOther   
AURKCOther   
ABL1TK   
ALKTK   
FGFR1TK   
IGF1RTK   
INSRTK   
JAK2TK   
JAK3TK   
CSF1RTK   
RETTK   
SRCTK   
HCKTK   
LCKTK   
ITKTK   
NTRK1TK   

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C
AURKAOther  
AURKBOther  
AURKCOther  
ABL1TK  
ALKTK  
CSF1RTK  
FGFR1TK  
HCKTK  
IGF1RTK  
INSRTK  
ITKTK  
JAK2TK  
JAK3TK  
LCKTK  
NTRK1TK  
RETTK  
SRCTK