Kinase profiling results of kinases in KIF 2W1EA_L0E (AURKA, PDB code: 2W1E, chain A)
Template Kinase: AURKA
Template inhibitor: pyrazole-benzimidazole urea analogue, 10

 15 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C
PRKCDAGC 
PRKCQAGC 
CHEK1CAMK 
CDK2CMGC 
GSK3BCMGC 
AURKAOther 
AURKBOther 
ABL1TK 
EGFRTK 
JAK2TK 
JAK3TK 
RETTK 
LCKTK 

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
PRKCDAGC
PRKCQAGC
PRKCZAGC
CHEK1CAMK
CDC2CMGC
CDC2CMGC
CDK2CMGC
GSK3BCMGC
AURKAOther
AURKBOther
ABL1TK
EGFRTK
JAK2TK
JAK3TK
LCKTK
RETTK