Kinase profiling results of kinases in KIF 2XNEA_ASH (AURKA, PDB code: 2XNE, chain A)
Template Kinase: AURKA
Template inhibitor: CAS866405_64_3

 15 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
CDK2CMGC
CDK4CMGC
MAPK10CMGC
MAPK9CMGC
AURKAOther
AURKCOther
ABL1TK
EGFRTK
FGFR2TK
JAK2TK
RETTK
LCKTK
IRAK4TKL
BRAFTKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
CDC2CMGC
CDC2CMGC
CDK2CMGC
CDK4CMGC
MAPK10CMGC
MAPK9CMGC
AURKAOther
AURKCOther
ABL1TK
EGFRTK
FGFR2TK
JAK2TK
LCKTK
RETTK
BRAFTKL
IRAK4TKL