Kinase profiling results of kinases in KIF 3H0ZA_45B (AURKA, PDB code: 3H0Z, chain A)
Template Kinase: AURKA
Template inhibitor: 2,4-Bisanilinopyrimidine, 9

12 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C C C
PDPK1AGC      
MAPK10CMGC      
MAPK8CMGC      
AURKAOther      
AURKBOther      
ABL1TK      
ALKTK      
EGFRTK      
JAK3TK      
LCKTK      
TEKTK      
BRAFTKL      

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C C C
PDPK1AGC       
MAPK10CMGC       
MAPK8CMGC       
AURKAOther       
AURKBOther       
ABL1TK       
ALKTK       
EGFRTK       
JAK3TK       
LCKTK       
TEKTK       
BRAFTKL