Kinase profiling results of kinases in KIF 3NRMA_NRM (AURKA, PDB code: 3NRM, chain A)
Template Kinase: AURKA
Template inhibitor: CAS404828_08_6

 32 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
CHEK1CAMK
NUAK1CAMK
DAPK1CAMK
CHEK2CAMK
CDK2CMGC
CDK4CMGC
CSNK2A1CMGC
CSNK2A2CMGC
GSK3ACMGC
GSK3BCMGC
AURKAOther
AURKBOther
PLK3Other
MAP4K2STE
SLKSTE
ABL2TK
TNK2TK
EGFRTK
FERTK
FGFR1TK
RETTK
LCKTK
SYKTK
ZAP70TK
BMXTK
BTKTK
ITKTK
TXKTK
NTRK1TK
NTRK2TK
NTRK3TK
IRAK4TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
CHEK1CAMK 
CHEK2CAMK 
DAPK1CAMK 
NUAK1CAMK 
CDK2CMGC 
CDK4CMGC 
CSNK2A1CMGC 
CSNK2A2CMGC 
GSK3ACMGC 
GSK3BCMGC 
AURKAOther 
AURKBOther 
PLK3Other 
MAP4K2STE 
SLKSTE 
ABL2TK 
BMXTK 
BTKTK 
EGFRTK 
FERTK 
FGFR1TK 
ITKTK 
LCKTK 
NTRK1TK 
NTRK2TK 
NTRK3TK 
RETTK 
SYKTK 
TNK2TK 
TXKTK 
ZAP70TK 
IRAK4TKL