Kinase profiling results of kinases in KIF 3R21A_D36 (AURKA, PDB code: 3R21, chain A)
Template Kinase: AURKA
Template inhibitor: VX_680

 5 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C
CDK2CMGC  
CDK4CMGC  
AURKAOther  
ALKTK  

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
CDC2CMGC 
CDC2CMGC 
CDK2CMGC 
CDK4CMGC 
AURKAOther 
ALKTK