Kinase profiling results of kinases in KIF 3D4QA_SM5 (BRAF, PDB code: 3D4Q, chain A)
Template Kinase: BRAF
Template inhibitor: pyrazole based inhibitor, 18

2 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C
BRAFTKL 
RAF1TKL 

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
BRAFTKL
RAF1TKL