Kinase profiling results of kinases in KIF 3PIXA_027 (BTK, PDB code: 3PIX, chain A)
Template Kinase: BTK
Template inhibitor: 7-(4-Methylpiperazin-1-Yl)-4-[(5-Methyl-1h-Pyrazol-3-Yl)amino]-2-(Propan-2-Yl)phthalazin-1(2h)-One

 15 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C
AURKAOther 
AURKBOther 
ABL1TK 
ALKTK 
EGFRTK 
FGFR3TK 
JAK2TK 
KITTK 
PDGFRBTK 
SRCTK 
SYKTK 
BTKTK 
ITKTK 
KDRTK 

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
CDC2CMGC 
CDC2CMGC 
AURKAOther 
AURKBOther 
ABL1TK 
ALKTK 
BTKTK 
EGFRTK 
FGFR3TK 
ITKTK 
JAK2TK 
KDRTK 
KITTK 
PDGFRBTK 
SRCTK 
SYKTK