Kinase profiling results of kinases in KIF 3PJ1A_LHL (BTK, PDB code: 3PJ1, chain A)
Template Kinase: BTK
Template inhibitor: AZD_1152HQPA

 30 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C C C C C
ABL1TK        
ALKTK        
EGFRTK        
EPHB1TK        
EPHB4TK        
FGFR2TK        
FGFR3TK        
FGFR4TK        
IGF1RTK        
INSRTK        
JAK2TK        
TYK2TK        
METTK        
KITTK        
PDGFRATK        
PDGFRBTK        
RETTK        
ROS1TK        
FYNTK        
SRCTK        
YES1TK        
HCKTK        
LCKTK        
LYNTK        
SYKTK        
BMXTK        
BTKTK        
NTRK2TK        
FLT4TK        
KDRTK        

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
ABL1TK 
ALKTK 
BMXTK 
BTKTK 
EGFRTK 
EPHB1TK 
EPHB4TK 
FGFR2TK 
FGFR3TK 
FGFR4TK 
FLT4TK 
FYNTK 
HCKTK 
IGF1RTK 
INSRTK 
JAK2TK 
KDRTK 
KITTK 
LCKTK 
LYNTK 
METTK 
NTRK2TK 
PDGFRATK 
PDGFRBTK 
RETTK 
ROS1TK 
SRCTK 
SYKTK 
TYK2TK 
YES1TK