Kinase profiling results of kinases in KIF 1URWA_I1P (CDK2, PDB code: 1URW, chain A)
Template Kinase: CDK2
Template inhibitor: Imidazo[1,2-b]pyridazine deriv. 2e

12 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C
CDK2CMGC  
CDK4CMGC  
GSK3BCMGC  
MAPK10CMGC  
AURKAOther  
AURKBOther  
CHUKOther  
PLK1Other  
ABL1TK  
SRCTK  
LCKTK  

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C
CDC2CMGC   
CDC2CMGC   
CDK2CMGC   
CDK4CMGC   
GSK3BCMGC   
MAPK10CMGC   
AURKAOther   
AURKBOther   
CHUKOther   
PLK1Other   
ABL1TK   
LCKTK   
SRCTK