Kinase profiling results of kinases in KIF 3DDPA_RC8 (CDK2, PDB code: 3DDP, chain A)
Template Kinase: CDK2
Template inhibitor: Roscovitine

 42 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
AKT1AGC
AKT2AGC
PRKCDAGC
PRKCQAGC
RPS6KA1AGC
RPS6KA1CAMK
RPS6KA2AGC
RPS6KA2CAMK
CHEK1CAMK
STK33CAMK
DAPK1CAMK
CDK2CMGC
CDK3CMGC
CDK4CMGC
CDK5CMGC
CDK9CMGC
PCTK1CMGC
CLK1CMGC
CLK2CMGC
CLK4CMGC
DYRK1ACMGC
DYRK1BCMGC
GSK3BCMGC
MAPK1CMGC
MAPK10CMGC
MAPK8CMGC
MAPK9CMGC
CAMKK2Other
TTKOther
ABL1TK
ABL2TK
TNK2TK
FGFR1TK
JAK2TK
JAK3TK
FGRTK
FYNTK
SRCTK
YES1TK
NTRK2TK
NTRK3TK
MAP3K11TKL
MAP3K9TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C
AKT1AGC     
AKT2AGC     
PRKCDAGC     
PRKCQAGC     
RPS6KA1AGC     
RPS6KA2AGC     
CHEK1CAMK     
DAPK1CAMK     
STK33CAMK     
CDC2CMGC     
CDC2CMGC     
CDK2CMGC     
CDK3CMGC     
CDK4CMGC     
CDK5CMGC     
CDK9CMGC     
CLK1CMGC     
CLK2CMGC     
CLK4CMGC     
DYRK1ACMGC     
DYRK1BCMGC     
GSK3BCMGC     
MAPK1CMGC     
MAPK10CMGC     
MAPK8CMGC     
MAPK9CMGC     
CAMKK2Other     
TTKOther     
ABL1TK     
ABL2TK     
FGFR1TK     
FGRTK     
FYNTK     
JAK2TK     
JAK3TK     
NTRK2TK     
NTRK3TK     
SRCTK     
TNK2TK     
YES1TK     
MAP3K11TKL     
MAP3K9TKL