Kinase profiling results of kinases in KIF 2EUFB_LQQ (CDK6, PDB code: 2EUF, chain B)
Template Kinase: CDK6
Template inhibitor: Pyrido-[2,3-d]-pyrimidin-7-one 33

13 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
CDK2CMGC
CDK4CMGC
MAPK11CMGC
MAPK14CMGC
AURKAOther
PLK2Other
PLK3Other
FGFR1TK
FGFR3TK
INSRTK
JAK2TK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
CDC2CMGC
CDC2CMGC
CDK2CMGC
CDK4CMGC
CDK6CMGC
CDK6CMGC
MAPK11CMGC
MAPK14CMGC
AURKAOther
PLK2Other
PLK3Other
FGFR1TK
FGFR3TK
INSRTK
JAK2TK