Kinase profiling results of kinases in KIF 2F2CB_AP9 (CDK6, PDB code: 2F2C, chain B)
Template Kinase: CDK6
Template inhibitor: MLS000911551

 24 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
CDK2CMGC
CDK3CMGC
CDK4CMGC
CDK5CMGC
CDK9CMGC
PCTK1CMGC
CLK1CMGC
CLK4CMGC
DYRK1ACMGC
DYRK1BCMGC
GSK3BCMGC
MAPK1CMGC
MAPK10CMGC
MAPK14CMGC
EIF2AK2Other
PLK3Other
TTKOther
SLKSTE
ABL1TK
INSRTK
MUSKTK
NTRK2TK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C
CDC2CMGC     
CDC2CMGC     
CDK2CMGC     
CDK3CMGC     
CDK4CMGC     
CDK5CMGC     
CDK6CMGC     
CDK6CMGC     
CDK9CMGC     
CLK1CMGC     
CLK4CMGC     
DYRK1ACMGC     
DYRK1BCMGC     
GSK3BCMGC     
MAPK1CMGC     
MAPK10CMGC     
MAPK14CMGC     
PLK3Other     
TTKOther     
SLKSTE     
ABL1TK     
INSRTK     
MUSKTK     
NTRK2TK