Kinase profiling results of kinases in KIF 3NUPA_3NU (CDK6, PDB code: 3NUP, chain A)
Template Kinase: CDK6
Template inhibitor: INCB18424

 15 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C
CHEK1CAMK 
CDK2CMGC 
CDK4CMGC 
CSNK2A1CMGC 
GSK3BCMGC 
MAPK10CMGC 
MAPK8CMGC 
MAPK9CMGC 
MAPK11CMGC 
MAPK12CMGC 
MAPK13CMGC 
MAPK14CMGC 
JAK2TK 

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
CHEK1CAMK
CDC2CMGC
CDC2CMGC
CDK2CMGC
CDK4CMGC
CDK6CMGC
CDK6CMGC
CSNK2A1CMGC
GSK3BCMGC
MAPK10CMGC
MAPK11CMGC
MAPK12CMGC
MAPK13CMGC
MAPK14CMGC
MAPK8CMGC
MAPK9CMGC
JAK2TK