Kinase profiling results of kinases in KIF 2E9NA_76A (CHEK1, PDB code: 2E9N, chain A)
Template Kinase: CHEK1
Template inhibitor: 2e9n

 18 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
AKT1AGC
CHEK1CAMK
MARK2CAMK
MAPKAPK23
CDK2CMGC
CDK4CMGC
GSK3BCMGC
MAPK1CMGC
MAPK10CMGC
MAPK14CMGC
AURKAOther
AURKBOther
FYNTK
SRCTK
HCKTK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
AKT1AGC
PRKCAAGC
PRKCBAGC
PRKCBAGC
SGK1AGC
CHEK1CAMK
MAPKAPK2CAMK
MARK2CAMK
CDK2CMGC
CDK4CMGC
GSK3BCMGC
MAPK1CMGC
MAPK10CMGC
MAPK14CMGC
AURKAOther
AURKBOther
FYNTK
HCKTK
SRCTK