Kinase profiling results of kinases in KIF 2XM8A_B4W (CHEK2, PDB code: 2XM8, chain A)
Template Kinase: CHEK2
Template inhibitor: PI_103

 12 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
CHEK1CAMK
PIM1CAMK
CHEK2CAMK
CDK2CMGC
CLK2CMGC
CLK3CMGC
DYRK1ACMGC
DYRK1BCMGC
SYKTK
TXKTK
IRAK4TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
CHEK1CAMK 
CHEK2CAMK 
PIM1CAMK 
CDC2CMGC 
CDC2CMGC 
CDK2CMGC 
CLK2CMGC 
CLK3CMGC 
DYRK1ACMGC 
DYRK1BCMGC 
SYKTK 
TXKTK 
IRAK4TKL