Kinase profiling results of kinases in KIF 2XM9A_LWH (CHEK2, PDB code: 2XM9, chain A)
Template Kinase: CHEK2
Template inhibitor: 4-(1h-Pyrazol-5-Yl)-2-{4-[(3s)-Pyrrolidin-3-Ylamino]quinazolin-2-Yl}phenol

 5 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
CHEK1CAMK
CHEK2CAMK
MAPK14CMGC
TXKTK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
CHEK1CAMK
CHEK2CAMK
CDC2CMGC
CDC2CMGC
MAPK14CMGC
TXKTK